DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF304

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001277247.1	Gene:	ZNF304 / 57343	HGNCID:	13505	Length:	706	Species:	Homo sapiens

Alignment Length:	465	Identity:	173/465 - (37%)
Similarity:	236/465 - (50%)	Gaps:	27/465 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GKDLEPVKGV-----------PSKLKTCKSKIAKKRPLRK-QTD-----TFKCTQCQKTFTRKEN 96
            |.||....|:           |.:...|.........||: |.|     .|.|....|.|.....
Human   220 GMDLPDSSGLFQHQTTYNRVSPCRRTECMESFPHSSSLRQHQGDYDGQMLFSCGDEGKAFLDTFT 284

  Fly    97 LESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEK-----RPHKCSHCSKTFTQNSSLKQHL 156
            |......|||.|||.|..|...|..    |..|:.|.|     ..|.|..|.|.|.....||.|.
Human   285 LLDSQMTHAEVRPFRCLPCGNVFKE----KSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQ 345

  Fly   157 HEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPF 221
            ..|||:|.:.|::|..:|:||..|..|.|.|:.||.::|:.|.||:..:|||.:|.|.|...||:
Human   346 KFHTGKRHYTCSECGKAFSRKDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGERPY 410

  Fly   222 KCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETF 285
            ||:.|.|:|..:..|.:|...| .||.::|::|.|.|.|:..|..|.|:|.|..|::|..|.:.|
Human   411 KCNKCGKAFSRKDTLVQHQRFHTGERPYECSECGKFFSQSSHLIEHWRIHTGARPYECIECGKFF 475

  Fly   286 ARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEH 350
            :.||.|..|...|.|.....||:|...|..:.....|..:||..|.|:|:||.|:|.:|..||:|
Human   476 SHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSECGKAFSRKDTLVQH 540

  Fly   351 QQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQ 415
            |::||||||::|..|.|.|...::|.||...|.|.|..:|:.|.|.|..:|.|::|.:.|||...
Human   541 QKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQRVHTGARP 605

  Fly   416 FECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTR 480
            :.|..|.|:|.:||.|..|.:.|||..|::||.|.|.|:|::....|.|.|||||||.||.|...
Human   606 YVCSECGKAYISSSHLVQHKKVHTGARPYECSECGKFFSRNSGLILHQRVHTGEKPYVCSECGKA 670

  Fly   481 YTQKSSLGRH 490
            |::.|.|.||
Human   671 YSRSSHLVRH 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/415 (39%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	8/17 (47%)
ZNF304	NP_001277247.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		C2H2 Zn finger	169..186	CDD:275368
		C2H2 Zn finger	216..236	CDD:275368	4/15 (27%)
		C2H2 Zn finger	245..264	CDD:275368	4/18 (22%)
		C2H2 Zn finger	272..292	CDD:275368	4/19 (21%)
		C2H2 Zn finger	300..320	CDD:275368	7/23 (30%)
		COG5048	325..680	CDD:227381	143/354 (40%)
		C2H2 Zn finger	328..348	CDD:275368	7/19 (37%)
		zf-H2C2_2	340..365	CDD:290200	10/24 (42%)
		C2H2 Zn finger	356..376	CDD:275368	8/19 (42%)
		C2H2 Zn finger	384..404	CDD:275368	9/19 (47%)
		zf-H2C2_2	396..421	CDD:290200	12/24 (50%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		zf-H2C2_2	425..449	CDD:290200	9/23 (39%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	10/19 (53%)
		zf-H2C2_2	537..561	CDD:290200	14/23 (61%)
		C2H2 Zn finger	552..572	CDD:275368	7/19 (37%)
		zf-H2C2_2	564..589	CDD:290200	10/24 (42%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..628	CDD:275368	8/19 (42%)
		C2H2 Zn finger	636..656	CDD:275368	8/19 (42%)
		C2H2 Zn finger	664..684	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900