DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF286A

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001275571.1	Gene:	ZNF286A / 57335	HGNCID:	13501	Length:	564	Species:	Homo sapiens

Alignment Length:	490	Identity:	170/490 - (34%)
Similarity:	236/490 - (48%)	Gaps:	59/490 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KDEPPQEDTFEEEL-------IFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKI 69
            |.:|.|.|...|..       :.:|..:...||:          ||  ||:|   .:.|..||..
Human   104 KLDPAQRDVMLENYRNLVSLWLPVSKPESYNLEN----------GK--EPLK---LERKAPKSSY 153

  Fly    70 A--KKRPLRKQT----DTFKCTQCQ----KTFTRKENLESHLRLHAEERPFECSH-CSKSFGRRT 123
            :  :.||..|.:    |..|...|:    ...||....:|:|     |...||.: .....|.:.
Human   154 SDMETRPQSKDSTSVQDFSKAESCKVAIIDRLTRNSVYDSNL-----EAALECENWLENQQGNQE 213

  Fly   124 HYKRHLLKH-----EKRPHKCSHCSKTFTQNSSL-------KQHLHEHTGERPFKCTQCSTSFAR 176
            .:.|.:..|     |:..||.....|:|.|.|.|       |.....||.|:..|         :
Human   214 RHLREMFTHMNSLSEETDHKHDVYWKSFNQKSVLITEDRVPKGSYAFHTLEKSLK---------Q 269

  Fly   177 KSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLL 241
            ||:|....||:.|::|.:|..|.:.|..:|.|..|.|.|...:|:.|:.|.|||..|:.|.||..
Human   270 KSNLMKKQRTYKEKKPHKCNDCGELFTYHSVLIRHQRVHTGEKPYTCNECGKSFSHRANLTKHQR 334

  Fly   242 THAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKC 306
            ||....|:|::|.|||.::.||..|.|:|.||.|::|..|.:.|.|::.|..|.|.|.|.:|.:|
Human   335 THTRILFECSECKKTFTESSSLATHQRIHVGERPYECNECGKGFNRSTHLVQHQLIHTGVKPYEC 399

  Fly   307 SQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKC 371
            ::|...|...|....|.|.||.|:.|||.||.|:|...|.|.:||:|||||:|::|:.|.|.|..
Human   400 NECDKAFIHSSALIKHQRTHTGEKPYKCQECGKAFSHCSSLTKHQRVHTGEKPYECSECGKTFSQ 464

  Fly   372 RTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLR 436
            .|||..|...|.|||..:|:.|.|.|..||....|.:.|.||..::|..|.|::..||.|..|.|
Human   465 STHLVQHQRIHTGEKPYECNECGKTFSRSSNFAKHQRIHIGKKPYKCSECGKAFIHSSALIQHQR 529

  Fly   437 THTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKP 471
            |||||.||:|:.|.|.|..|:....|.|.||.|:|
Human   530 THTGEKPFRCNECGKSFKCSSSLIRHQRVHTEEQP 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	153/419 (37%)
		C2H2 Zn finger	84..104	CDD:275368	5/23 (22%)
		C2H2 Zn finger	112..132	CDD:275368	3/20 (15%)
		C2H2 Zn finger	139..159	CDD:275368	6/26 (23%)
		C2H2 Zn finger	167..187	CDD:275368	4/19 (21%)
		zf-H2C2_2	179..204	CDD:290200	8/24 (33%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368
ZNF286A	NP_001275571.1	KRAB	88..141	CDD:214630	10/48 (21%)
		KRAB	88..123	CDD:279668	5/18 (28%)
		COG5048	<265..400	CDD:227381	52/143 (36%)
		C2H2 Zn finger	288..308	CDD:275368	7/19 (37%)
		zf-H2C2_2	301..325	CDD:290200	10/23 (43%)
		C2H2 Zn finger	316..336	CDD:275368	9/19 (47%)
		C2H2 Zn finger	343..363	CDD:275368	9/19 (47%)
		zf-H2C2_2	355..380	CDD:290200	11/24 (46%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		zf-H2C2_2	383..406	CDD:290200	8/22 (36%)
		COG5048	<395..550	CDD:227381	68/154 (44%)
		zf-C2H2	397..419	CDD:278523	6/21 (29%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		zf-H2C2_2	411..436	CDD:290200	12/24 (50%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		zf-H2C2_2	439..464	CDD:290200	13/24 (54%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		zf-H2C2_2	467..492	CDD:290200	11/24 (46%)
		C2H2 Zn finger	483..503	CDD:275368	7/19 (37%)
		zf-H2C2_2	495..518	CDD:290200	7/22 (32%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		zf-H2C2_2	523..548	CDD:290200	14/24 (58%)
		C2H2 Zn finger	539..559	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900