DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF615

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001308252.1	Gene:	ZNF615 / 284370	HGNCID:	24740	Length:	747	Species:	Homo sapiens

Alignment Length:	529	Identity:	191/529 - (36%)
Similarity:	256/529 - (48%)	Gaps:	56/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FEEELIF------ISNSDFEELESEIKIEN--FCS-YGK---------DLEPVK--GVPSKLKTC 65
            |..|:.|      |:.|.|.:.:....|||  .|| .||         |.:.|.  ..|.....|
Human   189 FYTEMKFPAIAKPINKSQFIKQQRTHNIENAHVCSECGKAFLKLSQFIDHQRVHTGEKPHVCSMC 253

  Fly    66 KSKIAKKRPL--RKQTDT----FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTH 124
            ....::|..|  .::|.|    ::||:|.|||.:|..|..|.:.|...:|:.||.|.|:|.::..
Human   254 GKAFSRKSRLMDHQRTHTELKHYECTECDKTFLKKSQLNIHQKTHMGGKPYTCSQCGKAFIKKCR 318

  Fly   125 YKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHS 188
            ...|...|. ::||.||.|.|.|:...||..|...||||:|:.|::|...|..|..|..|.|||:
Human   319 LIYHQRTHTGEKPHGCSVCGKAFSTKFSLTTHQKTHTGEKPYICSECGKGFIEKRRLTAHHRTHT 383

  Fly   189 EERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQ 252
            .|:||.|..|.|.|...:.|..|.:||...:.:.||.|.|.|.::..|..|..|| .|:.:||.:
Human   384 GEKPFICNKCGKGFTLKNSLITHQQTHTGEKLYTCSECGKGFSMKHCLMVHQRTHTGEKPYKCNE 448

  Fly   253 CPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRS 317
            |.|.|.....|..|.|.|.||.|:.|..|.:.|...|.|.:|...|..::|..|:.|...|.::|
Human   449 CGKGFALKSPLIRHQRTHTGEKPYVCTECRKGFTMKSDLIVHQRTHTAEKPYICNDCGKGFTVKS 513

  Fly   318 LYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDH 382
            ...||.|.||.|:.|.|.||.|.|..|..|:.||:.||||:|:.|..|.|.|..::||.||...|
Human   514 RLIVHQRTHTGEKPYVCGECGKGFPAKIRLMGHQRTHTGEKPYICNECGKGFTEKSHLNVHRRTH 578

  Fly   383 IGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCS 447
            .|||...||.|.|.....|.|:.|.:.|||:..:.|..|.|.:|..|||.:|.:|||||.|:||:
Human   579 TGEKPYVCSECGKGLTGKSMLIAHQRTHTGEKPYICNECGKGFTMKSTLSIHQQTHTGEKPYKCN 643

  Fly   448 HCSKLFARSA---EHQE-------------------------HLRTHTGEKPYKCSHCSTRYTQK 484
            .|.|.|.:..   :||.                         |.|.||||||||||.|...:|.|
Human   644 ECDKTFRKKTCLIQHQRFHTGKTSFACTECGKFSLRKNDLITHQRIHTGEKPYKCSDCGKAFTTK 708

  Fly   485 SSLGRHLRR 493
            |.|..|.|:
Human   709 SGLNVHQRK 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	166/439 (38%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	6/19 (32%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	8/47 (17%)
		C2H2 Zn finger	474..492	CDD:275368	8/17 (47%)
ZNF615	NP_001308252.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		COG5048	<100..430	CDD:227381	79/240 (33%)
		C2H2 Zn finger	222..242	CDD:275368	5/19 (26%)
		zf-H2C2_2	238..259	CDD:290200	3/20 (15%)
		C2H2 Zn finger	250..270	CDD:275368	3/19 (16%)
		C2H2 Zn finger	278..298	CDD:275368	9/19 (47%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		COG5048	330..734	CDD:227381	152/388 (39%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	431..454	CDD:290200	9/22 (41%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..482	CDD:290200	9/22 (41%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
		C2H2 Zn finger	502..522	CDD:275368	7/19 (37%)
		C2H2 Zn finger	530..550	CDD:275368	9/19 (47%)
		C2H2 Zn finger	558..578	CDD:275368	8/19 (42%)
		zf-H2C2_2	570..591	CDD:290200	11/20 (55%)
		C2H2 Zn finger	586..606	CDD:275368	7/19 (37%)
		C2H2 Zn finger	614..634	CDD:275368	8/19 (42%)
		zf-H2C2_2	627..649	CDD:290200	12/21 (57%)
		C2H2 Zn finger	642..662	CDD:275368	6/19 (32%)
		C2H2 Zn finger	670..690	CDD:275368	2/19 (11%)
		zf-H2C2_2	682..707	CDD:290200	13/24 (54%)
		C2H2 Zn finger	698..718	CDD:275368	9/20 (45%)
		C2H2 Zn finger	726..746	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810