DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5245 and ZNF473

DIOPT Version :9

Sequence 1:NP_650197.1 Gene:CG5245 / 41530 FlyBaseID:FBgn0038047 Length:501 Species:Drosophila melanogaster
Sequence 2:NP_001006657.1 Gene:ZNF473 / 25888 HGNCID:23239 Length:871 Species:Homo sapiens


Alignment Length:546 Identity:180/546 - (32%)
Similarity:251/546 - (45%) Gaps:117/546 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 KTCKSKIAKKRP---------LRKQTD--TFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCS 116
            |.|||:.:...|         .:..||  ::.|.:|.|.|||..:|..|.::|..:| :|||.|.
Human   290 KPCKSQDSDHPPSHDTQPGEHQKTHTDSKSYNCNECGKAFTRIFHLTRHQKIHTRKR-YECSKCQ 353

  Fly   117 KSFGRRTHYKRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHL 180
            .:|..|.|..:|...| .|...:|..|.|.|..:|.|.:|...|.||.|:||.:...||...|.|
Human   354 ATFNLRKHLIQHQKTHAAKTTSECQECGKIFRHSSLLIEHQALHAGEEPYKCNERGKSFRHNSTL 418

  Fly   181 QVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-A 244
            ::|.|.||.|:|::|:.|.|||..::||.||.|.|...||.||..|.:||...|.|.:|...| |
Human   419 KIHQRVHSGEKPYKCSECGKAFHRHTHLNEHRRIHTGYRPHKCQECVRSFSRPSHLMRHQAIHTA 483

  Fly   245 ERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHA---------- 299
            |:.:.|.:|.:||..|:.|..|.::|..:.|::|..|.|.|...|.|:.|...||          
Human   484 EKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICGSTLKCHESVHAREKQGFFVSG 548

  Fly   300 --------------------------------------GKEPLKCSQCSATF--AMRSLY--RVH 322
                                                  |.:|.:|.||...|  :.|.::  |:|
Human   549 KILDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAFGQSTRLIHHQRIH 613

  Fly   323 VRL-----------------------HTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTH 364
            .|:                       ||:|..:||.||.|:|...:||.:||.:|.||.||||:.
Human   614 SRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSK 678

  Fly   365 CFKDFKC--------RTHLR--------------------VHMLDHIGEKVPKCSYCSKEFKLSS 401
            |.:.|..        |||.|                    .|...|.|||...|.||.|.|.||:
Human   679 CDRVFTQRNYLVQHERTHARKKPLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSA 743

  Fly   402 QLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTH 466
            :|:.|.:.|||:..:.|..|.|::|.||.|.:|.|.||||.|::|..|.|.||:.|...:|.|.|
Human   744 ELVRHQRIHTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIH 808

  Fly   467 TGEKPYKCSHCSTRYTQKSSLGRHLR 492
            ||||||.|:.|...:...:.|.:|||
Human   809 TGEKPYSCNVCGKAFVLSAHLNQHLR 834

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5245NP_650197.1 COG5048 74..478 CDD:227381 171/519 (33%)
C2H2 Zn finger 84..104 CDD:275368 8/19 (42%)
C2H2 Zn finger 112..132 CDD:275368 7/19 (37%)
C2H2 Zn finger 139..159 CDD:275368 7/19 (37%)
C2H2 Zn finger 167..187 CDD:275368 7/19 (37%)
zf-H2C2_2 179..204 CDD:290200 12/24 (50%)
C2H2 Zn finger 195..215 CDD:275368 10/19 (53%)
C2H2 Zn finger 223..243 CDD:275368 7/19 (37%)
C2H2 Zn finger 250..270 CDD:275368 7/19 (37%)
C2H2 Zn finger 278..298 CDD:275368 7/19 (37%)
C2H2 Zn finger 306..326 CDD:275368 8/46 (17%)
C2H2 Zn finger 334..354 CDD:275368 9/19 (47%)
C2H2 Zn finger 362..382 CDD:275368 8/47 (17%)
C2H2 Zn finger 390..410 CDD:275368 9/19 (47%)
C2H2 Zn finger 418..438 CDD:275368 9/19 (47%)
C2H2 Zn finger 446..466 CDD:275368 8/19 (42%)
C2H2 Zn finger 474..492 CDD:275368 4/17 (24%)
ZNF473NP_001006657.1 KRAB_A-box 6..45 CDD:143639
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 47..81
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..164
COG5048 207..614 CDD:227381 100/324 (31%)
C2H2 Zn finger 211..231 CDD:275368
C2H2 Zn finger 239..259 CDD:275368
C2H2 Zn finger 267..286 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 290..318 7/27 (26%)
Interaction with SLBP/pre-mRNA complex 312..552 87/240 (36%)
C2H2 Zn finger 322..342 CDD:275368 8/19 (42%)
C2H2 Zn finger 349..369 CDD:275368 7/19 (37%)
C2H2 Zn finger 377..397 CDD:275368 7/19 (37%)
C2H2 Zn finger 405..425 CDD:275368 7/19 (37%)
C2H2 Zn finger 433..453 CDD:275368 10/19 (53%)
COG5048 457..860 CDD:227381 119/378 (31%)
C2H2 Zn finger 461..481 CDD:275368 7/19 (37%)
C2H2 Zn finger 489..509 CDD:275368 7/19 (37%)
C2H2 Zn finger 517..537 CDD:275368 7/19 (37%)
C2H2 Zn finger 564..584 CDD:275368 0/19 (0%)
C2H2 Zn finger 593..613 CDD:275368 6/19 (32%)
C2H2 Zn finger 648..668 CDD:275368 9/19 (47%)
C2H2 Zn finger 676..696 CDD:275368 4/19 (21%)
C2H2 Zn finger 704..724 CDD:275368 1/19 (5%)
C2H2 Zn finger 732..752 CDD:275368 9/19 (47%)
C2H2 Zn finger 760..780 CDD:275368 9/19 (47%)
C2H2 Zn finger 788..808 CDD:275368 8/19 (42%)
C2H2 Zn finger 816..836 CDD:275368 6/19 (32%)
C2H2 Zn finger 844..864 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100020
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.