DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF841

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001356754.1	Gene:	ZNF841 / 284371	HGNCID:	27611	Length:	925	Species:	Homo sapiens

Alignment Length:	408	Identity:	168/408 - (41%)
Similarity:	236/408 - (57%)	Gaps:	2/408 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 QCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEK-RPHKCSHCSKTFTQN 149
            :|.|.|....:|.:|..:|..|:|:.|:...|:|.|.:....|.:.|.: :|::|..|.:.|.||
Human   266 ECGKAFRVSSSLINHQMIHTTEKPYRCNESGKAFHRGSLLTVHQIVHTRGKPYQCDVCGRIFRQN 330

  Fly   150 SSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRT 214
            |.|..|...|||::|:.|.:|..||::.|||.||.|.|:.|:|::|..|.|.|..:|.|..|...
Human   331 SDLVNHRRSHTGDKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNRCGKCFSQSSSLATHQTV 395

  Fly   215 HQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKC 278
            |...:|:||:.|.|:||..|.|..|.:.|| ::.:.|..|.|.|.||..|..|..:|.||.|:||
Human   396 HTGDKPYKCNECGKTFKRNSSLTAHHIIHAGKKPYTCDVCGKVFYQNSQLVRHQIIHTGETPYKC 460

  Fly   279 PHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFK 343
            ..|.:.|.:.|||..|...|.|::|.||::|...|:..|...||.|:||.|:.|||.||.|:|..
Human   461 NECGKVFFQRSRLAGHRRIHTGEKPYKCNECGKVFSQHSHLAVHQRVHTGEKPYKCNECGKAFNW 525

  Fly   344 KSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQ 408
            .|.|..||::||||:|:||..|.|.|....:|.|||..|.|||...|:.|...|...|.|..|.:
Human   526 GSLLTVHQRIHTGEKPYKCNVCGKVFNYGGYLSVHMRCHTGEKPLHCNKCGMVFTYYSCLARHQR 590

  Fly   409 EHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYK 473
            .|||:..::|..|.|.:..|..|.:|.|:||||.||:|:.|.|:|:..:....|.:.||||||||
Human   591 MHTGEKPYKCNVCGKVFIDSGNLSIHRRSHTGEKPFQCNECGKVFSYYSCLARHRKIHTGEKPYK 655

  Fly   474 CSHCSTRYTQKSSLGRHL 491
            |:.|...|||:|||.:||
Human   656 CNDCGKAYTQRSSLTKHL 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	159/393 (40%)
		C2H2 Zn finger	84..104	CDD:275368	5/17 (29%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	10/19 (53%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..492	CDD:275368	10/18 (56%)
ZNF841	NP_001356754.1	KRAB	8..69	CDD:214630
		COG5048	260..636	CDD:227381	148/369 (40%)
		C2H2 Zn finger	265..284	CDD:275368	5/17 (29%)
		C2H2 Zn finger	292..312	CDD:275368	5/19 (26%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		C2H2 Zn finger	348..368	CDD:275368	10/19 (53%)
		C2H2 Zn finger	376..396	CDD:275368	7/19 (37%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		C2H2 Zn finger	432..452	CDD:275368	8/19 (42%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		COG5048	484..886	CDD:227381	86/190 (45%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		C2H2 Zn finger	516..536	CDD:275368	9/19 (47%)
		C2H2 Zn finger	544..564	CDD:275368	8/19 (42%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		C2H2 Zn finger	628..648	CDD:275368	5/19 (26%)
		C2H2 Zn finger	656..676	CDD:275368	10/18 (56%)
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	740..760	CDD:275368
		C2H2 Zn finger	768..788	CDD:275368
		C2H2 Zn finger	796..816	CDD:275368
		C2H2 Zn finger	824..844	CDD:275368
		C2H2 Zn finger	852..872	CDD:275368
		C2H2 Zn finger	880..900	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900