Protein Alignment CG5245 and ZNF727

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001152994.1
• Gene: ZNF727 / 442319
• HGNCID: 22785
• Length: 499
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 158/495 - (31%)
• Similarity: 223/495 - (45%)
• Gaps: 63/495 - (12%)

  Fly    20 TFEEELIFISNSDFEELES-------EIKIENF--------CSYGKDL--------EPVKGVPSK 61
            ||.:..:..|..::|.|:|       ::.:||:        ..:..||        ||
Human     5 TFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSLGLAIFKPDLITYLEQRKEP------- 62

  Fly    62 LKTCKSKIAKKRPL------------RKQTDTFKCTQCQKTFTRKE---NLESHLRLHAE-ERPF 110
            ....:.|...|.|.            ....|:|     ||...||.   :|.: |||..: :|..
Human    63 WNARRQKTVAKHPAGSLHFTAEILLEHDINDSF-----QKVILRKSGSCDLNT-LRLKKDYQRVG 121

  Fly   111 ECSHCSKSFGRRTHYKR-HLLKHEKRPHKCSH--CSKTFTQNSSLKQHLHEHTGERPFKCTQCST 172
            .|.      |:::.|.. |......|...|.:  |.|.|...|...:|....:.|:.:||.:|..
Human   122 NCK------GQKSSYNGIHQCLSATRSKTCQYNKCGKAFGLCSIFTEHKKIFSREKCYKCEECGK 180

  Fly   173 SFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQ 237
            . .|.|...:..|.|:.:|.::|..|.||.|..|:|.||.|.|...:|:||..|.|:|...|.|.
Human   181 D-CRLSDFTIQKRIHTADRSYKCEECGKACKKFSNLTEHNRVHTGKKPYKCEECGKTFTCSSALT 244

  Fly   238 KHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGK 301
            ||...| .:|.:||.:|.|.|.....|..|.|:|.||.|:||..|.:.|...|.|..|...|.|:
Human   245 KHKRNHTGDRPYKCEECHKAFRCCSDLTKHKRIHTGEKPYKCKECHKAFRCCSDLTKHKRIHTGE 309

  Fly   302 EPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCF 366
            :|.||::|...|...|....|.|:||.|:.|.|.||.|:|...|.|:.|:::|...||:||..|.
Human   310 KPYKCNECGKAFMWISALSQHNRIHTGEKPYICEECGKAFTYSSTLISHKRIHMELRPYKCEECG 374

  Fly   367 KDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTL 431
            |.||..:.|..|...|.|||..||..|.|.|..||.|:.|.:.|.....::|..|.|::.....|
Human   375 KTFKWFSDLTNHKRIHTGEKPYKCEECGKSFTCSSNLIKHKRIHMEVRPYKCEECGKTFKWFPDL 439

  Fly   432 HMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKP 471
            ..|.|.||||.|:||..|.|.|..|:...:|.|:|||::|
Human   440 TNHKRIHTGEKPYKCEECGKTFTCSSSLIKHKRSHTGDRP 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	144/418 (34%)
		C2H2 Zn finger	84..104	CDD:275368	7/22 (32%)
		C2H2 Zn finger	112..132	CDD:275368	4/20 (20%)
		C2H2 Zn finger	139..159	CDD:275368	6/21 (29%)
		C2H2 Zn finger	167..187	CDD:275368	5/19 (26%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368
ZNF727	NP_001152994.1	KRAB	4..64	CDD:214630	12/65 (18%)
		C2H2 Zn finger	148..167	CDD:275370	5/18 (28%)
		C2H2 Zn finger	175..194	CDD:275368	5/19 (26%)
		C2H2 Zn finger	202..222	CDD:275368	10/19 (53%)
		zf-H2C2_2	214..239	CDD:463886	11/24 (46%)
		C2H2 Zn finger	230..250	CDD:275368	8/19 (42%)
		zf-H2C2_2	242..267	CDD:463886	10/24 (42%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		zf-H2C2_2	270..295	CDD:463886	11/24 (46%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		COG5048	<296..465	CDD:227381	66/168 (39%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	8/19 (42%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		SFP1	<392..477	CDD:227516	34/84 (40%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	7/19 (37%)