DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZSCAN2

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_024305746.1	Gene:	ZSCAN2 / 54993	HGNCID:	20994	Length:	645	Species:	Homo sapiens

Alignment Length:	476	Identity:	175/476 - (36%)
Similarity:	263/476 - (55%)	Gaps:	16/476 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLANVDQRPVKDEPPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVP---SKLK 63
            |:...:.|.:..|.|:.::.:..   ...||||. ::.|:.....|.|:|...|....   .:|.
Human   181 DMFENESRKIFSEMPEGESAQHS---DGESDFER-DAGIQRLQGHSPGEDHGEVVSQDREVGQLI 241

  Fly    64 TCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRH 128
            ..:.....::|       ::|.||.|||:||.:|.:|.|.|..|:.::|..|.|||...:::.||
Human   242 GLQGTYLGEKP-------YECPQCGKTFSRKSHLITHERTHTGEKYYKCDECGKSFSDGSNFSRH 299

  Fly   129 LLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERP 192
            ...|. ::|:||..|.|:|:::::|..|...||||:||:|.:|..||:|..:|..|.|||:.|:|
Human   300 QTTHTGEKPYKCRDCGKSFSRSANLITHQRIHTGEKPFQCAECGKSFSRSPNLIAHQRTHTGEKP 364

  Fly   193 FECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKT 256
            :.|..|.|:|.|.|.|..|...|...:|::|..|.:||...|.|.:|...| .|:.:|||.|.:.
Human   365 YSCPECGKSFGNRSSLNTHQGIHTGEKPYECKECGESFSYNSNLIRHQRIHTGEKPYKCTDCGQR 429

  Fly   257 FLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRV 321
            |.|:.:|..|.|.|.||.|::|..|.::|:|:|.|..|...|..::|.||..|..:|:..|....
Human   430 FSQSSALITHRRTHTGEKPYQCSECGKSFSRSSNLATHRRTHMVEKPYKCGVCGKSFSQSSSLIA 494

  Fly   322 HVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEK 386
            |..:||.|:.|:|..|.:||...|:|::||::||||:|:||:.|.|.|..|:.|.||...|.|||
Human   495 HQGMHTGEKPYECLTCGESFSWSSNLLKHQRIHTGEKPYKCSECGKCFSQRSQLVVHQRTHTGEK 559

  Fly   387 VPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSK 451
            ..||..|.|.|...|.|::|.:.|.|...:.||.|.|.::.:|.|.:|.|.||||.|:||..|.|
Human   560 PYKCLMCGKSFSRGSILVMHQRAHLGDKPYRCPECGKGFSWNSVLIIHQRIHTGEKPYKCPECGK 624

  Fly   452 LFARSAEHQEHLRTHTGEKPY 472
            .|:.|:....|.|||..||.|
Human   625 GFSNSSNFITHQRTHMKEKLY 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/401 (40%)
		C2H2 Zn finger	84..104	CDD:275368	11/19 (58%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368
ZSCAN2	XP_024305746.1	SCAN	70..157	CDD:322011
		COG5048	251..631	CDD:227381	154/386 (40%)
		C2H2 Zn finger	255..275	CDD:275368	11/19 (58%)
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		C2H2 Zn finger	339..359	CDD:275368	8/19 (42%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	479..499	CDD:275368	5/19 (26%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		C2H2 Zn finger	535..555	CDD:275368	8/19 (42%)
		C2H2 Zn finger	563..583	CDD:275368	7/19 (37%)
		C2H2 Zn finger	591..611	CDD:275368	8/19 (42%)
		C2H2 Zn finger	619..639	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000