DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZKSCAN7

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001275519.1	Gene:	ZKSCAN7 / 55888	HGNCID:	12955	Length:	754	Species:	Homo sapiens

Alignment Length:	444	Identity:	165/444 - (37%)
Similarity:	252/444 - (56%)	Gaps:	23/444 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKR 127
            |..:.:.:.:...|.:.|..:.|...|..:.|:..:.:                |..|.......
Human   320 KELEGQTSDEEGSRLENDFLEITDEDKKKSTKDRYDKY----------------KEVGEHPPLSS 368

  Fly   128 HLLKHE-----KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTH 187
            ..::||     ::.::|..|.|.|.::|.|..|...||||:|::|.:|..:|.:.|.|.||||||
Human   369 SPVEHEGVLKGQKSYRCDECGKAFNRSSHLIGHQRIHTGEKPYECNECGKTFRQTSQLIVHLRTH 433

  Fly   188 SEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCT 251
            :.|:|:||:.|.||::::|||.:|.|.|...:|:||:.|:|:|...|.|..|..|| .|:.::|.
Human   434 TGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPYKCNECAKAFTQSSRLTDHQRTHTGEKPYECN 498

  Fly   252 QCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMR 316
            :|.:.|:::.||..|..:|.|:.|:||..|...|..|..|..|...|.|::|.:||:|...|:..
Human   499 ECGEAFIRSKSLARHQVLHTGKKPYKCNECGRAFCSNRNLIDHQRIHTGEKPYECSECGKAFSRS 563

  Fly   317 SLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLD 381
            .....|..|||.|:.|||:||.|:|.:.|.|:||:::||||:||:|:.|.|.|.....|..|...
Human   564 KCLIRHQSLHTGEKPYKCSECGKAFNQNSQLIEHERIHTGEKPFECSECGKAFGLSKCLIRHQRL 628

  Fly   382 HIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKC 446
            |.|||..||:.|.|.|..:|.|::|.:.|||:..:||..|.|.::.||:|.:|.||||||.|:||
Human   629 HTGEKPYKCNECGKSFNQNSHLIIHQRIHTGEKPYECNECGKVFSYSSSLMVHQRTHTGEKPYKC 693

  Fly   447 SHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTKS 500
            :.|.|.|:.|::...|.|.|||||||:||.|...::|:|:...| :||..|.||
Human   694 NDCGKAFSDSSQLIVHQRVHTGEKPYECSECGKAFSQRSTFNHH-QRTHTGEKS 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	155/409 (38%)
		C2H2 Zn finger	84..104	CDD:275368	3/19 (16%)
		C2H2 Zn finger	112..132	CDD:275368	2/19 (11%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	14/24 (58%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZKSCAN7	NP_001275519.1	SCAN	51..161	CDD:128708
		SCAN	51..138	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..215
		KRAB_A-box	231..270	CDD:143639
		COG5048	380..738	CDD:227381	150/358 (42%)
		zf-C2H2	383..405	CDD:278523	7/21 (33%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	401..422	CDD:290200	9/20 (45%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..450	CDD:290200	14/23 (61%)
		C2H2 Zn finger	441..461	CDD:275368	9/19 (47%)
		zf-H2C2_2	453..478	CDD:290200	11/24 (46%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		zf-H2C2_2	482..506	CDD:290200	8/23 (35%)
		C2H2 Zn finger	497..517	CDD:275368	6/19 (32%)
		zf-H2C2_2	509..532	CDD:290200	9/22 (41%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		zf-H2C2_2	537..562	CDD:290200	9/24 (38%)
		C2H2 Zn finger	553..573	CDD:275368	5/19 (26%)
		zf-H2C2_2	566..590	CDD:290200	12/23 (52%)
		C2H2 Zn finger	581..601	CDD:275368	9/19 (47%)
		zf-H2C2_2	594..616	CDD:290200	12/21 (57%)
		C2H2 Zn finger	609..629	CDD:275368	6/19 (32%)
		zf-H2C2_2	622..646	CDD:290200	11/23 (48%)
		C2H2 Zn finger	637..657	CDD:275368	7/19 (37%)
		zf-H2C2_2	649..674	CDD:290200	9/24 (38%)
		C2H2 Zn finger	665..685	CDD:275368	8/19 (42%)
		zf-H2C2_2	677..701	CDD:290200	13/23 (57%)
		C2H2 Zn finger	693..713	CDD:275368	7/19 (37%)
		zf-H2C2_2	706..730	CDD:290200	12/23 (52%)
		C2H2 Zn finger	721..741	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..754		6/13 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000