DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp975

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001008427.1	Gene:	Zfp975 / 434179	MGIID:	3648690	Length:	525	Species:	Mus musculus

Alignment Length:	413	Identity:	158/413 - (38%)
Similarity:	242/413 - (58%)	Gaps:	10/413 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SKLKTCKSKIAKKRPLRKQTDT----FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFG 120
            ||:..|:|.:    .:.::|.|    :||.:|.|.|.:.:.|.:|.|.|..|:.:||:.|.|:|.
Mouse   109 SKVLACQSTL----QINERTGTGEKPYKCNECDKAFLKLKYLRAHERTHTGEKLYECNQCGKAFV 169

  Fly   121 RRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHL 184
            ..::.:.|...|. ::|::|:.|.|.|...|.|:.|...|||.||:.|.||:.::.|:|.|:.|.
Mouse   170 HPSYLRMHERTHTGEKPYQCNQCGKAFALRSHLQSHKVVHTGVRPYICNQCNKAYPRQSCLRKHE 234

  Fly   185 RTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSF 248
            |||:.|:|:.|..|.||:.:.|:|:.|.|||..|:|:.|:.|.|:|..:|..|.|..|| .|:.:
Mouse   235 RTHTGEKPYICNLCNKAYSHQSNLRIHERTHNGAKPYICNLCDKAFSQQSCFQIHEKTHTGEKPY 299

  Fly   249 KCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATF 313
            ||.||.|.|.|...|:.|.|.|..|..:||..|.:.||:.:.|::|...|:|::|.||::|...|
Mouse   300 KCNQCDKGFAQLRYLRAHERTHTQEKTYKCNQCGKAFAQLTYLRVHERRHSGEKPYKCNECDKAF 364

  Fly   314 AMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVH 378
            ......|:|.|.||.|:.|||.:|.|:|...|:|..|::.||||:|::|..|.|.|....:||:|
Mouse   365 LQLKYLRLHERRHTGEKPYKCNQCGKAFLHPSYLRMHERTHTGEKPYQCNECNKAFLQLRYLRLH 429

  Fly   379 MLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELP 443
            ...|.|||..:|:.|.|.|...:.|.:|.:.|:|:..:||..|.|::...|.|.||.||||||.|
Mouse   430 ERRHSGEKPYECNQCGKAFLRPNNLRMHERRHSGEKPYECNQCGKAFLHPSYLRMHERTHTGEKP 494

  Fly   444 FKCSHCSKLFARSAEHQEHLRTH 466
            ::||.|.|.|.:....::|.:||
Mouse   495 YECSQCGKAFLQPHYLRKHEKTH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	154/399 (39%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368
Zfp975	NP_001008427.1	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	98..514	CDD:227381	155/408 (38%)
		C2H2 Zn finger	109..125	CDD:275368	4/19 (21%)
		C2H2 Zn finger	133..153	CDD:275368	7/19 (37%)
		zf-H2C2_2	145..170	CDD:290200	10/24 (42%)
		C2H2 Zn finger	161..181	CDD:275368	5/19 (26%)
		zf-H2C2_2	173..197	CDD:290200	6/23 (26%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..310	CDD:290200	11/23 (48%)
		C2H2 Zn finger	301..321	CDD:275368	9/19 (47%)
		zf-H2C2_2	313..338	CDD:290200	9/24 (38%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		zf-H2C2_2	341..366	CDD:290200	9/24 (38%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	369..394	CDD:290200	12/24 (50%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	11/24 (46%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	425..450	CDD:290200	11/24 (46%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		zf-H2C2_2	453..478	CDD:290200	8/24 (33%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		zf-H2C2_2	481..506	CDD:290200	15/24 (63%)
		C2H2 Zn finger	497..517	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900