Protein Alignment CG5245 and ZNF808

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001034975.2
• Gene: ZNF808 / 388558
• HGNCID: 33230
• Length: 903
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 173/443 - (39%)
• Similarity: 262/443 - (59%)
• Gaps: 14/443 - (3%)

  Fly    59 PSKLK------TCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSK 117
            |.|.|      ||.|::|:.|.:.....|:||.:|:|||:|:.:|..|.|||:.|:|::|:.|..
Human   454 PYKCKVCDTAFTCNSQLARHRRIHTGEKTYKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGN 518

  Fly   118 SFGRRT----HYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKS 178
            :|..|.    |.:.|.|   ::.:||:.|:|.|.:||.|..|...||.::|:||.:|..:|.::|
Human   519 TFRHRASLVYHRRLHTL---EKSYKCTVCNKVFMRNSVLAVHTRIHTAKKPYKCNECGKAFNQQS 580

  Fly   179 HLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH 243
            ||..|.|.|:.|:|::|..|:|.|...|.|:.|.|.|...:|::|..|..:|...|.|.:|...|
Human   581 HLSRHRRLHTGEKPYKCEACDKVFGQKSALESHKRIHTGEKPYRCQVCDTAFTWNSQLARHTRIH 645

  Fly   244 -AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCS 307
             .|:::||.:|.|||....||..|.|:|.||..:||..|.:.|...|.:..|...|:|.:|.||:
Human   646 TGEKTYKCNECGKTFSYKSSLVWHRRLHGGEKSYKCKVCDKAFVCRSYVAKHTRIHSGMKPYKCN 710

  Fly   308 QCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCR 372
            :||.||:.||....|.|:|:.|:.|||:||||:|.:|:.|:.|:::|:||:|:||..|...|:..
Human   711 ECSKTFSNRSSLVCHRRIHSGEKPYKCSECSKTFSQKATLLCHRRLHSGEKPYKCNDCGNTFRHW 775

  Fly   373 THLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRT 437
            :.|..|...|.|||..||:.|.|.|..:|.|..|::.||.:..::|..|.|::...|.|..|.|.
Human   776 SSLVYHRRLHTGEKSYKCTVCDKAFVRNSYLARHIRIHTAEKPYKCNECGKAFNEQSHLSRHHRI 840

  Fly   438 HTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            ||||.|:||..|.|:|:|.:..:.|...|||||||||:.|...::.:|:|..|
Human   841 HTGEKPYKCEACDKVFSRKSHLKRHRIIHTGEKPYKCNECGKAFSDRSTLIHH 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/408 (39%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	7/23 (30%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	9/19 (47%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF808	NP_001034975.2	KRAB	24..60	CDD:460171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..154
		COG5048	206..585	CDD:227381	49/133 (37%)
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	261..281	CDD:275368
		C2H2 Zn finger	289..309	CDD:275368
		C2H2 Zn finger	317..337	CDD:275368
		C2H2 Zn finger	345..365	CDD:275368
		C2H2 Zn finger	373..393	CDD:275368
		COG5048	397..839	CDD:227381	147/387 (38%)
		C2H2 Zn finger	401..421	CDD:275368
		C2H2 Zn finger	429..449	CDD:275368
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		C2H2 Zn finger	485..505	CDD:275368	9/19 (47%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		C2H2 Zn finger	541..561	CDD:275368	8/19 (42%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		C2H2 Zn finger	597..617	CDD:275368	8/19 (42%)
		C2H2 Zn finger	625..645	CDD:275368	6/19 (32%)
		C2H2 Zn finger	653..673	CDD:275368	9/19 (47%)
		C2H2 Zn finger	681..701	CDD:275368	5/19 (26%)
		C2H2 Zn finger	709..729	CDD:275368	9/19 (47%)
		C2H2 Zn finger	737..757	CDD:275368	9/19 (47%)
		C2H2 Zn finger	765..785	CDD:275368	5/19 (26%)
		C2H2 Zn finger	793..813	CDD:275368	7/19 (37%)
		C2H2 Zn finger	821..841	CDD:275368	7/19 (37%)
		zf-H2C2_2	833..858	CDD:463886	13/24 (54%)
		C2H2 Zn finger	849..869	CDD:275368	6/19 (32%)
		zf-H2C2_2	861..885	CDD:463886	11/23 (48%)
		C2H2 Zn finger	877..897	CDD:275368	5/17 (29%)