DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF699

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_940937.1	Gene:	ZNF699 / 374879	HGNCID:	24750	Length:	642	Species:	Homo sapiens

Alignment Length:	458	Identity:	165/458 - (36%)
Similarity:	255/458 - (55%)	Gaps:	32/458 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SKIAKKRPLRKQTD--TFKCTQCQKTFTRKENLESHLRLH------------------------- 104
            |::.....|::.|:  :.:|.:|.|.|....:|:||:|.|
Human   178 SQVPNLDSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKKHM 242

  Fly   105 ---AEERPFECSHCSKSFGRRTHYKRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPF 165
               .||:|:||..|:|:|...:.::.|:..| .|..::|..|.|.|:.:|||.:|...|:|::|:
Human   243 KTPTEEKPYECKECTKAFSCSSFFRAHMKIHIGKTNYECKECGKGFSCSSSLTEHKRIHSGDKPY 307

  Fly   166 KCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSF 230
            :|.:|..:|:..|.|..|.|.||.::|:||..|.|||.::|||..|:|.|...:|::|..|.|:|
Human   308 ECKECGKAFSCSSSLSKHKRIHSGDKPYECKECGKAFSSSSHLIIHIRIHTGEKPYECKECGKAF 372

  Fly   231 KLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLH 294
            ...|.|..|..|| .|:.:||.:|.|.:....||.||:|.|.||.|::|..|.:.|...:.|..|
Human   373 SESSKLTVHGRTHTGEKPYKCKECGKAYNCPSSLSIHMRKHTGEKPYECLECGKAFYLPTSLNTH 437

  Fly   295 LLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERP 359
            :...:.::|.:|.:|...|:..|.:|.|||.||.:.||:|.||.|:|.:.|.|.||.:.|:||:|
Human   438 VKNQSREKPYECKECGKAFSCPSSFRAHVRDHTGKIQYECKECGKTFSRSSSLTEHLRTHSGEKP 502

  Fly   360 FKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKS 424
            ::|..|.|.|...:||.||:..|.|||..:|..|.|.|...|.|.:|::.|||:..:||..|.|:
Human   503 YECKECGKAFISSSHLTVHIRTHTGEKPYECKKCGKAFIYPSALRIHMRTHTGEKPYECKECGKA 567

  Fly   425 YTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGR 489
            :..||.|.:|.|.||||.||:|..|.|.|:..:..:.|:|:|||||||:|..|...:...:...|
Human   568 FRHSSYLTVHARMHTGEKPFECLECGKAFSCPSSFRRHVRSHTGEKPYECKECGKAFVCPAYFRR 632

  Fly   490 HLR 492
            |::
Human   633 HVK 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/435 (37%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	4/17 (24%)
ZNF699	NP_940937.1	KRAB	19..79	CDD:214630
		KRAB	19..58	CDD:279668
		C2H2 Zn finger	143..159	CDD:275368
		C2H2 Zn finger	167..189	CDD:275368	2/10 (20%)
		COG5048	171..605	CDD:227381	152/426 (36%)
		C2H2 Zn finger	197..217	CDD:275368	8/19 (42%)
		zf-H2C2_2	209..233	CDD:290200	5/23 (22%)
		C2H2 Zn finger	225..245	CDD:275368	0/19 (0%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		zf-H2C2_2	293..318	CDD:290200	9/24 (38%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		zf-H2C2_2	321..346	CDD:290200	12/24 (50%)
		C2H2 Zn finger	337..357	CDD:275368	10/19 (53%)
		zf-H2C2_2	349..373	CDD:290200	9/23 (39%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		zf-H2C2_2	405..428	CDD:290200	11/22 (50%)
		C2H2 Zn finger	421..439	CDD:275368	5/17 (29%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		zf-C2H2	475..497	CDD:278523	10/21 (48%)
		C2H2 Zn finger	477..497	CDD:275368	9/19 (47%)
		zf-H2C2_2	489..514	CDD:290200	11/24 (46%)
		C2H2 Zn finger	505..525	CDD:275368	8/19 (42%)
		zf-H2C2_2	517..542	CDD:290200	12/24 (50%)
		C2H2 Zn finger	533..553	CDD:275368	7/19 (37%)
		zf-H2C2_2	545..570	CDD:290200	9/24 (38%)
		C2H2 Zn finger	561..581	CDD:275368	8/19 (42%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		zf-H2C2_2	601..626	CDD:290200	11/24 (46%)
		C2H2 Zn finger	617..637	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910