Protein Alignment CG5245 and ZNF81

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_009068.2
• Gene: ZNF81 / 347344
• HGNCID: 13156
• Length: 661
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 166/481 - (34%)
• Similarity: 250/481 - (51%)
• Gaps: 18/481 - (3%)

  Fly    15 PPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQT 79
            |.:.|:|.:.  |..|.|       :.|.|..:..|:|:...| ..::.|..|..:.........
Human   189 PHKRDSFGKS--FKHNLD-------LHIHNKSNAAKNLDKTIG-HGQVFTQNSSYSHHENTHTGV 243

  Fly    80 DTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHY----KRHLLKHEKRPHKCS 140
            ...:..||.|..:.|.:|..:::....|:...|:...|.|.:|:|:    |.|.:   ::||:.|
Human   244 KFCERNQCGKVLSLKHSLSQNVKFPIGEKANTCTEFGKIFTQRSHFFAPQKIHTV---EKPHELS 305

  Fly   141 HCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNN 205
            .|...|||...|..:|..|..|:.:.||:|..:|.:.|.|.:|.:||:.|:|::|..|.|:|...
Human   306 KCVNVFTQKPLLSIYLRVHRDEKLYICTKCGKAFIQNSELIMHEKTHTREKPYKCNECGKSFFQV 370

  Fly   206 SHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRV 269
            |.|..|..||...:.|:||.|.|.|.|.|.|..|...| .||..||::|.|.|.|..:|::|.|:
Human   371 SSLLRHQTTHTGEKLFECSECGKGFSLNSALNIHQKIHTGERHHKCSECGKAFTQKSTLRMHQRI 435

  Fly   270 HAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKC 334
            |.||..:.|..|.:.|.:.:.|..|...|.|::|.:||.|..:|..:|..::|.|:||.|:.|.|
Human   436 HTGERSYICTQCGQAFIQKAHLIAHQRIHTGEKPYECSDCGKSFPSKSQLQMHKRIHTGEKPYIC 500

  Fly   335 AECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKL 399
            .||.|:|..:|:|..||:.||||:.:.|..|.|.|..|::...|...|.|||...|:.|.:.|..
Human   501 TECGKAFTNRSNLNTHQKSHTGEKSYICAECGKAFTDRSNFNKHQTIHTGEKPYVCADCGRAFIQ 565

  Fly   400 SSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLR 464
            .|:|:.|.:.||.:..::||.|.||::....|.:|.|.||||.|:.|:.|.|.|...:...:|..
Human   566 KSELITHQRIHTTEKPYKCPDCEKSFSKKPHLKVHQRIHTGEKPYICAECGKAFTDRSNFNKHQT 630

  Fly   465 THTGEKPYKCSHCSTRYTQKSSLGRH 490
            .|||:||||||.|...:||||.|..|
Human   631 IHTGDKPYKCSDCGKGFTQKSVLSMH 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	146/408 (36%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	7/23 (30%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..492	CDD:275368	9/17 (53%)
ZNF81	NP_009068.2	KRAB	21..81	CDD:214630
		C2H2 Zn finger	249..268	CDD:275368	5/18 (28%)
		C2H2 Zn finger	276..296	CDD:275368	6/19 (32%)
		C2H2 Zn finger	307..324	CDD:275368	6/16 (38%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		COG5048	356..>651	CDD:227381	115/294 (39%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		C2H2 Zn finger	444..464	CDD:275368	5/19 (26%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
		C2H2 Zn finger	500..520	CDD:275368	9/19 (47%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		C2H2 Zn finger	556..576	CDD:275368	6/19 (32%)
		C2H2 Zn finger	584..604	CDD:275368	8/19 (42%)
		C2H2 Zn finger	612..632	CDD:275368	5/19 (26%)
		C2H2 Zn finger	640..660	CDD:275368	9/17 (53%)