Protein Alignment CG5245 and ZNF311

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: XP_005249076.1
• Gene: ZNF311 / 282890
• HGNCID: 13847
• Length: 699
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 170/498 - (34%)
• Similarity: 248/498 - (49%)
• Gaps: 40/498 - (8%)

  Fly    17 QEDTFE---------EELIFISNSDFEELE---SEIKIENFCSYG---KDLEPVKGVPSKLKTCK 66
            |::.||         ..|:.:.:.|.:..|   .::|:||.....   |..|..:|  |:..|||
Human   187 QQEIFENGEAYWMKFNSLLKVDSRDPKVREVCVQDVKLENQWETSIREKLREEKEG--SEEVTCK 249

  Fly    67 SKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLK 131
            ....:|...:......|.:||.|....:       :||      ||:.|.|:|.    :...|:.
Human   250 KGKNQKVLSKNLNPNSKHSQCNKVLIAQ-------KLH------ECARCGKNFS----WHSDLIL 297

  Fly   132 HE-----KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEER 191
            ||     ::||.|:.|.|.|...:.|..|...||||:||.||||..:|..:|.|..|.:|||.|:
Human   298 HEQIHSGEKPHVCNECGKAFKTRNQLSMHRIIHTGEKPFNCTQCGKAFNSRSALCRHKKTHSGEK 362

  Fly   192 PFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPK 255
            |.||..|.||||..:.|..|...|...:|:||:.|.|:|:.:..|..|...| .|:.::|.:|.|
Human   363 PHECRDCGKAFKTRNRLCMHQLIHTGEKPYKCNCCGKAFQFKHSLTIHGRIHTGEKPYECEECGK 427

  Fly   256 TFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYR 320
            .|..:..|..|:|:|.||.|::|..|...|:|:|.|..|...|..::...|.||...|::::...
Human   428 AFSGSSDLTKHIRIHTGERPYECSKCGRAFSRSSDLSKHKRIHTREKHYGCPQCGKDFSIKAELT 492

  Fly   321 VHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGE 385
            .|.|:||.|::|:|.||.|:|........|::.||||:|::|..|.|.|:.:..|.:|...|.||
Human   493 KHRRIHTEEKRYRCEECGKAFRHNCKRRAHEREHTGEKPYQCRDCGKTFQDKHCLTIHQRIHTGE 557

  Fly   386 KVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCS 450
            |..||..|.|.|...|.|..|.:.|||:...:|..|..::..||.|..|.|.||||.|:.||.|.
Human   558 KPYKCLECGKAFSGKSNLTNHRRIHTGEKPHKCEVCGMAFHHSSVLRQHKRIHTGEKPYTCSECG 622

  Fly   451 KLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRR 493
            ..|.:.:....|.|.|||||||:|..|...:...|:|..|.:|
Human   623 TSFRQGSALIGHKRVHTGEKPYECEECGKAFRVSSNLTGHKKR 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	148/409 (36%)
		C2H2 Zn finger	84..104	CDD:275368	3/19 (16%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF311	XP_005249076.1	KRAB	97..157	CDD:214630
		C2H2 Zn finger	282..302	CDD:275368	7/23 (30%)
		COG5048	306..>633	CDD:227381	124/326 (38%)
		C2H2 Zn finger	310..330	CDD:275368	6/19 (32%)
		C2H2 Zn finger	338..358	CDD:275368	8/19 (42%)
		C2H2 Zn finger	366..386	CDD:275368	8/19 (42%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	422..442	CDD:275368	7/19 (37%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		C2H2 Zn finger	534..554	CDD:275368	6/19 (32%)
		C2H2 Zn finger	562..582	CDD:275368	7/19 (37%)
		C2H2 Zn finger	590..610	CDD:275368	7/19 (37%)
		C2H2 Zn finger	618..638	CDD:275368	6/19 (32%)
		zf-H2C2_2	634..653	CDD:463886	11/18 (61%)
		C2H2 Zn finger	646..664	CDD:275368	5/17 (29%)