DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF761

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001008401.3	Gene:	ZNF761 / 388561	HGNCID:	23179	Length:	746	Species:	Homo sapiens

Alignment Length:	465	Identity:	184/465 - (39%)
Similarity:	259/465 - (55%)	Gaps:	30/465 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRR 122
            |..||...|..:|..|......:.:||.:|.|||::..:|..|.|||..|:|::|..|.|:|..:
Human   246 VCGKLFNQKRNLACHRRCHTGENPYKCNECGKTFSQTSSLTCHRRLHTGEKPYKCEECDKAFHFK 310

  Fly   123 THYKRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRT 186
            :..:||.:.| |::|:||:.|.|||.|.|.|.:|...||||:|:||.:|..:|:.||.|..|.|.
Human   311 SILERHRIIHTEEKPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNECGKTFSHKSSLTCHHRL 375

  Fly   187 HSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAE-RSFKC 250
            |:.|:|::|..|.|.|.:.|.|..|.|.|...:|:||..|.|::..||..:.|...|.| .::||
Human   376 HTGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKC 440

  Fly   251 TQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAM 315
            .:|.|||.:..||..|.|.|.||.|:||..|.:.|...|.|:.|...|.|::|.||::|..||:.
Human   441 NECGKTFSRTSSLTCHRRRHTGEQPYKCEECDKAFRFKSNLERHRRIHTGEKPYKCNECGKTFSR 505

  Fly   316 RSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDF----------- 369
            :|....|.||||.|:.|||.||.|:|..||.|..|:::|:||:|:||..|.|.|
Human   506 KSYLTCHHRLHTGEKAYKCNECGKTFSWKSSLTCHRRLHSGEKPYKCKECGKTFNQQLTLKRHRR 570

  Fly   370 --------KC---------RTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFE 417
                    ||         :::|.:|...|..|...||:.|.|.|..:|.|..|.:.|||:..::
Human   571 LHSGENPYKCEDSDKAYSFKSNLEIHQKIHTEENPYKCNECGKTFSRTSSLTCHRRLHTGEKPYK 635

  Fly   418 CPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYT 482
            |..|.|::...|.|..|.|.||||.|:||:.|.|.|:|.:....|.|.|||||||||:.|...::
Human   636 CEECDKAFRVKSNLEGHRRIHTGEKPYKCNECGKTFSRKSYFICHHRLHTGEKPYKCNECGKNFS 700

  Fly   483 QKSSLGRHLR 492
            |||||..|.|
Human   701 QKSSLICHHR 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	170/433 (39%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	8/47 (17%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	8/17 (47%)
ZNF761	NP_001008401.3	KRAB	7..48	CDD:307490
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	242..617	CDD:227381	141/370 (38%)
		C2H2 Zn finger	244..264	CDD:275368	6/17 (35%)
		C2H2 Zn finger	272..292	CDD:275368	8/19 (42%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	328..348	CDD:275368	9/19 (47%)
		C2H2 Zn finger	356..376	CDD:275368	8/19 (42%)
		C2H2 Zn finger	384..404	CDD:275368	8/19 (42%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	9/19 (47%)
		C2H2 Zn finger	552..572	CDD:275368	4/19 (21%)
		C2H2 Zn finger	580..600	CDD:275368	3/19 (16%)
		C2H2 Zn finger	608..628	CDD:275368	7/19 (37%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		SFP1	<651..737	CDD:227516	32/60 (53%)
		C2H2 Zn finger	664..684	CDD:275368	7/19 (37%)
		C2H2 Zn finger	692..712	CDD:275368	9/19 (47%)
		C2H2 Zn finger	720..740	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900