DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp114

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001025104.2	Gene:	Zfp114 / 232966	MGIID:	3037815	Length:	585	Species:	Mus musculus

Alignment Length:	511	Identity:	165/511 - (32%)
Similarity:	237/511 - (46%)	Gaps:	71/511 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DQRPVKDEP---PQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSK 68
            :|.|...|.   |:..|.....| |.|.:|....::      .|:||.....|..|.  |.|...
Mouse   114 EQLPQASEDASCPESPTNSHSSI-IENQEFLSGRAQ------SSWGKTHLSKKQKPQ--KQCPKT 169

  Fly    69 IAKKRP--LRKQTDTFKCT-----------------QCQKT-FTRKENLESHLRLHAEERPFECS 113
            :.|..|  |....||..|.                 .|.|. |....:.:.|  ::.|.|.::||
Mouse   170 LVKTEPRQLLPGVDTLSCISHHNNALHKRDKAHSSGDCGKVIFPVSPSTQHH--VYIERRVYQCS 232

  Fly   114 HCSKSFGRRTHYKRH--LLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFAR 176
            ...::...|.:::.|  :|..||.|.:.:|      :::.::|.:  |.|::.:...:|.|.|::
Mouse   233 KGQEALTDRPNHELHQPVLVGEKSPVRSTH------EDTPIQQSV--HPGKKQYSRHKCGTGFSK 289

  Fly   177 KSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLL 241
            .:|||.:.|..:.::|..|..|.|.|...|.|..|.|.|.|.:|.||..|.|.|.        .|
Mouse   290 NAHLQTNQRVQTGKKPSHCDSCGKGFSRTSDLNIHCRVHTEEKPHKCEVCGKGFT--------KL 346

  Fly   242 THAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKC 306
            :|                   ||.|.|:|.||.|:||..|.:.|:.:|.|..|...|..::|.||
Mouse   347 SH-------------------LQAHERIHTGEKPYKCGDCGKRFSCSSNLHTHQRVHTEEKPYKC 392

  Fly   307 SQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKC 371
            .:|...|::......|.|:||.|:.|||.||.|.|...|....||:|||||:||.|:.|.|.|..
Mouse   393 DECGKRFSLSFNLHSHQRVHTGEKPYKCEECGKGFTSASSFQSHQRVHTGEKPFVCSVCGKGFSR 457

  Fly   372 RTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLR 436
            .::|:.|...|.|||..:|..|.|.|...|.||||...|||:..|:|..|.|.:|.|:.|.:|.|
Mouse   458 TSYLQTHQRVHTGEKPYQCDSCGKAFSQRSHLLVHQIIHTGEKPFKCEECGKEFTQSTGLSIHQR 522

  Fly   437 THTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .||||.|:.|..|.|.|::::..|.|.|.||.||||.|..|...::|:|.|..|.|
Mouse   523 VHTGEKPYTCQQCGKGFSQASHFQRHQRVHTKEKPYICGICCKGFSQRSHLVYHQR 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	142/425 (33%)
		C2H2 Zn finger	84..104	CDD:275368	5/37 (14%)
		C2H2 Zn finger	112..132	CDD:275368	5/21 (24%)
		C2H2 Zn finger	139..159	CDD:275368	2/19 (11%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	9/24 (38%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	4/19 (21%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
Zfp114	NP_001025104.2	KRAB	8..48	CDD:366587
		C2H2 Zn finger	281..300	CDD:275368	7/18 (39%)
		C2H2 Zn finger	308..328	CDD:275368	8/19 (42%)
		zf-H2C2_2	320..345	CDD:372612	11/32 (34%)
		C2H2 Zn finger	336..356	CDD:275368	10/46 (22%)
		COG5048	<344..585	CDD:227381	101/262 (39%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..496	CDD:275368	9/19 (47%)
		C2H2 Zn finger	504..524	CDD:275368	8/19 (42%)
		C2H2 Zn finger	532..552	CDD:275368	7/19 (37%)
		C2H2 Zn finger	560..580	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900