Protein Alignment CG5245 and Zfp418

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_666291.2
• Gene: Zfp418 / 232854
• MGIID: 2444763
• Length: 652
• Species: Mus musculus
• Alignment Length: 489
• Identity: 172/489 - (35%)
• Similarity: 252/489 - (51%)
• Gaps: 37/489 - (7%)

  Fly    43 ENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEE 107
            |.|.:....|:| |.:|...|  :::|..::....:.:..|..:..|:.:.:..|..:.||.:.:
Mouse   165 EKFPAVWNLLQP-KAIPKGEK--QNQIKCRKAFHSEKNNSKSDKYNKSSSPQHRLHEYPRLCSGK 226

  Fly   108 RPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCST 172
            ..||.:.|.:...:.:.......:.|.||:.|..|.|.|.|.::|:.|...||||:|::|.:|..
Mouse   227 EGFESNSCEQDLNKYSIAPSQTDQTENRPYGCHDCGKWFGQKATLRIHQRRHTGEKPYRCGECGK 291

  Fly   173 SFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQ 237
            ||.:.|:|..|.|.||.||||||..|.|||..:|.|..|.|||....|::|..|.:.|:....|.
Mouse   292 SFCQSSNLSEHCRVHSGERPFECLECGKAFGCHSSLLRHQRTHTGEWPYECGDCGRLFRQIVSLI 356

  Fly   238 KHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGK 301
            .|..|| .|:.::|.||.|:|....:|.:|.|||.||.|:.|..|.::|::::.|..|...|.|:
Mouse   357 THQRTHTTEKPYECGQCEKSFSHKATLTVHQRVHTGEKPYHCEACGKSFSQSANLIKHSKIHTGE 421

  Fly   302 EPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFK----------------------- 343
            :|.||.:|...|..|:....|.|.||.||.|:|.||.| |||
Mouse   422 KPYKCGECGLCFRQRATLMKHQRTHTSERPYECRECGK-FFKQYFYLIEHSRIHTTTEFYECGQC 485

  Fly   344 -KSH-----LVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQ 402
             ||:     |:.||:|||||.|:||..|.|.|:.::.|..|...|.||:..:|:.|.|.|:.|..
Mouse   486 GKSYTQNATLIRHQRVHTGESPYKCKECGKAFEYKSRLNRHQRTHTGERPYECAKCGKFFRESYN 550

  Fly   403 LLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHT 467
            |..|.:.||....:.|..|.|.::..:.|..|.|.||||.|:.|..|.|.|:|:....:|.|.||
Mouse   551 LAEHQKIHTKAKPYNCDQCGKCFSRRADLVKHQRVHTGERPYTCGECGKTFSRTTNLVQHRRIHT 615

  Fly   468 GEKPYKCSHCSTRYTQKSSLGRH-LRRTLCGTKS 500
            ||:||:|..|...::|.|:|.|| |..|  |.||
Mouse   616 GERPYECDQCGKSFSQVSTLTRHQLLHT--GEKS 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	153/433 (35%)
		C2H2 Zn finger	84..104	CDD:275368	3/19 (16%)
		C2H2 Zn finger	112..132	CDD:275368	1/19 (5%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	12/48 (25%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	7/18 (39%)
Zfp418	NP_666291.2	KRAB	24..64	CDD:460171
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		COG5048	282..639	CDD:227381	136/357 (38%)
		C2H2 Zn finger	286..306	CDD:275368	8/19 (42%)
		C2H2 Zn finger	314..334	CDD:275368	9/19 (47%)
		C2H2 Zn finger	342..362	CDD:275368	5/19 (26%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
		C2H2 Zn finger	398..418	CDD:275368	5/19 (26%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	7/20 (35%)
		C2H2 Zn finger	482..502	CDD:275368	5/19 (26%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
		C2H2 Zn finger	566..586	CDD:275368	6/19 (32%)
		C2H2 Zn finger	594..614	CDD:275368	7/19 (37%)
		C2H2 Zn finger	622..642	CDD:275368	8/19 (42%)