DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5245 and ZNF454

DIOPT Version :9

Sequence 1:NP_650197.1 Gene:CG5245 / 41530 FlyBaseID:FBgn0038047 Length:501 Species:Drosophila melanogaster
Sequence 2:NP_001171560.1 Gene:ZNF454 / 285676 HGNCID:21200 Length:522 Species:Homo sapiens


Alignment Length:496 Identity:168/496 - (33%)
Similarity:247/496 - (49%) Gaps:56/496 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 PQEDTFEEELIFISNSDFEELE---SEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRK 77
            |:.|||         |..|:.|   .|.....||     |:.:....||..|.|::|.:     :
Human    58 PKPDTF---------SQLEKREVWMPEDTPGGFC-----LDWMTMPASKKSTVKAEIPE-----E 103

  Fly    78 QTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHC 142
            :.|       |.|...:.:..||.:. |....::|.      |:....:|.:|.|...|.:  .|
Human   104 ELD-------QWTIKERFSSSSHWKC-ASLLEWQCG------GQEISLQRVVLTHPNTPSQ--EC 152

  Fly   143 SKT-FTQNSSLKQHLHEHTGERP----FKCTQCSTSFARKSHLQVHLRTHSE----------ERP 192
            .:: .|.:|||  |..:..|.:|    |:|::|...|::.|.|..|.:.|:|          |:.
Human   153 DESGSTMSSSL--HSDQSQGFQPSKNAFECSECGKVFSKSSTLNKHQKIHNEKNANQKIHIKEKR 215

  Fly   193 FECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKT 256
            :||..|.|||..::||..|.|.|...:|::|..|.|:|.:.|.|..|...| .|:.|:|..|.|.
Human   216 YECRECGKAFHQSTHLIHHQRIHTGEKPYECKECGKAFSVSSSLTYHQKIHTGEKPFECNLCGKA 280

  Fly   257 FLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRV 321
            |::|..|..|.|:|.||.||||..|.:.|...:.|..|...|:|::|.||::|...|...:.:..
Human   281 FIRNIHLAHHHRIHTGEKPFKCNICEKAFVCRAHLTKHQNIHSGEKPYKCNECGKAFNQSTSFLQ 345

  Fly   322 HVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEK 386
            |.|:||.|:.::|.||.|:|...|.|.|||::||||:|:||..|.|.|:..:....|...|.|||
Human   346 HQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPYKCNECGKAFRDNSSFARHRKIHTGEK 410

  Fly   387 VPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSK 451
            ..:|..|.|.|:..|.|..|.:.|||:..:.|..|.|:::..|.|..|.|.||.|.|:||..|.|
Human   411 PYRCGLCEKAFRDQSALAQHQRIHTGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKICEK 475

  Fly   452 LFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|.||....:|.|.|||||||||:.|...:.|.::|.:|.|
Human   476 AFIRSTHLTQHQRIHTGEKPYKCNKCGKAFNQTANLIQHQR 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5245NP_650197.1 COG5048 74..478 CDD:227381 147/419 (35%)
C2H2 Zn finger 84..104 CDD:275368 4/19 (21%)
C2H2 Zn finger 112..132 CDD:275368 4/19 (21%)
C2H2 Zn finger 139..159 CDD:275368 6/20 (30%)
C2H2 Zn finger 167..187 CDD:275368 6/19 (32%)
zf-H2C2_2 179..204 CDD:290200 11/34 (32%)
C2H2 Zn finger 195..215 CDD:275368 9/19 (47%)
C2H2 Zn finger 223..243 CDD:275368 7/19 (37%)
C2H2 Zn finger 250..270 CDD:275368 8/19 (42%)
C2H2 Zn finger 278..298 CDD:275368 5/19 (26%)
C2H2 Zn finger 306..326 CDD:275368 5/19 (26%)
C2H2 Zn finger 334..354 CDD:275368 10/19 (53%)
C2H2 Zn finger 362..382 CDD:275368 5/19 (26%)
C2H2 Zn finger 390..410 CDD:275368 7/19 (37%)
C2H2 Zn finger 418..438 CDD:275368 7/19 (37%)
C2H2 Zn finger 446..466 CDD:275368 8/19 (42%)
C2H2 Zn finger 474..492 CDD:275368 5/17 (29%)
ZNF454NP_001171560.1 KRAB 14..73 CDD:214630 7/23 (30%)
KRAB 14..53 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..170 7/26 (27%)
zf-C2H2 178..200 CDD:278523 7/21 (33%)
C2H2 Zn finger 180..200 CDD:275368 6/19 (32%)
COG5048 186..522 CDD:227381 129/331 (39%)
C2H2 Zn finger 218..238 CDD:275368 9/19 (47%)
zf-H2C2_2 230..254 CDD:290200 9/23 (39%)
C2H2 Zn finger 246..266 CDD:275368 7/19 (37%)
zf-H2C2_2 258..283 CDD:290200 9/24 (38%)
C2H2 Zn finger 274..294 CDD:275368 8/19 (42%)
zf-H2C2_2 286..311 CDD:290200 12/24 (50%)
C2H2 Zn finger 302..322 CDD:275368 5/19 (26%)
zf-H2C2_2 314..339 CDD:290200 9/24 (38%)
C2H2 Zn finger 330..350 CDD:275368 5/19 (26%)
zf-H2C2_2 342..365 CDD:290200 9/22 (41%)
C2H2 Zn finger 358..378 CDD:275368 10/19 (53%)
zf-H2C2_2 370..393 CDD:290200 13/22 (59%)
C2H2 Zn finger 386..406 CDD:275368 5/19 (26%)
zf-H2C2_2 398..421 CDD:290200 8/22 (36%)
C2H2 Zn finger 414..434 CDD:275368 7/19 (37%)
zf-H2C2_2 426..450 CDD:290200 8/23 (35%)
C2H2 Zn finger 442..462 CDD:275368 7/19 (37%)
zf-H2C2_2 454..479 CDD:290200 12/24 (50%)
C2H2 Zn finger 470..490 CDD:275368 8/19 (42%)
zf-H2C2_2 482..507 CDD:290200 12/24 (50%)
C2H2 Zn finger 498..518 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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