DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF716

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001152751.1	Gene:	ZNF716 / 441234	HGNCID:	32458	Length:	495	Species:	Homo sapiens

Alignment Length:	437	Identity:	144/437 - (32%)
Similarity:	215/437 - (49%)	Gaps:	42/437 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CS-YGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKE------NLESHLRL 103
            || :.:||:..:|:...|:    |:..:|..:...:..:..:|.|:....|      |..:....
Human    90 CSHFTQDLQSEQGIKDSLQ----KVILRRYGKCGQEDLQVKKCCKSVGECEVHKGGYNYVNQCLS 150

  Fly   104 HAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPH-KCSHCSKTFTQNSSLKQHLHEHTGERPFKC 167
            ..:.:.|:...|.|.||:.::..||..:|..:.| ||.:..|:|...|.|.||...||.|:.:||
Human   151 ATQNKTFQTHKCVKVFGKFSNSNRHKTRHTGKKHFKCKNDGKSFCMLSRLNQHQIIHTREKSYKC 215

  Fly   168 TQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKL 232
            .:|..||...|.|..|.|.|:.|:|:.|..|.|||..::.|.:|.|.|...:|:.|....|.|.
Human   216 EECGKSFNCSSTLTRHKRIHTGEKPYRCEECGKAFSWSASLTKHKRIHTGEKPYTCEERGKVFS- 279

  Fly   233 RSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLL 296
            ||.|..:...| .|:.:.|.:|.|.|.::.:|..|.|:|.||.|:||..|.:.|:.:|.|:.|.:
Human   280 RSTLTNYKRIHTGEKPYTCEECGKAFSRSSTLTNHKRIHTGERPYKCEECGKAFSLSSTLKKHKI 344

  Fly   297 EHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFK 361
            .|.|::...|.:|...|...|....|.|:||.|:.|.|.||.|:|...|....|::.||||:|:|
Human   345 VHTGEKLYTCEECGKAFTFSSTLNTHKRIHTGEKPYTCEECGKAFSLPSTFTYHKRTHTGEKPYK 409

  Fly   362 CTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYT 426
            |..|.|.|.|.:.|:.|.:.|.|||:                            ::|..|.|::|
Human   410 CEECGKAFNCSSTLKKHKIIHTGEKL----------------------------YKCKECGKAFT 446

  Fly   427 TSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYK 473
            .||||:.|.|.||||.|:||..|.:.|...:....|...||||||||
Human   447 FSSTLNTHKRIHTGEKPYKCEECDQTFKWHSSLANHKNMHTGEKPYK 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	136/408 (33%)
		C2H2 Zn finger	84..104	CDD:275368	4/25 (16%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	0/19 (0%)
		C2H2 Zn finger	418..438	CDD:275368	10/19 (53%)
		C2H2 Zn finger	446..466	CDD:275368	4/19 (21%)
		C2H2 Zn finger	474..492	CDD:275368	144/437 (33%)
ZNF716	NP_001152751.1	KRAB	16..76	CDD:214630
		KRAB	16..55	CDD:279668
		C2H2 Zn finger	160..179	CDD:275368	6/18 (33%)
		C2H2 Zn finger	187..207	CDD:275368	7/19 (37%)
		COG5048	211..>494	CDD:227381	112/312 (36%)
		C2H2 Zn finger	215..235	CDD:275368	8/19 (42%)
		zf-H2C2_2	228..251	CDD:290200	10/22 (45%)
		C2H2 Zn finger	243..263	CDD:275368	8/19 (42%)
		zf-H2C2_2	283..307	CDD:290200	7/23 (30%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		zf-H2C2_2	311..334	CDD:290200	10/22 (45%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		CpXC	353..>398	CDD:291051	16/44 (36%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	398..419	CDD:290200	11/20 (55%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		zf-H2C2_2	423..446	CDD:290200	9/50 (18%)
		C2H2 Zn finger	438..458	CDD:275368	10/19 (53%)
		zf-H2C2_2	451..474	CDD:290200	11/22 (50%)
		C2H2 Zn finger	466..486	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900