DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF260

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001012774.1	Gene:	ZNF260 / 339324	HGNCID:	13499	Length:	412	Species:	Homo sapiens

Alignment Length:	393	Identity:	147/393 - (37%)
Similarity:	226/393 - (57%)	Gaps:	15/393 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKT 145
            ::|.:|:|||:.|:||..|.::|..|:..||:.|.|...|.:....||..|. |:.:||:.|.|.
Human    27 YECNECRKTFSLKQNLVEHKKMHTGEKSHECTECGKVCSRVSSLTLHLRSHTGKKAYKCNKCGKA 91

  Fly   146 FTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQV-----HLRTHSEERPFECTHCEKAFKNN 205
            |:|..:...|...||||:|::|.:.|        :|:     |.:.|:..:|:.|..|.|||...
Human    92 FSQKENFLSHQKHHTGEKPYECEKVS--------IQMPTIIRHQKNHTGTKPYACKECGKAFNGK 148

  Fly   206 SHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRV 269
            ::|.||.:.|...:||:|:.|.::|..:..|.||...| .::.|||::|.|.|.|.::|.||.|:
Human   149 AYLTEHEKIHTGEKPFECNQCGRAFSQKQYLIKHQNIHTGKKPFKCSECGKAFSQKENLIIHQRI 213

  Fly   270 HAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKC 334
            |.||.|::|..|.:.|.:.|.|..|...|.|::|..|.:|...|:.:|....|.::|..|:.|||
Human   214 HTGEKPYECKGCGKAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKSNLTEHEKIHIGEKPYKC 278

  Fly   335 AECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKL 399
            .||...|.:|.:|::|..:||||:|::|..|.|.|...|.|.||:..|.|:|..:|..|.|.|..
Human   279 NECGTIFRQKQYLIKHHNIHTGEKPYECNKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQ 343

  Fly   400 SSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLR 464
            ||.|.||::.|||:..:.|..|.|:::..|||.:|:|.||||.|::||.|.|.|::.:.|..|.|
Human   344 SSSLTVHMRSHTGEKPYGCNECGKAFSQFSTLALHMRIHTGEKPYQCSECGKAFSQKSHHIRHQR 408

  Fly   465 THT 467
            .||
Human   409 IHT 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	147/393 (37%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	4/24 (17%)
		zf-H2C2_2	179..204	CDD:290200	9/29 (31%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368
ZNF260	NP_001012774.1	COG5048	25..406	CDD:227381	143/386 (37%)
		C2H2 Zn finger	29..49	CDD:275368	9/19 (47%)
		C2H2 Zn finger	57..77	CDD:275368	6/19 (32%)
		C2H2 Zn finger	85..130	CDD:275368	15/52 (29%)
		C2H2 Zn finger	138..158	CDD:275368	8/19 (42%)
		C2H2 Zn finger	166..186	CDD:275368	6/19 (32%)
		C2H2 Zn finger	194..214	CDD:275368	9/19 (47%)
		C2H2 Zn finger	222..242	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900