DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and Zfp937

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001135883.1	Gene:	Zfp937 / 245174	MGIID:	3644476	Length:	503	Species:	Mus musculus

Alignment Length:	486	Identity:	184/486 - (37%)
Similarity:	259/486 - (53%)	Gaps:	28/486 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EEELIFISNSDFEELESEIKIE---NFCSYG---KDLEPVKGVPSKLKTCKSKIAKKRPLRKQTD 80
            :||...:..|. :.|..::.:|   |..:.|   :|..|.:...|..:..:   .:|..:.::..
Mouse    15 QEEWALLDPSQ-KNLYRDVMLETYRNLAAIGYSWEDHNPEEHFQSSRRHGR---LEKSHIEEKPS 75

  Fly    81 TFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSF----GRRTHYKRHLLKHEKRPHKCSH 141
            .|  |||.|....:.:.:.|.::|..|:|:||..|.|||    |.:.|.:.|   |.::.::|:.
Mouse    76 EF--TQCGKVIAYQSHPQGHQQIHTGEKPYECEQCGKSFVCQSGLQQHKRTH---HGEKSYECNQ 135

  Fly   142 CSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNS 206
            |.|.|.....|:.|...||||:|::|.||..:||.::.|..|.||||.|:.:.|..|.|||...|
Mouse   136 CDKAFALLCHLRGHQRIHTGEKPYECNQCDKAFACQTSLLYHKRTHSGEKLYVCNECGKAFVLQS 200

  Fly   207 HLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-----AERSFKCTQCPKTFLQNDSLQIH 266
            :||.|.|||...:||.|..|.|:|...|    |||||     .|:.|.|.||.|.|.||..|..|
Mouse   201 YLQIHKRTHTGEKPFGCDQCDKAFAQNS----HLLTHKRTHTGEKPFGCDQCDKAFAQNSHLLTH 261

  Fly   267 LRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQ 331
            .|.|.||.||.|..|.:.||:||.|..|...|.|::|.:|.||...|..:|..:.|.|.||.|:.
Mouse   262 KRTHTGEKPFGCDQCDKAFAQNSHLLTHKRTHTGEKPYECKQCGKAFGFQSGLQKHKRTHTGEKP 326

  Fly   332 YKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKE 396
            |:|.:|.|:|..:|.|.:|::.||||:|::|..|.|.|.|:..|..|...|.|||..:||.|.|.
Mouse   327 YECKQCGKAFGYQSGLQKHKRTHTGEKPYECNQCDKAFACQASLLNHKRSHTGEKPYECSECGKA 391

  Fly   397 FKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQE 461
            |.|.|.|.:|.:.|||:..|||..|.|::..::.|..|.|.|||:..:.|..|.|.||..:..|.
Mouse   392 FVLHSYLQIHKRTHTGEKPFECDQCDKAFARNTLLLKHKRIHTGQKAYGCKQCGKAFANHSNLQV 456

  Fly   462 HLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            |.|||||||||:|..|...:..:|.|..|.|
Mouse   457 HKRTHTGEKPYECKQCGKAFGCQSGLQYHKR 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	168/412 (41%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	8/23 (35%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	10/19 (53%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp937	NP_001135883.1	KRAB	4..57	CDD:214630	9/42 (21%)
		KRAB	4..43	CDD:279668	6/28 (21%)
		C2H2 Zn finger	78..97	CDD:275368	5/18 (28%)
		COG5048	86..486	CDD:227381	166/406 (41%)
		zf-H2C2_2	93..114	CDD:290200	10/20 (50%)
		C2H2 Zn finger	105..125	CDD:275368	7/19 (37%)
		zf-H2C2_2	118..141	CDD:290200	6/25 (24%)
		C2H2 Zn finger	133..153	CDD:275368	6/19 (32%)
		zf-H2C2_2	145..170	CDD:290200	11/24 (46%)
		C2H2 Zn finger	161..181	CDD:275368	8/19 (42%)
		C2H2 Zn finger	189..209	CDD:275368	10/19 (53%)
		C2H2 Zn finger	217..237	CDD:275368	10/23 (43%)
		C2H2 Zn finger	245..265	CDD:275368	10/19 (53%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	285..308	CDD:290200	8/22 (36%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	314..338	CDD:290200	10/23 (43%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	11/23 (48%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	369..393	CDD:290200	10/23 (43%)
		C2H2 Zn finger	385..405	CDD:275368	9/19 (47%)
		zf-H2C2_2	397..422	CDD:290200	10/24 (42%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-H2C2_2	453..476	CDD:290200	13/22 (59%)
		C2H2 Zn finger	469..488	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900