DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and Rbak

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001038947.1	Gene:	Rbak / 57782	MGIID:	1927369	Length:	711	Species:	Mus musculus

Alignment Length:	504	Identity:	172/504 - (34%)
Similarity:	256/504 - (50%)	Gaps:	70/504 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SNSDFEELESEIKIENFCSYGK---DLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKT 90
            |..||      |::.:|.:|.:   :|:|                           |:||||.|:
Mouse   235 SGPDF------IQMSDFSTYPRSQMELKP---------------------------FECTQCGKS 266

  Fly    91 FTRKENLESHLRLHAEERPFECSHCSKSFGRR----THYKRHLLKHEKRPHKCSHCSKTFTQNSS 151
            |.:|.....|.|.|..|:|:.||.|.|||.::    .|.:.||   |::|:||:.|.|||.|...
Mouse   267 FCKKSKFIIHQRAHTGEKPYACSVCGKSFSQKGTLTVHRRSHL---EEKPYKCNECGKTFCQKLH 328

  Fly   152 LKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQ 216
            |.||...|:||:|::|::|..||.:|:||.:|.|.||.|||:.|..|.|:|...|.|.:|.|||.
Mouse   329 LTQHQRTHSGEKPYECSECGKSFCQKTHLTLHQRNHSGERPYPCNECGKSFSRKSALNDHQRTHT 393

  Fly   217 EARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPH 280
            ..:.:||:.|.||:..:|.|..|..|| .|:.::|::|.|.|.:...|.||.|.|..|.|::|..
Mouse   394 GEKLYKCNECGKSYYRKSTLITHQRTHTGEKPYQCSECGKFFSRVSYLTIHYRSHLEEKPYECTE 458

  Fly   281 CSETFARNSRLQLHLLEHA--------------------------GKEPLKCSQCSATFAMRSLY 319
            |.:||..||....|...||                          |::..:|::|..||...|.:
Mouse   459 CGKTFNLNSAFIRHWKVHAEERVQECGECGKPSPLQCAPDHTGDLGEKRYECNECGKTFLDSSAF 523

  Fly   320 RVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIG 384
            ..|..:...|:.|:|..|.|||...|....|.:.|:.|:||.|:.|.|.|...:.|..|...|.|
Mouse   524 HRHQSVPEGEKTYECNICGKSFSDSSCYTVHYRGHSEEKPFGCSECGKTFSHNSSLFRHQRVHTG 588

  Fly   385 EKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHC 449
            ||..:|..|.|.|...|.|.:|.:.|:|:..:||..|.|.::..|.|.:|.|:|:||.|::|:.|
Mouse   589 EKPYECYECGKFFSQKSYLTIHHRIHSGEKPYECSKCGKVFSRMSNLTVHYRSHSGEKPYECNEC 653

  Fly   450 SKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGT 498
            .|:|::.:....|.|||:|||||:|:.|..::..:|:...|.|....||
Mouse   654 GKVFSQKSYLTVHYRTHSGEKPYECNECGKKFHHRSAFNSHQRIHKRGT 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	158/434 (36%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	9/23 (39%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	13/24 (54%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	4/17 (24%)
Rbak	NP_001038947.1	KRAB	8..68	CDD:214630
		Required for interaction with RB1. /evidence=ECO:0000250	170..257		7/27 (26%)
		C2H2 Zn finger	260..280	CDD:275368	9/19 (47%)
		C2H2 Zn finger	288..308	CDD:275368	7/19 (37%)
		zf-C2H2	314..336	CDD:306579	10/21 (48%)
		C2H2 Zn finger	316..336	CDD:275368	9/19 (47%)
		COG5048	340..699	CDD:227381	125/358 (35%)
		C2H2 Zn finger	344..364	CDD:275368	9/19 (47%)
		C2H2 Zn finger	372..392	CDD:275368	8/19 (42%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		Interaction with AR. /evidence=ECO:0000250	414..711		95/289 (33%)
		C2H2 Zn finger	428..448	CDD:275368	8/19 (42%)
		C2H2 Zn finger	456..476	CDD:275368	7/19 (37%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
		C2H2 Zn finger	566..586	CDD:275368	6/19 (32%)
		C2H2 Zn finger	594..614	CDD:275368	7/19 (37%)
		C2H2 Zn finger	622..642	CDD:275368	7/19 (37%)
		C2H2 Zn finger	650..670	CDD:275368	6/19 (32%)
		C2H2 Zn finger	678..698	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900