DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp473

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001276765.1	Gene:	Zfp473 / 243963	MGIID:	2442697	Length:	892	Species:	Mus musculus

Alignment Length:	531	Identity:	165/531 - (31%)
Similarity:	244/531 - (45%)	Gaps:	105/531 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 KSKIAKKRPLRKQ-TDT----FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHY 125
            :..:...:|||.| |.|    |:|.:|.:||:...:|..|.|.|| :|.::|:.|...|....|.
Mouse   356 RPSVLHPKPLRHQKTPTNAKCFRCKKCGETFSGAFHLAKHQRAHA-QRLYKCASCPAVFNLSKHC 419

  Fly   126 KRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSE 189
            .:|...| .....:|..|.|:|...|||.:|...|.||:|:||.:|..:|...|.|::|.|.||.
Mouse   420 FQHRKSHFPSAACECQGCRKSFNWRSSLIKHQAIHKGEKPYKCDECGKAFNHSSTLKIHQRIHSG 484

  Fly   190 ERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQC 253
            ::|.:|:.|.|||...:.|.||.|.|...||.:|..|:::|...|.|.:|.|.|| ||.|.|.:|
Mouse   485 QKPHKCSECGKAFCRRTDLTEHQRVHSGFRPHQCPVCARTFNRPSHLVRHRLRHAEERHFGCAKC 549

  Fly   254 PKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEH-------------------- 298
            .:||:..:.|:.|.::|..|..::|..|.|.|...|.|..||..|
Mouse   550 KETFIYKEQLERHNKIHTIEGLYECKQCGEHFICRSTLNCHLSIHIRENTSEKVVGQNSQHTEKC 614

  Fly   299 ---------------------------------------------------AGKEPLKCSQ---- 308
                                                               ||.:|.:|::
Mouse   615 FKNTKCRKAPNHSRYLGQHEKIHAQVTSGECDPCGETYDQSVQPICHQSICAGVKPSECAEPEKC 679

  Fly   309 -------------------C---SATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQ 351
                               |   :..|..|:....|..:|..|:.:||.||.::|.:.::|::||
Mouse   680 TRNTSASEHHPSQREPSFKCDIYNRAFKQRAHLSKHQLIHITEKPFKCNECDRAFKQSNYLIQHQ 744

  Fly   352 QVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQF 416
            :.||.|:.|:|:.|.|.|..|:.|..|...|.|||..||..|.|.|...:||:.|.:.|||:..:
Mouse   745 KTHTAEKHFECSECGKTFHQRSCLSKHQKIHSGEKPFKCGDCGKAFISGAQLIRHQRIHTGEKPY 809

  Fly   417 ECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRY 481
            .|..|.|:::.||.|.:|||.||||.|:.|..|.|.||:.|..::|.|.|||||||.|..|...:
Mouse   810 VCQECGKTFSQSSCLTLHLRIHTGEKPYTCGTCGKAFAQRANQRKHERIHTGEKPYACGLCGKAF 874

  Fly   482 TQKSSLGRHLR 492
            ..::.|.:|.|
Mouse   875 GLRTHLQQHQR 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/507 (32%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	5/45 (11%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	4/17 (24%)
Zfp473	NP_001276765.1	KRAB_A-box	23..63	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..97
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..203
		C2H2 Zn finger	211..231	CDD:275368
		C2H2 Zn finger	267..287	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..370		4/13 (31%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		zf-H2C2_2	446..471	CDD:372612	11/24 (46%)
		C2H2 Zn finger	462..482	CDD:275368	7/19 (37%)
		COG5048	485..888	CDD:227381	120/401 (30%)
		C2H2 Zn finger	490..510	CDD:275368	9/19 (47%)
		C2H2 Zn finger	518..538	CDD:275368	7/19 (37%)
		C2H2 Zn finger	546..566	CDD:275368	6/19 (32%)
		C2H2 Zn finger	574..594	CDD:275368	8/19 (42%)
		C2H2 Zn finger	617..637	CDD:275368	0/19 (0%)
		C2H2 Zn finger	645..665	CDD:275368	0/19 (0%)
		C2H2 Zn finger	699..719	CDD:275368	4/19 (21%)
		C2H2 Zn finger	727..747	CDD:275368	7/19 (37%)
		C2H2 Zn finger	755..775	CDD:275368	7/19 (37%)
		C2H2 Zn finger	783..803	CDD:275368	7/19 (37%)
		C2H2 Zn finger	811..831	CDD:275368	9/19 (47%)
		C2H2 Zn finger	839..859	CDD:275368	8/19 (42%)
		C2H2 Zn finger	867..887	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900