Protein Alignment CG5245 and Zfp53

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_038871.1
• Gene: Zfp53 / 24132
• MGIID: 99200
• Length: 652
• Species: Mus musculus
• Alignment Length: 503
• Identity: 192/503 - (38%)
• Similarity: 277/503 - (55%)
• Gaps: 28/503 - (5%)

  Fly     1 MDLANVDQRP---VKDEPPQEDTFEEELIFISN-SDFEELESEIKIENFCSYGKDLEPVKGVPSK 61
            :||.|.|:..   ..:|..:.:..|:.|...|| ::.:.|.:..|:::...|..|...|..
Mouse   153 VDLLNQDRHKSTHTGEELCKSEDCEKSLSLSSNLTENQRLYAANKLQSQGEYDDDFSSVYS---- 213

  Fly    62 LKTCKSKIAKKRPLRKQT----DT-FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGR 121
                         |.:||    || .:|.:|:|.|:...:|..|.|:|..::|::||.|.|||.:
Mouse   214 -------------LMQQTIYIGDTPHQCEKCRKCFSTASSLTVHKRIHTGKKPYKCSVCGKSFTQ 265

  Fly   122 RTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLR 185
            .|:.|.|...|. ::|:||..|.|:|.|.|:||.|...||||||:||.:|..|||..|..:.|.:
Mouse   266 CTNLKTHQRLHTGEKPYKCKECGKSFPQLSALKSHQKIHTGERPYKCKECDKSFAHCSSFRRHQK 330

  Fly   186 THSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFK 249
            ||..|....|..|.|.....|||:.|.|.|...:|:||:.|.:||...:..::|..||: ::.:|
Mouse   331 THRAEEHCSCPECGKVLHQLSHLRSHYRLHTGEKPYKCNECDRSFTYYASYRRHQKTHSLDKFYK 395

  Fly   250 CTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFA 314
            |.:|.|:||:...|:.|.|:|.||.|:||..|.::|..||.|:.||..|.|::|.||.:|..:|.
Mouse   396 CKECGKSFLELSHLKRHYRIHTGEKPYKCEVCDKSFTVNSTLKTHLKIHTGEKPFKCRECDKSFT 460

  Fly   315 MRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHM 379
            ..|..|.|..:||.|:.|:|.||.|||.:.|.|..||::||||:|:||..|.|.|..|::|.:|.
Mouse   461 KCSHLRRHQSVHTGEKPYRCKECDKSFTECSTLRAHQKIHTGEKPYKCRECDKSFIQRSNLIIHQ 525

  Fly   380 LDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPF 444
            ..|.||:...|..|.|.|...|.|.:|.:.|||:..::|..|:||:|..|.|..|.|.||||.|:
Mouse   526 RVHTGERPYICKECGKSFTKCSTLQIHQKIHTGEKPYKCMECNKSFTQDSHLRTHQRVHTGERPY 590

  Fly   445 KCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|..|.|.|.|.:..:.|.:.|||||||||..|...:.|.|:|.||.|
Mouse   591 ICKECGKSFTRCSYLRAHQKIHTGEKPYKCKDCDISFIQISNLRRHQR 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	171/410 (42%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	9/19 (47%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
Zfp53	NP_038871.1	KRAB	53..93	CDD:460171
		COG5048	223..627	CDD:227381	169/403 (42%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		C2H2 Zn finger	256..276	CDD:275368	9/19 (47%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	370..388	CDD:275368	4/17 (24%)
		C2H2 Zn finger	396..416	CDD:275368	8/19 (42%)
		C2H2 Zn finger	424..444	CDD:275368	8/19 (42%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	10/19 (53%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	536..556	CDD:275368	7/19 (37%)
		C2H2 Zn finger	564..584	CDD:275368	9/19 (47%)
		C2H2 Zn finger	592..612	CDD:275368	6/19 (32%)
		C2H2 Zn finger	620..640	CDD:275368	8/19 (42%)