DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF471

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_065864.2	Gene:	ZNF471 / 57573	HGNCID:	23226	Length:	626	Species:	Homo sapiens

Alignment Length:	492	Identity:	177/492 - (35%)
Similarity:	268/492 - (54%)	Gaps:	17/492 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EDTFEEEL----IF-----ISNSDFEELESEIKIENF--CSYGKDL-EPVKGVPSKLKTC--KSK 68
            ||.||:::    :|     |::.:....|:|.|...|  |.:.::: |.:....|..|:.  .|.
Human   128 EDLFEKQMGSHEMFSKKEIITHKETITKETEFKYTKFGKCIHLENIEESIYNHTSDKKSFSKNSM 192

  Fly    69 IAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE 133
            :.|.:.:......|||.:|.||||...:|..|.|:|..|:|:.|..|.|:|.:|.|..:|...|.
Human   193 VIKHKKVYVGKKLFKCNECDKTFTHSSSLTVHFRIHTGEKPYACEECGKAFKQRQHLAQHHRTHT 257

  Fly   134 -KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTH 197
             ::..:|..|.|.|.|:..|.||...||||:|:||.:|..:|.:.:||..|.|.|:.|:|:||..
Human   258 GEKLFECKECRKAFKQSEHLIQHQRIHTGEKPYKCKECRKAFRQPAHLAQHQRIHTGEKPYECKE 322

  Fly   198 CEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH--AERSFKCTQCPKTFLQN 260
            |.|||.:.|....|.|.|...||::|..|.|:|:..:...:|..::  .|:.|.|..|.|.|..:
Human   323 CGKAFSDGSSFARHQRCHTGKRPYECIECGKAFRYNTSFIRHWRSYHTGEKPFNCIDCGKAFSVH 387

  Fly   261 DSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRL 325
            ..|.:|.|:|.||.|:||..|.:||:..|...:|...|.|::|.:|..|...|:..:....|.|:
Human   388 IGLILHRRIHTGEKPYKCGVCGKTFSSGSSRTVHQRIHTGEKPYECDICGKDFSHHASLTQHQRV 452

  Fly   326 HTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKC 390
            |:.|:.|:|.||.|:|.:..|||.|.::||||:|::|..|.|.|:..:.|..|...|.|||..:|
Human   453 HSGEKPYECKECGKAFRQNVHLVSHLRIHTGEKPYECKECGKAFRISSQLATHQRIHTGEKPYEC 517

  Fly   391 SYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFAR 455
            ..|...||..|.|..|.:.|||:..:||..|.|:::.:|.|..|.|.||||.|:||:.|.|.|:.
Human   518 IECGNAFKQRSHLAQHQKTHTGEKPYECNECGKAFSQTSNLTQHQRIHTGEKPYKCTECGKAFSD 582

  Fly   456 SAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            |:...:|.|.|||::||:|..|...:.:|.||..|.|
Human   583 SSSCAQHQRLHTGQRPYQCFECGKAFRRKLSLICHQR 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	155/406 (38%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	13/24 (54%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF471	NP_065864.2	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	203..610	CDD:227381	156/406 (38%)
		C2H2 Zn finger	208..228	CDD:275368	9/19 (47%)
		zf-H2C2_2	220..245	CDD:290200	10/24 (42%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		zf-H2C2_2	248..273	CDD:290200	7/24 (29%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		zf-H2C2_2	276..301	CDD:290200	12/24 (50%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..328	CDD:290200	12/23 (52%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		zf-H2C2_2	332..357	CDD:290200	9/24 (38%)
		C2H2 Zn finger	348..366	CDD:275368	5/17 (29%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		zf-H2C2_2	393..414	CDD:290200	11/20 (55%)
		C2H2 Zn finger	405..425	CDD:275368	6/19 (32%)
		zf-H2C2_2	420..442	CDD:290200	7/21 (33%)
		C2H2 Zn finger	433..453	CDD:275368	5/19 (26%)
		zf-H2C2_2	445..470	CDD:290200	10/24 (42%)
		C2H2 Zn finger	461..481	CDD:275368	9/19 (47%)
		zf-H2C2_2	473..496	CDD:290200	12/22 (55%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		zf-H2C2_2	502..526	CDD:290200	9/23 (39%)
		C2H2 Zn finger	517..537	CDD:275368	7/19 (37%)
		zf-H2C2_2	529..554	CDD:290200	9/24 (38%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		zf-H2C2_2	557..581	CDD:290200	12/23 (52%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	601..621	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900