DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and Zfp873

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_036011778.1	Gene:	Zfp873 / 408062	MGIID:	3040689	Length:	673	Species:	Mus musculus

Alignment Length:	525	Identity:	198/525 - (37%)
Similarity:	282/525 - (53%)	Gaps:	57/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LANVDQRPVKDEPPQEDTFEEELIFISNS---DFEELESEIKIENFCSYGKDLEPVKGVPSKLKT 64
            :.|...:|.::    ||..:::..|..||   .:|.:.:|.|......|.|.......:|..
Mouse    66 ICNCGYKPCEN----EDHGKKQCSFACNSFLQMYERIYNEEKAYECNQYSKAFVNFHSLPQH--- 123

  Fly    65 CKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHY---- 125
                 ||..| |:|  .::|..|.|.:....: :.|.|.|..|:|:|||.|.|:|....|.
Mouse   124 -----AKNHP-REQ--PYECNHCGKAYVSPSS-QIHKRSHVGEKPYECSKCGKAFENDNHLQNRE 179

  Fly   126 KRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEE 190
            |.|.|   ::..:||.|.|.|...|.|..|...||||:|::||||..:|..:|:|::|...|:.|
Mouse   180 KHHTL---EKLFECSQCGKAFASRSYLPIHRRIHTGEKPYECTQCGKAFTSRSYLKIHKSVHTGE 241

  Fly   191 RPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCP 254
            :|:||..|.|||.|...|::|.:.|...:|::||||||:|...|.||.|..|| .|:.:.||:|.
Mouse   242 KPYECNQCSKAFANFYSLRQHEKYHTREKPYECSHCSKAFPSPSSLQVHERTHTGEKPYDCTECG 306

  Fly   255 KTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFA-MRSL 318
            |.|:.:.|||||.|||.||.|::|..|.:.|...|.|::|...|.|::|.:|||||..|| .|||
Mouse   307 KAFISHSSLQIHKRVHTGEKPYECTLCGKAFVNRSYLEVHKRIHTGEKPYECSQCSKAFANFRSL 371

  Fly   319 YRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKC------------------TH- 364
             |.|.:.||||:.|:|::|||:|....||..||:.||||:|:.|                  ||
Mouse   372 -RQHEKNHTREKPYECSQCSKAFVSPCHLQIHQRTHTGEKPYDCSDCGKAFTRLSNLQVHKRTHT 435

  Fly   365 ---------CFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPH 420
                     |.|.|.|.::|::|...|.|||...|:.|.|.|...:.|..|.:.|||:..:.|..
Mouse   436 GQKPYCCSQCGKAFPCFSNLQIHERTHTGEKPYACNQCGKAFASRASLQYHEKHHTGEKPYGCNQ 500

  Fly   421 CSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKS 485
            |.|::.:.|.|.:|.||||||.|::||.|.|.|||.:..|.|.|:|||||||.|:.|...:..::
Mouse   501 CGKAFVSPSHLQIHQRTHTGEKPYECSQCGKAFARRSNLQIHERSHTGEKPYDCNQCGKAFASRA 565

  Fly   486 SLGRH 490
            ||..|
Mouse   566 SLQYH 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	179/437 (41%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	9/23 (39%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	11/19 (58%)
		C2H2 Zn finger	250..270	CDD:275368	11/19 (58%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	12/20 (60%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	9/47 (19%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	10/19 (53%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp873	XP_036011778.1	KRAB	4..44	CDD:396083
		C2H2 Zn finger	107..127	CDD:275368	5/27 (19%)
		C2H2 Zn finger	135..154	CDD:275368	5/19 (26%)
		COG5048	158..573	CDD:227381	173/417 (41%)
		C2H2 Zn finger	162..182	CDD:275368	7/19 (37%)
		C2H2 Zn finger	190..210	CDD:275368	8/19 (42%)
		C2H2 Zn finger	218..238	CDD:275368	8/19 (42%)
		C2H2 Zn finger	246..266	CDD:275368	8/19 (42%)
		C2H2 Zn finger	274..294	CDD:275368	11/19 (58%)
		C2H2 Zn finger	302..322	CDD:275368	11/19 (58%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	358..378	CDD:275368	12/20 (60%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		C2H2 Zn finger	414..434	CDD:275368	1/19 (5%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		C2H2 Zn finger	470..490	CDD:275368	6/19 (32%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		C2H2 Zn finger	526..546	CDD:275368	10/19 (53%)
		C2H2 Zn finger	554..574	CDD:275368	5/17 (29%)
		C2H2 Zn finger	582..602	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900