DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp109

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_030098682.1	Gene:	Zfp109 / 56869	MGIID:	1929099	Length:	682	Species:	Mus musculus

Alignment Length:	493	Identity:	169/493 - (34%)
Similarity:	251/493 - (50%)	Gaps:	31/493 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QRPVKDEP-----PQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGV-PSKLKTCK 66
            |.|||.:|     |..|    .:..:|:.|...|....|.::...:.|...||..| |..:.|
Mouse   206 QTPVKTKPRRLLAPGID----RMSCVSHQDNNTLHKGDKGQSNSDFDKLTFPVSPVTPHHVYT-- 264

  Fly    67 SKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLR-LHAEERPFECSHCSKSFGRRTHYKRHLL 130
                       :..::||::.|:.|..:..||.|.: |..::.|...::   ...|.:..::.:.
Mouse   265 -----------ERKSYKCSKAQEAFIDRPTLELHQQDLVGKKSPVRSTY---EVSRHSSIQKSVH 315

  Fly   131 KHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFEC 195
            ...|| :.|..|.|.|:|:|:|:.|...||||:|::|..|..:|.:.|.|..|.|.|:.|:|::|
Mouse   316 AGTKR-YWCHECGKAFSQSSALQTHRRVHTGEKPYRCDSCGKAFTQWSVLHAHQRIHTGEKPYKC 379

  Fly   196 THCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQ 259
            ..|.:.|:.:|:|..|.|.|...:|:||..|.|.|:.|  ...|...| .|:.:||.:|.|.|..
Mouse   380 GDCGRRFRFSSNLHIHQRVHTGEKPYKCHVCGKCFRFR--FYSHQRVHTGEKPYKCDECGKGFTS 442

  Fly   260 NDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVR 324
            ..::::|.|||.|..||.|..|.:.|:|:..|..|...|.|::..||..|...|:.||..:||..
Mouse   443 ASNVKVHQRVHTGVKPFCCNVCGKCFSRSFHLHTHQRVHTGEKLYKCDACGKAFSQRSSLQVHRL 507

  Fly   325 LHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPK 389
            :||.|:.|||.||.|.|...|....||:|||||:||.|..|.|||...::|::|...|.|||..|
Mouse   508 IHTGEKPYKCEECGKGFTSASSFQGHQRVHTGEKPFHCDVCGKDFSRSSYLQIHQRMHTGEKPYK 572

  Fly   390 CSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFA 454
            |..|.|.|...:.|.||.:.|||:..|:|..|.|.:...|.|..|...|..|.|:.|..|.|.|:
Mouse   573 CDSCGKAFSQRAHLQVHQRTHTGEKPFKCEECGKEFRQRSGLSSHQIVHKEEKPYTCWECGKGFS 637

  Fly   455 RSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            :.:..:.|.|.||||:||.|..|...::|:|.|.:|.|
Mouse   638 QPSLFERHRRVHTGERPYICGTCCKGFSQRSHLVKHQR 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	146/405 (36%)
		C2H2 Zn finger	84..104	CDD:275368	6/20 (30%)
		C2H2 Zn finger	112..132	CDD:275368	1/19 (5%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	9/24 (38%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
Zfp109	XP_030098682.1	KRAB	46..86	CDD:366587
		COG5048	<232..477	CDD:227381	78/263 (30%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		COG5048	<361..617	CDD:227381	101/257 (39%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	407..425	CDD:275368	6/19 (32%)
		C2H2 Zn finger	433..453	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	601..621	CDD:275368	6/19 (32%)
		C2H2 Zn finger	629..649	CDD:275368	6/19 (32%)
		C2H2 Zn finger	657..677	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900