DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF701

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001166126.1	Gene:	ZNF701 / 55762	HGNCID:	25597	Length:	531	Species:	Homo sapiens

Alignment Length:	535	Identity:	166/535 - (31%)
Similarity:	245/535 - (45%)	Gaps:	92/535 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PVKDEPPQEDTFEEELIFISNSD----FEELESEIKIENFCSYGKDL-EPVKGVPSKLKTCKSKI 69
            |...:||...:....:..:|:..    ||.|.|           ||| ...|....|.|..:|.:
Human    14 PTSGDPPASASQSAGITGVSHRTQPPCFEGLTS-----------KDLVREEKTRKRKRKAKESGM 67

  Fly    70 AKKRPLRKQTDT--------FKCTQ-CQKTFTRKENLESHLRLHAEERPFEC------------- 112
            |..:.|....|.        :||.. .|:|..|...||::..|.:.:...:|
Human    68 ALLQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDTSSKCMMKMFSSTGQGNT 132

  Fly   113 ------------SH-----CSKSFGRRTH-YKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEH 159
                        ||     |.:...:..| :.....::|...|: :..:||....||.::|...|
Human   133 EVVHTGTLQIHASHHIGDTCFQEIEKDIHDFVFQWQENETNGHE-ALMTKTKKLMSSTERHDQRH 196

  Fly   160 TGERPFKCTQCSTSFARKSHL-QVHLRTHSE-------------------ERPFEC---THCEKA 201
            .|.:|.| .:..:||  .||| :||: .|.|                   .:...|   |.....
Human   197 AGNKPIK-NELGSSF--HSHLPEVHI-FHPEGKIGNQVEKAINDAFSVSASQRISCRPKTRISNK 257

  Fly   202 FKNNSHLQEHLRT-----HQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQN 260
            ::|| .||..|.|     |...:.|:.:...|:|...|:|:||.:.| .::.:||..|.|.|.|.
Human   258 YRNN-FLQSSLLTQKREVHTREKSFQRNESGKAFNGSSLLKKHQIIHLGDKQYKCDVCGKDFHQK 321

  Fly   261 DSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRL 325
            ..|..| |.|.||:|:.|..|.:||:.||.|.:|...|.|::|.||::|...|..:|....|.|:
Human   322 RYLACH-RCHTGENPYTCNECGKTFSHNSALLVHKAIHTGEKPYKCNECGKVFNQQSNLARHHRV 385

  Fly   326 HTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKC 390
            ||.|:.|||.||.|.|.:||||..|:::||||:|:||..|.|.|:..:||..|.:.|.|||..||
Human   386 HTGEKPYKCEECDKVFSRKSHLERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHTVIHTGEKPYKC 450

  Fly   391 SYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFAR 455
            :.|.|.|..:|.|::|...|||:.:::|..|.|.:...|.|..|.|.||||.|:||:.|.|:|.|
Human   451 NECGKTFVQNSSLVMHKVIHTGEKRYKCNECGKVFNHKSNLACHRRLHTGEKPYKCNECGKVFNR 515

  Fly   456 SAEHQEHLRTHTGEK 470
            .:..:.|.|.|||:|
Human   516 KSNLERHHRLHTGKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	150/466 (32%)
		C2H2 Zn finger	84..104	CDD:275368	6/20 (30%)
		C2H2 Zn finger	112..132	CDD:275368	5/50 (10%)
		C2H2 Zn finger	139..159	CDD:275368	5/19 (26%)
		C2H2 Zn finger	167..187	CDD:275368	7/20 (35%)
		zf-H2C2_2	179..204	CDD:290200	8/47 (17%)
		C2H2 Zn finger	195..215	CDD:275368	8/27 (30%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368
ZNF701	NP_001166126.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		4/27 (15%)
		KRAB	74..>114	CDD:214630	9/39 (23%)
		KRAB	74..113	CDD:279668	9/38 (24%)
		C2H2 Zn finger	283..303	CDD:275368	6/19 (32%)
		zf-H2C2_2	296..320	CDD:290200	9/23 (39%)
		C2H2 Zn finger	311..330	CDD:275368	8/19 (42%)
		C2H2 Zn finger	338..358	CDD:275368	8/19 (42%)
		zf-H2C2_2	350..375	CDD:290200	9/24 (38%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		zf-H2C2_2	378..403	CDD:290200	12/24 (50%)
		COG5048	<390..527	CDD:227381	60/136 (44%)
		C2H2 Zn finger	394..414	CDD:275368	10/19 (53%)
		zf-H2C2_2	406..431	CDD:290200	13/24 (54%)
		C2H2 Zn finger	422..442	CDD:275368	7/19 (37%)
		zf-H2C2_2	434..459	CDD:290200	12/24 (50%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		zf-H2C2_2	462..487	CDD:290200	8/24 (33%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..515	CDD:290200	13/24 (54%)
		C2H2 Zn finger	506..526	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900