Protein Alignment CG5245 and ZNF728

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001254645.1
• Gene: ZNF728 / 388523
• HGNCID: 32463
• Length: 622
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 184/549 - (33%)
• Similarity: 268/549 - (48%)
• Gaps: 61/549 - (11%)

  Fly     5 NVDQRPVKDEPP---------------QEDTFEEELI-FISNSDFEELESEIKIENF--C----- 46
            |:.:..:..|||               :||:|::.:: .......|.|:.:|...|.  |
Human    64 NMKRHELVKEPPVICSHFAQDLWPEQGREDSFQKVILRRYEKCGHENLQLKIGCTNVDECKVHKK 128

  Fly    47 SYGKDLEPVKGVPSKLKTC--------KSKIAKKRPLRKQ-TDTFKC-------------TQCQK 89
            .|.|..:.:....||:..|        |...:|:..:|.. ....||             :|.::
Human   129 GYNKLNQSLTTTQSKVFQCGKYANIFHKCSNSKRHKIRHTGKKLLKCKEYVRSFCMLSHLSQHKR 193

  Fly    90 TFTRKENLES--------------HLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPH-KC 139
            .:||:.:.:|              :.|:|..|:|.:|..|.|:|.:.:...:|.:.|....| ||
Human   194 IYTRENSYKSEEHGKAFNWSSALTYKRIHTGEKPCKCEECGKAFSKFSILTKHKVIHTGEKHYKC 258

  Fly   140 SHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKN 204
            ..|.|.||::|||.:|...|.||:|:||.:|..:|::.|.|..|...|:.|:|::|..|.|||..
Human   259 EECGKAFTRSSSLIEHKRSHAGEKPYKCEECGKAFSKASTLTAHKTIHAGEKPYKCEECGKAFNR 323

  Fly   205 NSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLR 268
            :|:|.||.|.|...:|.||..|.|:|...|.|.||.:.| .|:.:||.:|.|.|....||..|.|
Human   324 SSNLMEHKRIHTGEKPCKCEECGKAFGNFSTLTKHKVIHTGEKPYKCEECGKAFSWPSSLTEHKR 388

  Fly   269 VHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYK 333
            :|||:.|:||..|.:||..:|.|..|.:.|.|::|.||.:|...|...|....|..:||.|:.||
Human   389 IHAGDKPYKCEECGKTFKWSSTLTKHKIIHTGEKPYKCEECGKAFTTFSSLTKHKVIHTGEKHYK 453

  Fly   334 CAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFK 398
            |.||.|.|...|.|..|:.:|.||:.:||..|.|.||..::|..|...|.|||..||..|.|.|.
Human   454 CEECGKVFSWSSSLTTHKAIHAGEKLYKCEECGKAFKWSSNLMEHKRIHTGEKPYKCEECGKAFS 518

  Fly   399 LSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHL 463
            ..:.|..|...|||:.|::|..|.|::..||.|..|.|.||||.|:||..|.|.|:..:...:|.
Human   519 KVANLTKHKVIHTGEKQYKCEECGKAFIWSSRLSEHKRIHTGEKPYKCEECGKAFSWVSVLNKHK 583

  Fly   464 RTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            :.|.|:|.|||..|...:.|.|.|..|.|
Human   584 KIHAGKKFYKCEECGKDFNQSSHLTTHKR 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	159/433 (37%)
		C2H2 Zn finger	84..104	CDD:275368	6/46 (13%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF728	NP_001254645.1	KRAB	4..64	CDD:214630	184/549 (34%)
		C2H2 Zn finger	146..167	CDD:275370	3/20 (15%)
		C2H2 Zn finger	175..195	CDD:275368	2/19 (11%)
		COG5048	<185..360	CDD:227381	60/174 (34%)
		C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	258..278	CDD:275368	9/19 (47%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		COG5048	310..>606	CDD:227381	120/295 (41%)
		C2H2 Zn finger	314..334	CDD:275368	10/19 (53%)
		C2H2 Zn finger	342..362	CDD:275368	8/19 (42%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
		C2H2 Zn finger	398..418	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..446	CDD:275368	5/19 (26%)
		C2H2 Zn finger	454..474	CDD:275368	8/19 (42%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		C2H2 Zn finger	538..558	CDD:275368	8/19 (42%)
		C2H2 Zn finger	566..586	CDD:275368	5/19 (26%)
		C2H2 Zn finger	594..614	CDD:275368	7/19 (37%)