DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp58

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001007576.1	Gene:	Zfp58 / 238693	MGIID:	99205	Length:	489	Species:	Mus musculus

Alignment Length:	410	Identity:	159/410 - (38%)
Similarity:	214/410 - (52%)	Gaps:	6/410 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTF 146
            ||....|.|..|..|..|.|:...|:.|:|..|.|:|..|::...|...|. ::|:||..|.|.|
Mouse    79 KCKDFSKAFFCKSLLTQHQRIRTGEKAFKCEECGKAFNNRSNLSEHKRIHTGEKPYKCEECGKAF 143

  Fly   147 TQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEH 211
            ...|.|..|...||||:|:||.:|..:|...|:|..|.|.|:.|:|::|..|.|||...|....|
Mouse   144 RIRSKLSTHQRVHTGEKPYKCEECGKAFNSHSNLSEHKRIHTGEKPYKCEECGKAFSTRSTYYRH 208

  Fly   212 LRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDP 275
            .:.|...:|:||..|:|.|...|:|:.|...| ||:|:||.:|.|.|.....|:.|..:|:.|.|
Mouse   209 QKNHTGKKPYKCEECAKEFSYPSLLKVHQRIHSAEKSYKCEECGKPFYCPLLLKKHQIIHSAEKP 273

  Fly   276 FKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKS 340
            :||..|.:.|...|.|:.|...||||:|.||..|...|...:..:.|.|:|:.|..|||.||.|.
Mouse   274 YKCAECGKAFHYPSLLKRHQRIHAGKKPCKCKDCDRAFYSSAFLKRHQRIHSEENSYKCGECGKR 338

  Fly   341 FFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLV 405
            |....||..||:.|:||:|:||..|.|.|...::|..|.|.|.|||..||..|.|.|..:..|..
Mouse   339 FCSFPHLQYHQRFHSGEKPYKCEQCGKTFSTLSYLPWHKLRHSGEKSYKCEKCGKMFYSTLDLKK 403

  Fly   406 HLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEK 470
            |.:.|    :::|..|...:...:.|..|.|.||||.|..|..|.|.|:|.....:|...|||||
Mouse   404 HQKIH----EYKCGECHYGFPNYAALTAHQRVHTGEKPHVCEQCGKDFSRIDSLNQHQLVHTGEK 464

  Fly   471 PYKCSHCSTRYTQKSSLGRH 490
            ||||..|...:.:.|||.||
Mouse   465 PYKCEKCGKCFYRSSSLKRH 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	153/396 (39%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	5/19 (26%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
Zfp58	NP_001007576.1	KRAB	2..61	CDD:214630
		KRAB	2..41	CDD:279668
		C2H2 Zn finger	80..100	CDD:275368	7/19 (37%)
		COG5048	106..489	CDD:227381	150/383 (39%)
		C2H2 Zn finger	108..128	CDD:275368	6/19 (32%)
		zf-H2C2_2	120..143	CDD:290200	7/22 (32%)
		C2H2 Zn finger	136..156	CDD:275368	7/19 (37%)
		zf-H2C2_2	149..173	CDD:290200	11/23 (48%)
		C2H2 Zn finger	164..184	CDD:275368	7/19 (37%)
		zf-H2C2_2	176..201	CDD:290200	11/24 (46%)
		C2H2 Zn finger	192..212	CDD:275368	7/19 (37%)
		C2H2 Zn finger	220..240	CDD:275368	7/19 (37%)
		C2H2 Zn finger	248..268	CDD:275368	6/19 (32%)
		C2H2 Zn finger	276..296	CDD:275368	6/19 (32%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		C2H2 Zn finger	332..352	CDD:275368	9/19 (47%)
		zf-H2C2_2	344..369	CDD:290200	13/24 (54%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	5/19 (26%)
		zf-H2C2_2	424..449	CDD:290200	12/24 (50%)
		C2H2 Zn finger	440..460	CDD:275368	6/19 (32%)
		C2H2 Zn finger	468..488	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100