Protein Alignment CG5245 and ZNF879

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001129588.1
• Gene: ZNF879 / 345462
• HGNCID: 37273
• Length: 563
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 185/549 - (33%)
• Similarity: 269/549 - (48%)
• Gaps: 79/549 - (14%)

  Fly    20 TFEEELIFISNSDFEELES-------EIKIENF------------------CSYGKDLEPVK-GV 58
            ||.:..:|.|..::..|:|       |:.:||:                  ...|:|...|: ||
Human    15 TFRDVAVFFSQDEWLHLDSAQRALYREVMLENYSILVSLGILFSKPKVISQLEQGEDPWMVESGV 79

  Fly    59 P--------SKLKTCKSKIAKKRPLRK----QTDTFKCTQCQKTFTRKENLESH----------- 100
            |        |...|..||...:..::|    .|..||   .:||:..::.||..
Human    80 PQGAHLGWESLFGTIVSKEENQEVMKKLIIDGTFDFK---LEKTYINEDKLEKQQGKKNRLFSKV 141

  Fly   101 ----LRLHAEERPFECSHCSKSFGRRTHY--KRHLLKHEKRP--------------------HKC 139
                .:::.:||.|:.....|:.|.::..  |..::...:||                    :||
Human   142 LVTIKKVYMKERSFKGVEFGKNLGLKSSLIRKPRIVSRGRRPRSQQYSVLFKQLGVNTVRKCYKC 206

  Fly   140 SHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKN 204
            :.|.|.|..:|||.:|...||||:.:||.:|..:|::.|.|..|||.|:.|:|:.|:.|.|||..
Human   207 NICGKIFLHSSSLSKHQRIHTGEKLYKCKECRKAFSQSSSLTQHLRVHTGEKPYICSECGKAFSF 271

  Fly   205 NSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLR 268
            .:.|..|.|.|...||:||..|.|:||..|.|..|...| .|:.:||.:|.:.|.|..||..|.|
Human   272 TTSLIGHQRMHTGERPYKCKECGKTFKGSSSLNNHQRIHTGEKPYKCNECGRAFSQCSSLIQHHR 336

  Fly   269 VHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYK 333
            :|.||.|::|..|.:.|...|||..|...|.|::|..|::|...|:..|...:|.|:||.|:.|.
Human   337 IHTGEKPYECTQCGKAFTSISRLSRHHRIHTGEKPFHCNECGKVFSYHSALIIHQRIHTGEKPYA 401

  Fly   334 CAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFK 398
            |.||.|:|.:.|.|::||::||||:|:||..|.|.|...:.|.:|...|.|||...|..|.|.|.
Human   402 CKECGKAFSQSSALIQHQRIHTGEKPYKCNECGKAFSWISRLNIHHRIHTGEKPYNCKECGKAFS 466

  Fly   399 LSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHL 463
            ..|.:..|.:.|||:..::|..|.|::..||.|..|.|.||||.|:.|..|.|.|.:|:....|:
Human   467 SHSGVNTHRKIHTGEKPYKCNDCEKAFNQSSALIQHQRIHTGEKPYNCKVCGKAFRQSSSLMTHM 531

  Fly   464 RTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            |.|||||||||..|...::|.|||..|.|
Human   532 RIHTGEKPYKCKECGKAFSQSSSLTNHQR 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	159/445 (36%)
		C2H2 Zn finger	84..104	CDD:275368	4/34 (12%)
		C2H2 Zn finger	112..132	CDD:275368	3/21 (14%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
ZNF879	NP_001129588.1	KRAB	14..74	CDD:214630	11/58 (19%)
		COG5048	202..558	CDD:227381	148/355 (42%)
		C2H2 Zn finger	206..226	CDD:275368	8/19 (42%)
		C2H2 Zn finger	234..254	CDD:275368	8/19 (42%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		C2H2 Zn finger	290..310	CDD:275368	8/19 (42%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		C2H2 Zn finger	346..366	CDD:275368	7/19 (37%)
		C2H2 Zn finger	374..394	CDD:275368	6/19 (32%)
		C2H2 Zn finger	402..422	CDD:275368	9/19 (47%)
		C2H2 Zn finger	430..450	CDD:275368	6/19 (32%)
		C2H2 Zn finger	458..478	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..506	CDD:275368	8/19 (42%)
		C2H2 Zn finger	514..534	CDD:275368	7/19 (37%)
		C2H2 Zn finger	542..562	CDD:275368	8/19 (42%)