DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF724

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001342333.1	Gene:	ZNF724 / 440519	HGNCID:	32460	Length:	619	Species:	Homo sapiens

Alignment Length:	493	Identity:	172/493 - (34%)
Similarity:	248/493 - (50%)	Gaps:	28/493 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTC------KSKIAKKRPL 75
            |.|.:.::....|||:..:.|..                   |.|.|.|      .|.:.:.:.:
Human   146 QCDKYVKDFHKFSNSNRHKTEKN-------------------PFKCKECGKSFCVLSHLTQHKRI 191

  Fly    76 RKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKC 139
            ....:::|..:|.|.|.....|..|.|:|..::.::|..|..:|.:.:|...|.:.|. ::.:|.
Human   192 HTTVNSYKLEECGKAFNVSSTLSQHKRIHTGQKHYKCEECGIAFNKSSHLNTHKIIHTGEKSYKR 256

  Fly   140 SHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKN 204
            ..|.|.|..:|.|..|...||||..:||.:|..:|.:.|.|..|...|:.|:|:.|.||.:||..
Human   257 EECGKAFNISSHLTTHKIIHTGENAYKCKECGKAFNQSSTLTRHKIIHAGEKPYICEHCGRAFNQ 321

  Fly   205 NSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLR 268
            :|:|.:|.|.|...:|:||..|.|:|.:.|.|.:|...| .|:.:||.:|.|.|..:.:|..|.|
Human   322 SSNLTKHKRIHTGDKPYKCEECGKAFNVSSTLTQHKRIHTGEKPYKCEECGKAFNVSSTLTQHKR 386

  Fly   269 VHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYK 333
            :|.||.|:||..|.:.|..:|.|..|...|.|::|.||.:|...|...|....|..:||.|:.||
Human   387 IHTGEKPYKCEECGKAFNTSSHLTTHKRIHTGEKPYKCEECGKAFNQFSQLTTHKIIHTGEKPYK 451

  Fly   334 CAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFK 398
            |.||.|:|.:.|:|.||:.:||||:|:||..|.|.|...:||..|...|.|||..||..|.|.|.
Human   452 CKECGKAFKRSSNLTEHRIIHTGEKPYKCEECGKAFNLSSHLTTHKKIHTGEKPYKCKECGKAFN 516

  Fly   399 LSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHL 463
            .||.|..|...|.|:..::|..|.|::...|.|..|...||||.|:||..|.|.|..|:...:|.
Human   517 QSSTLARHKIIHAGEKPYKCEECGKAFYQYSNLTQHKIIHTGEKPYKCEECGKAFNWSSTLTKHK 581

  Fly   464 RTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTKSD 501
            ..|||||||||..|...:.|.|:|..| ::.....|||
Human   582 VIHTGEKPYKCKECGKAFNQCSNLTTH-KKIHAVEKSD 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	153/405 (38%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF724	NP_001342333.1	KRAB	4..64	CDD:214630
		COG5048	143..526	CDD:227381	135/398 (34%)
		C2H2 Zn finger	172..192	CDD:275368	3/19 (16%)
		C2H2 Zn finger	201..220	CDD:275368	6/18 (33%)
		C2H2 Zn finger	228..248	CDD:275368	5/19 (26%)
		C2H2 Zn finger	257..276	CDD:275368	6/18 (33%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	452..472	CDD:275368	9/19 (47%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		SFP1	<530..610	CDD:227516	33/80 (41%)
		C2H2 Zn finger	536..556	CDD:275368	6/19 (32%)
		zf-H2C2_2	548..572	CDD:316026	11/23 (48%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		C2H2 Zn finger	592..612	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900