DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF780A

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_024307222.1	Gene:	ZNF780A / 284323	HGNCID:	27603	Length:	658	Species:	Homo sapiens

Alignment Length:	560	Identity:	179/560 - (31%)
Similarity:	257/560 - (45%)	Gaps:	103/560 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PQEDTFE-----------------EELIFISNSDFEELE-----SEIKI-ENFCSYGKDLEPVKG 57
            |:.||.|                 |...|.::|::.:.|     .|..| :...||.|
Human   107 PENDTSEVNLPKQVIKQISTTLGIEAFYFRNDSEYRQFEGLQGYQEGNINQKMISYEK------- 164

  Fly    58 VPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRR 122
            :|:............:|       ::|.:|.|.|:|..||..|..:|..|:||||..|.|:|...
Human   165 LPTHTPHASLICNTHKP-------YECKECGKYFSRSANLIQHQSIHTGEKPFECKECGKAFRLH 222

  Fly   123 THYKRH-----------------------LLKHEKRPH------KCSHCSKTFTQNSSLKQHLHE 158
            ..:.||                       ||...|..|      :|..|.|:|.::|:|.||...
Human   223 IQFTRHQKFHTGEKPFECNECGKAFSLLTLLNRHKNIHTGEKLFECKECGKSFNRSSNLVQHQSI 287

  Fly   159 HTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKC 223
            |:|.:|::|.:|...|.|.:||..|.:.||.|:||.|..|..||:.:..|.||.:.|...:||:|
Human   288 HSGVKPYECKECGKGFNRGAHLIQHQKIHSNEKPFVCKECGMAFRYHYQLIEHCQIHTGEKPFEC 352

  Fly   224 SHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFAR 287
            ..|.|:|.|.:.|.:|...| .|:.|:|.:|.|.|...:.|..|..:|.||.||:|..|.::|.|
Human   353 KECGKAFTLLTKLVRHQKIHTGEKPFECRECGKAFSLLNQLNRHKNIHTGEKPFECKECGKSFNR 417

  Fly   288 NSRLQLHLLEHAGKEPLKCSQCSATF------------------------AMRSLYRV----HVR 324
            :|.|..|...|||.:|.:|.:|...|                        .|...|..    |.|
Human   418 SSNLVQHQSIHAGIKPYECKECGKGFNRGAHLIQHQKIHSNEKPFVCRECEMAFRYHCQLIEHSR 482

  Fly   325 LHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPK 389
            :||.::.::|.:|.|:|.:.|.||:||.:||||:|::|..|.|.|:....|..|...|.|||..:
Human   483 IHTGDKPFECQDCGKAFNRGSSLVQHQSIHTGEKPYECKECGKAFRLYLQLSQHQKTHTGEKPFE 547

  Fly   390 CSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHL----RTHTGELPFKCSHCS 450
            |..|.|.|:..|.|..|...||||..|||..|.|::    .|||||    :.||||.||:|..|.
Human   548 CKECGKFFRRGSNLNQHRSIHTGKKPFECKECGKAF----RLHMHLIRHQKLHTGEKPFECKECG 608

  Fly   451 KLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            |.|....:...|.:.||||||::|..|...::..:.|.||
Human   609 KAFRLHMQLIRHQKLHTGEKPFECKECGKVFSLPTQLNRH 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/465 (35%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	8/42 (19%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/47 (15%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/23 (35%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF780A	XP_024307222.1	KRAB	22..83	CDD:214630
		C2H2 Zn finger	184..204	CDD:275368	8/19 (42%)
		zf-H2C2_2	196..220	CDD:316026	11/23 (48%)
		C2H2 Zn finger	212..232	CDD:275368	6/19 (32%)
		COG5048	236..612	CDD:227381	132/379 (35%)
		C2H2 Zn finger	240..260	CDD:275368	3/19 (16%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	3/19 (16%)
		C2H2 Zn finger	464..484	CDD:275368	4/19 (21%)
		C2H2 Zn finger	492..512	CDD:275368	9/19 (47%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	548..568	CDD:275368	7/19 (37%)
		C2H2 Zn finger	576..596	CDD:275368	8/23 (35%)
		C2H2 Zn finger	604..624	CDD:275368	5/19 (26%)
		C2H2 Zn finger	632..652	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900