DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and Zfp12

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001276518.1	Gene:	Zfp12 / 231866	MGIID:	99157	Length:	686	Species:	Mus musculus

Alignment Length:	500	Identity:	182/500 - (36%)
Similarity:	270/500 - (54%)	Gaps:	29/500 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DQRPVKDEPP-QEDTFEEELIFISNSDFEELESEIKI-----------ENFCSYGKDLEPVKGVP 59
            |:.|:.:|.. |:..|.||       .||.:|.:...           |..|.: .|.|......
Mouse   191 DEDPLGEEGVYQKGHFLEE-------PFEYVECQKSFPKGTVFLNHLEEEPCDW-NDAEVAFLQT 247

  Fly    60 SKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTH 124
            |.|...:..:.:.:|       ::|.||.|:|.:|.....|.|.|..|:||:||.|.|||.::..
Mouse   248 SDLSAHQDSLMEMKP-------YECQQCGKSFCKKSKFVIHQRTHTGEKPFKCSQCGKSFCQKGT 305

  Fly   125 YKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHS 188
            ...|...|. ::|::|:.|.|||.|...|.||...|:||:|:||..|..||.:|:||..|.||||
Mouse   306 LTVHQRTHTGEKPYECTECGKTFYQKLHLIQHQRTHSGEKPYKCGYCGKSFCQKTHLTQHQRTHS 370

  Fly   189 EERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQ 252
            .|||:.|..|.|.|...|.|.:|.:.|...:.:|||.|.|.|..:|.|..|:.|| .|:.::|.:
Mouse   371 GERPYVCHDCGKTFSQKSALNDHQKIHTGVKLYKCSECGKCFCRKSTLTTHMRTHTGEKPYECNE 435

  Fly   253 CPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRS 317
            |.|.|.:...|.:|.|.|:||.|::|..|.::|..||.|..|...|.|::|.:|::|...|:..|
Mouse   436 CGKFFSRLSYLTVHYRTHSGEKPYECAECGKSFYLNSALMRHQRVHTGEKPYECNECGKLFSQLS 500

  Fly   318 LYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDH 382
            ...||.|.|:..:.|:|:||.|:|::.|.|..|:::|.||:|::|..|.|.|...::|.:|...|
Mouse   501 YLTVHHRTHSGVKPYECSECGKTFYQNSALCRHRRIHRGEKPYECYICGKFFSQMSYLTIHHRIH 565

  Fly   383 IGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCS 447
            .|||..:|..|.|.|..:|.|..|.:.|||:..:||..|.|.::..|.|.:|.|.|:||.||:|:
Mouse   566 SGEKPYECRECGKSFCQNSALNRHQRTHTGEKAYECYECGKCFSQMSYLTIHHRIHSGEKPFECN 630

  Fly   448 HCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|.|.|:|.:....|.|||:|||||:|:.|..::..||:...|.|
Mouse   631 ECGKAFSRMSYLTVHHRTHSGEKPYECTECGKKFYHKSAFNSHQR 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/405 (40%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	14/24 (58%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp12	NP_001276518.1	C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	601..621	CDD:275368	7/19 (37%)
		C2H2 Zn finger	629..649	CDD:275368	7/19 (37%)
		C2H2 Zn finger	657..677	CDD:275368	5/18 (28%)
		KRAB	8..68	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..198		2/6 (33%)
		COG5048	251..677	CDD:227381	165/431 (38%)
		C2H2 Zn finger	265..285	CDD:275368	8/19 (42%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		C2H2 Zn finger	321..341	CDD:275368	9/19 (47%)
		C2H2 Zn finger	349..369	CDD:275368	9/19 (47%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900