DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zkscan7

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001170976.1	Gene:	Zkscan7 / 382118	MGIID:	3040678	Length:	718	Species:	Mus musculus

Alignment Length:	433	Identity:	153/433 - (35%)
Similarity:	232/433 - (53%)	Gaps:	19/433 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 CKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHL 129
            ||..:|::   .:.....:.:..:..|..||:..|     .|:|..||    |..|.........
Mouse   285 CKDPLAQR---EEHPSDEEGSGLESDFLEKEDKNS-----TEDRNEEC----KDVGVHPEMPSSP 337

  Fly   130 LKHE-----KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSE 189
            ::|:     ::.::|..|.|.|:|:|....|...|.|||||:|.:|..:|.:.|.|.||||.|::
Mouse   338 VEHQGEAKRQKSYQCDECGKVFSQSSRFLGHQRIHVGERPFECNKCGKTFQQISQLVVHLRIHTQ 402

  Fly   190 ERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERSFKCTQCP 254
            |:|:||....|.:.::|||.:|.|.....:|:|.:.|.::....|.|..|..||...  |..:..
Mouse   403 EKPYECCESGKTYCHSSHLIQHQRLRNGDKPYKGNECVRASIQSSQLLVHKRTHTGE--KPDESG 465

  Fly   255 KTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLY 319
            :.|:.|.||..|..:|..:..::|..|.:.|..|..|..|...|.|::|.:|.:|..:|:.....
Mouse   466 EAFIWNKSLIQHQVLHISKKLYECNECGKAFYTNRNLIDHQRIHTGEKPYECIECGKSFSRSKCL 530

  Fly   320 RVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIG 384
            ..|..|||.|:.|||:||.|:|.:.|.|::|::|||||:||:|:.|.|.|.....|..|...|.|
Mouse   531 TRHQSLHTGEKTYKCSECGKAFLQNSQLIDHKRVHTGEKPFECSECGKKFSLGKCLIRHQRLHTG 595

  Fly   385 EKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHC 449
            ||..|||.|.|.|..:|.|::|.:.|||:..:.|..|.|.::.||:|.:|.||||||.|:||..|
Mouse   596 EKPYKCSECGKSFNQNSHLIIHQRIHTGEKPYGCNECGKVFSYSSSLMVHQRTHTGEKPYKCKDC 660

  Fly   450 SKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|.|..|::...|.|.|||||||:|:.|...::|:|:...|.|
Mouse   661 MKAFGDSSQLIVHQRVHTGEKPYECAECGKAFSQRSTFNHHQR 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	145/408 (36%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	3/19 (16%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	4/19 (21%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zkscan7	NP_001170976.1	SCAN	46..156	CDD:128708
		SCAN	46..133	CDD:280241
		COG5048	333..702	CDD:227381	138/370 (37%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		zf-H2C2_2	368..387	CDD:290200	9/18 (50%)
		C2H2 Zn finger	380..400	CDD:275368	9/19 (47%)
		C2H2 Zn finger	408..427	CDD:275368	6/18 (33%)
		C2H2 Zn finger	437..453	CDD:275368	3/15 (20%)
		zf-C2H2	487..509	CDD:278523	6/21 (29%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		zf-H2C2_2	501..526	CDD:290200	8/24 (33%)
		C2H2 Zn finger	517..537	CDD:275368	4/19 (21%)
		zf-H2C2_2	530..554	CDD:290200	12/23 (52%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		zf-H2C2_2	561..581	CDD:290200	11/19 (58%)
		C2H2 Zn finger	573..593	CDD:275368	6/19 (32%)
		zf-H2C2_2	586..610	CDD:290200	12/23 (52%)
		C2H2 Zn finger	601..621	CDD:275368	8/19 (42%)
		zf-H2C2_2	613..638	CDD:290200	8/24 (33%)
		C2H2 Zn finger	629..649	CDD:275368	8/19 (42%)
		zf-H2C2_2	641..664	CDD:290200	13/22 (59%)
		C2H2 Zn finger	657..677	CDD:275368	7/19 (37%)
		zf-H2C2_2	670..694	CDD:290200	11/23 (48%)
		C2H2 Zn finger	685..705	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900