DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF695

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_065127.5	Gene:	ZNF695 / 57116	HGNCID:	30954	Length:	515	Species:	Homo sapiens

Alignment Length:	498	Identity:	151/498 - (30%)
Similarity:	230/498 - (46%)	Gaps:	57/498 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EDTFEEELIFIS-------------------NSDFEELESEIKIENFCSYGKDLEPVKGVPSKLK 63
            ||:|..:.:|.|                   |.:.|:......:.::.:  :|:.|.:|    |:
Human    45 EDSFNMQFLFHSLAMSKPELIICLEARKEPWNVNTEKTARHSVLSSYLT--EDILPEQG----LQ 103

  Fly    64 TCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSH-----CSKSFGRRT 123
            ....|:..:|             .::....|..|.:...:..|.:..:.|:     ||.:    |
Human   104 VSFQKVMLRR-------------YERCCLEKLRLRNDWEIVGEWKGQKASYNGLDLCSAT----T 151

  Fly   124 HYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHS 188
            |.|.         .:|:.|.|.|::.::|.:....||||:||||.:|.........:....|.|.
Human   152 HSKN---------FQCNKCVKGFSKFANLNKCKISHTGEKPFKCKECGNVSCMSLIMTQQQRIHI 207

  Fly   189 EERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAE-RSFKCTQ 252
            .|.|::|..|.|||...|...:..|.|...:..||..|:..||..|.|......|.| ::::|.:
Human   208 GENPYQCKKCGKAFNECSCFTDCKRIHVGEKHCKCEECNNIFKSCSSLAVVEKNHTEKKTYRCEE 272

  Fly   253 CPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRS 317
            |.|.|.....|..|.::|.||.|:||..|.::|.....|..|...|:.::|.||.:|...|.:.|
Human   273 CGKAFNLCSVLTKHKKIHTGEKPYKCEECGKSFKLFPYLTQHKRIHSREKPYKCEECGKVFKLLS 337

  Fly   318 LYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDH 382
            ....|.|:||.|:.::|.||.|:|.:.|||.||:::||||:|:||..|.|.|...::|..|...|
Human   338 YLTQHRRIHTGEKTFRCEECGKAFNQSSHLTEHRRIHTGEKPYKCEECGKAFTWFSYLIQHKRIH 402

  Fly   383 IGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCS 447
            .|:|..||..|.|.|...|.|..|.:.|||:..::|..|.|::...|.|..|.|.||||.|:||.
Human   403 TGQKPYKCEECGKAFTWFSYLTQHKRIHTGEKPYKCDECGKAFNWFSYLTNHKRIHTGEKPYKCE 467

  Fly   448 HCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            .|.|.|.:|:...:|...||.||||||..|...:...:.|..|
Human   468 ECGKAFGQSSHLSKHKTIHTREKPYKCEECGKAFNHSAQLAVH 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	135/409 (33%)
		C2H2 Zn finger	84..104	CDD:275368	2/19 (11%)
		C2H2 Zn finger	112..132	CDD:275368	6/24 (25%)
		C2H2 Zn finger	139..159	CDD:275368	5/19 (26%)
		C2H2 Zn finger	167..187	CDD:275368	3/19 (16%)
		zf-H2C2_2	179..204	CDD:290200	9/24 (38%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	4/17 (24%)
ZNF695	NP_065127.5	KRAB	4..76	CDD:214630	5/30 (17%)
		COG5048	148..515	CDD:227381	133/376 (35%)
		C2H2 Zn finger	158..178	CDD:275368	5/19 (26%)
		C2H2 Zn finger	186..206	CDD:275368	3/19 (16%)
		C2H2 Zn finger	214..234	CDD:275368	7/19 (37%)
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	270..290	CDD:275368	6/19 (32%)
		C2H2 Zn finger	298..318	CDD:275368	5/19 (26%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		C2H2 Zn finger	354..374	CDD:275368	10/19 (53%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
		C2H2 Zn finger	466..486	CDD:275368	6/19 (32%)
		C2H2 Zn finger	494..514	CDD:275368	4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000