Protein Alignment CG5245 and ZNF454

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_872400.2
• Gene: ZNF454 / 285676
• HGNCID: 21200
• Length: 522
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 168/496 - (33%)
• Similarity: 247/496 - (49%)
• Gaps: 56/496 - (11%)

  Fly    16 PQEDTFEEELIFISNSDFEELE---SEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRK 77
            |:.|||         |..|:.|   .|.....||     |:.:....||..|.|::|.:     :
Human    58 PKPDTF---------SQLEKREVWMPEDTPGGFC-----LDWMTMPASKKSTVKAEIPE-----E 103

  Fly    78 QTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHC 142
            :.|       |.|...:.:..||.:. |....::|.      |:....:|.:|.|...|.:  .|
Human   104 ELD-------QWTIKERFSSSSHWKC-ASLLEWQCG------GQEISLQRVVLTHPNTPSQ--EC 152

  Fly   143 SKT-FTQNSSLKQHLHEHTGERP----FKCTQCSTSFARKSHLQVHLRTHSE----------ERP 192
            .:: .|.:|||  |..:..|.:|    |:|::|...|::.|.|..|.:.|:|          |:.
Human   153 DESGSTMSSSL--HSDQSQGFQPSKNAFECSECGKVFSKSSTLNKHQKIHNEKNANQKIHIKEKR 215

  Fly   193 FECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKT 256
            :||..|.|||..::||..|.|.|...:|::|..|.|:|.:.|.|..|...| .|:.|:|..|.|.
Human   216 YECRECGKAFHQSTHLIHHQRIHTGEKPYECKECGKAFSVSSSLTYHQKIHTGEKPFECNLCGKA 280

  Fly   257 FLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRV 321
            |::|..|..|.|:|.||.||||..|.:.|...:.|..|...|:|::|.||::|...|...:.:..
Human   281 FIRNIHLAHHHRIHTGEKPFKCNICEKAFVCRAHLTKHQNIHSGEKPYKCNECGKAFNQSTSFLQ 345

  Fly   322 HVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEK 386
            |.|:||.|:.::|.||.|:|...|.|.|||::||||:|:||..|.|.|:..:....|...|.|||
Human   346 HQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPYKCNECGKAFRDNSSFARHRKIHTGEK 410

  Fly   387 VPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSK 451
            ..:|..|.|.|:..|.|..|.:.|||:..:.|..|.|:::..|.|..|.|.||.|.|:||..|.|
Human   411 PYRCGLCEKAFRDQSALAQHQRIHTGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKICEK 475

  Fly   452 LFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|.||....:|.|.|||||||||:.|...:.|.::|.:|.|
Human   476 AFIRSTHLTQHQRIHTGEKPYKCNKCGKAFNQTANLIQHQR 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	147/419 (35%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	4/19 (21%)
		C2H2 Zn finger	139..159	CDD:275368	6/20 (30%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF454	NP_872400.2	KRAB	14..73	CDD:214630	7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..170		7/26 (27%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	186..522	CDD:227381	129/331 (39%)
		C2H2 Zn finger	218..238	CDD:275368	9/19 (47%)
		C2H2 Zn finger	246..266	CDD:275368	7/19 (37%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		C2H2 Zn finger	358..378	CDD:275368	10/19 (53%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		C2H2 Zn finger	470..490	CDD:275368	8/19 (42%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)