DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp78

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001020334.1	Gene:	Zfp78 / 330463	MGIID:	107783	Length:	512	Species:	Mus musculus

Alignment Length:	469	Identity:	152/469 - (32%)
Similarity:	231/469 - (49%)	Gaps:	63/469 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQ 88
            :|:|          .::.:||..|.|               |:|..:.::  :|..|.......|
Mouse   100 QLVF----------EDVAVENTTSLG---------------CESLTSGRK--QKCKDLLDRQMSQ 137

  Fly    89 KTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLK 153
            :.|..||.: :|...|.:|..::.:...||        .||...|:..:......|:|::|..:.
Mouse   138 EIFNLKETV-THKGTHTKEIGYKHTESLKS--------AHLDSVEENIYTHKSNKKSFSKNPKVW 193

  Fly   154 QHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEA 218
            ::.....|:..|||.:|..:|...|.:.||.|.|:.|:|::||.|.||||.:.||.:|..||
Mouse   194 KYKKIWAGKTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQSHHLAQHHTTH--- 255

  Fly   219 RPFKCSHCSKSFKLRSILQKHLLTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSE 283
                                   || |:.|:|.:|.|.|.||..|.:|.|:|.||.|:||..|::
Mouse   256 -----------------------TH-EKLFQCEECKKAFSQNSYLTVHRRIHTGEKPYKCKECAK 296

  Fly   284 TFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLV 348
            :|.:.:.|..|...|.|::|.||..|...|........|.|:|:.|:.|||.:|.|:|.:..|||
Mouse   297 SFRQPAHLAQHHRIHTGEKPYKCEICGKAFNHSMSLTGHQRVHSGEKPYKCKDCGKAFRQSIHLV 361

  Fly   349 EHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGK 413
            .|.::||||.|::|..|.|.|:..:.|.:|..:|.|||..:|..|.|.|..|:.|..|.:.|||:
Mouse   362 VHSRIHTGEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAYLARHQKIHTGE 426

  Fly   414 NQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCS 478
            ..:||..|.|::|.::.|..|.|.||||.|:||:.|.|.|...:...:|.|.|||::||.|..|.
Mouse   427 KPYECNECGKTFTHAAYLIRHKRVHTGEKPYKCAECGKAFGDGSSRAQHQRLHTGQRPYVCEKCG 491

  Fly   479 TRYTQKSSLGRHLR 492
            ..:.:||||..|.|
Mouse   492 RAFRRKSSLNCHQR 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	137/403 (34%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	4/19 (21%)
		C2H2 Zn finger	139..159	CDD:275368	3/19 (16%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	0/19 (0%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
Zfp78	NP_001020334.1	KRAB	14..73	CDD:214630
		COG5048	202..>487	CDD:227381	118/311 (38%)
		C2H2 Zn finger	207..227	CDD:275368	7/19 (37%)
		C2H2 Zn finger	235..255	CDD:275368	10/19 (53%)
		C2H2 Zn finger	263..283	CDD:275368	9/19 (47%)
		C2H2 Zn finger	291..311	CDD:275368	5/19 (26%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		C2H2 Zn finger	347..367	CDD:275368	8/19 (42%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		C2H2 Zn finger	459..479	CDD:275368	6/19 (32%)
		C2H2 Zn finger	487..507	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900