Protein Alignment CG5245 and Zfp12

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001276518.1
• Gene: Zfp12 / 231866
• MGIID: 99157
• Length: 686
• Species: Mus musculus
• Alignment Length: 500
• Identity: 182/500 - (36%)
• Similarity: 270/500 - (54%)
• Gaps: 29/500 - (5%)

  Fly     7 DQRPVKDEPP-QEDTFEEELIFISNSDFEELESEIKI-----------ENFCSYGKDLEPVKGVP 59
            |:.|:.:|.. |:..|.||       .||.:|.:...           |..|.: .|.|......
Mouse   191 DEDPLGEEGVYQKGHFLEE-------PFEYVECQKSFPKGTVFLNHLEEEPCDW-NDAEVAFLQT 247

  Fly    60 SKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTH 124
            |.|...:..:.:.:|       ::|.||.|:|.:|.....|.|.|..|:||:||.|.|||.::..
Mouse   248 SDLSAHQDSLMEMKP-------YECQQCGKSFCKKSKFVIHQRTHTGEKPFKCSQCGKSFCQKGT 305

  Fly   125 YKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHS 188
            ...|...|. ::|::|:.|.|||.|...|.||...|:||:|:||..|..||.:|:||..|.||||
Mouse   306 LTVHQRTHTGEKPYECTECGKTFYQKLHLIQHQRTHSGEKPYKCGYCGKSFCQKTHLTQHQRTHS 370

  Fly   189 EERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQ 252
            .|||:.|..|.|.|...|.|.:|.:.|...:.:|||.|.|.|..:|.|..|:.|| .|:.::|.:
Mouse   371 GERPYVCHDCGKTFSQKSALNDHQKIHTGVKLYKCSECGKCFCRKSTLTTHMRTHTGEKPYECNE 435

  Fly   253 CPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRS 317
            |.|.|.:...|.:|.|.|:||.|::|..|.::|..||.|..|...|.|::|.:|::|...|:..|
Mouse   436 CGKFFSRLSYLTVHYRTHSGEKPYECAECGKSFYLNSALMRHQRVHTGEKPYECNECGKLFSQLS 500

  Fly   318 LYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDH 382
            ...||.|.|:..:.|:|:||.|:|::.|.|..|:::|.||:|::|..|.|.|...::|.:|...|
Mouse   501 YLTVHHRTHSGVKPYECSECGKTFYQNSALCRHRRIHRGEKPYECYICGKFFSQMSYLTIHHRIH 565

  Fly   383 IGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCS 447
            .|||..:|..|.|.|..:|.|..|.:.|||:..:||..|.|.::..|.|.:|.|.|:||.||:|:
Mouse   566 SGEKPYECRECGKSFCQNSALNRHQRTHTGEKAYECYECGKCFSQMSYLTIHHRIHSGEKPFECN 630

  Fly   448 HCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|.|.|:|.:....|.|||:|||||:|:.|..::..||:...|.|
Mouse   631 ECGKAFSRMSYLTVHHRTHSGEKPYECTECGKKFYHKSAFNSHQR 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/405 (40%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp12	NP_001276518.1	KRAB	8..68	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..129
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..198		2/6 (33%)
		COG5048	251..677	CDD:227381	165/431 (38%)
		C2H2 Zn finger	265..285	CDD:275368	8/19 (42%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		C2H2 Zn finger	321..341	CDD:275368	9/19 (47%)
		C2H2 Zn finger	349..369	CDD:275368	9/19 (47%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	601..621	CDD:275368	7/19 (37%)
		C2H2 Zn finger	629..649	CDD:275368	7/19 (37%)
		C2H2 Zn finger	657..677	CDD:275368	5/18 (28%)