Protein Alignment CG5245 and ZNF805

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001018857.2
• Gene: ZNF805 / 390980
• HGNCID: 23272
• Length: 627
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 159/459 - (34%)
• Similarity: 237/459 - (51%)
• Gaps: 47/459 - (10%)

  Fly    42 IENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRP-LRKQTDTFKCTQCQKTFTRKENLESHLRLHA 105
            |::..|.|.|:.          .|.|..:.|.| ::::.:.|||.:|:|.|.:|..|..|.|:|:
Human   172 IQDRVSLGDDVH----------DCDSHGSGKNPVIQEEENIFKCNECEKVFNKKRLLARHERIHS 226

  Fly   106 EERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQC 170
            ..:|:||:.|.|:|.:.|:                           |.||...||||:|:||.:|
Human   227 GVKPYECTECGKTFSKSTY---------------------------LLQHHMVHTGEKPYKCMEC 264

  Fly   171 STSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSI 235
            ..:|.|||||..|.|.||.|:|::|:.|.|||.:.|....|.|:|...:||.|..|.|:|:.|..
Human   265 GKAFNRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPG 329

  Fly   236 LQKHLLTHA-ERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHA 299
            ..:|.:.|: |..::|.:|.|.|.....|..|.:.|.||.|::|..|.:.|..::.|..|.:.|.
Human   330 FIRHYIIHSGENPYECFECGKVFKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHT 394

  Fly   300 GKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTH 364
            |::|.:|.:|...|..||..:.|.|:||.|:.|.|:||.|:|...|..:.|::.||||:||:|..
Human   395 GEKPFECLECGKAFNHRSYLKRHQRIHTGEKPYVCSECGKAFTHCSTFILHKRAHTGEKPFECKE 459

  Fly   365 CFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSS 429
            |.|.|..|..|..|...|.|||..:|..|.|.|...|.|..|.:.|:|:..:||..|.|::..|:
Human   460 CGKAFSNRADLIRHFSIHTGEKPYECMECGKAFNRRSGLTRHQRIHSGEKPYECIECGKTFCWST 524

  Fly   430 TLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYT--------QKSS 486
            .|..|...||||.|::||.|.|.|:||:...:|.|.|||..|...:.....:|        |:..
Human   525 NLIRHSIIHTGEKPYECSECGKAFSRSSSLTQHQRMHTGRNPISVTDVGRPFTSGQTSVNIQELL 589

  Fly   487 LGRH 490
            ||::
Human   590 LGKN 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	148/405 (37%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	3/19 (16%)
		C2H2 Zn finger	167..187	CDD:275368	10/19 (53%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..492	CDD:275368	4/25 (16%)
ZNF805	NP_001018857.2	KRAB	13..73	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..95
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..162
		C2H2 Zn finger	205..225	CDD:275368	8/19 (42%)
		zf-H2C2_2	218..242	CDD:463886	10/23 (43%)
		C2H2 Zn finger	233..253	CDD:275368	8/46 (17%)
		COG5048	257..>580	CDD:227381	123/322 (38%)
		C2H2 Zn finger	261..281	CDD:275368	10/19 (53%)
		C2H2 Zn finger	289..309	CDD:275368	8/19 (42%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		C2H2 Zn finger	541..561	CDD:275368	9/19 (47%)