DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and Zfp97

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_035895.3	Gene:	Zfp97 / 22759	MGIID:	105921	Length:	546	Species:	Mus musculus

Alignment Length:	499	Identity:	167/499 - (33%)
Similarity:	254/499 - (50%)	Gaps:	43/499 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EPPQEDTFEEELIFISNS------DFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKK 72
            :|.|:..:::.::....:      ::||...|...||           .|.|::      .:.:.
Mouse    31 DPSQKSLYKDVMLETYRNLTAIGYNWEEDNIEEDCEN-----------SGRPTR------HLQRD 78

  Fly    73 RPLRKQTDTFKCTQCQKTFTRKE--------------NLESHLRLHAEERPFECSHCSKSFGRRT 123
            .|.......|:|.|....|.|..              :.:.|.|.|.||:.::.:.|.|:|....
Mouse    79 GPSNTGEKPFECIQYDGAFARNHHQLHKDTGSFMSYTDRQIHRRPHTEEKVYDGNQCGKTFSCHN 143

  Fly   124 HYK-RHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTH 187
            |:: |......::|::|:.|.|.|.:||:|..|...||||:|:||.||...|...|.|.:|.|.|
Mouse   144 HFEIRKGTYTGEKPYECNQCGKAFARNSNLLDHKRIHTGEKPYKCKQCGKDFTHHSTLHIHKRIH 208

  Fly   188 SEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCT 251
            :.|:.::|..|    ...:|||.|..||...:..:.:.|.|:|.....||.|..|| .|:.::|.
Mouse   209 TREKTYKCNQC----MTIAHLQCHKITHTGEKLCEYNQCWKAFAYHKTLQIHERTHTGEKLYQCN 269

  Fly   252 QCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMR 316
            ||.|.|..:.:||||.|.|.||.|::|..|.:.||....||.|...|.|::|.:|:||...|...
Mouse   270 QCAKAFPYHRTLQIHERTHTGEKPYECNQCGKAFACLRNLQNHKTTHTGEKPYECNQCGRAFRQY 334

  Fly   317 SLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLD 381
            ...:.|.|:||||:.::|.:|.|:|...|.|..|::.||||:|::|..|.|.|.|..:|::|...
Mouse   335 VYLQCHERIHTREKPFECNQCGKAFAHHSTLQRHKRTHTGEKPYECNQCGKAFACPRYLQIHKRT 399

  Fly   382 HIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKC 446
            |.|||..:|:.|.|.|.......:|.:.|||:..:||..|.|::..:..|.:|.||||||.|::|
Mouse   400 HTGEKPYECNQCGKAFACYQSFQIHKRTHTGEKPYECNQCGKAFACNRYLQIHKRTHTGERPYEC 464

  Fly   447 SHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            :.|.|.|...:..|.|.|||||||||:|:.|...:||...|.||
Mouse   465 NQCGKAFTCRSNLQIHKRTHTGEKPYECNQCGKAFTQFFPLKRH 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	152/419 (36%)
		C2H2 Zn finger	84..104	CDD:275368	6/33 (18%)
		C2H2 Zn finger	112..132	CDD:275368	5/20 (25%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	7/24 (29%)
		C2H2 Zn finger	195..215	CDD:275368	6/19 (32%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	10/19 (53%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
Zfp97	NP_035895.3	KRAB	13..>54	CDD:214630	2/22 (9%)
		KRAB	13..52	CDD:279668	2/20 (10%)
		C2H2 Zn finger	133..152	CDD:275368	5/18 (28%)
		COG5048	156..541	CDD:227381	142/357 (40%)
		C2H2 Zn finger	160..180	CDD:275368	8/19 (42%)
		zf-H2C2_2	172..197	CDD:290200	12/24 (50%)
		C2H2 Zn finger	188..208	CDD:275368	8/19 (42%)
		C2H2 Zn finger	216..232	CDD:275368	6/19 (32%)
		C2H2 Zn finger	241..260	CDD:275368	6/18 (33%)
		C2H2 Zn finger	268..288	CDD:275368	10/19 (53%)
		zf-H2C2_2	281..305	CDD:290200	12/23 (52%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-H2C2_2	308..333	CDD:290200	10/24 (42%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	336..361	CDD:290200	10/24 (42%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		zf-H2C2_2	365..389	CDD:290200	11/23 (48%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		zf-H2C2_2	392..417	CDD:290200	10/24 (42%)
		C2H2 Zn finger	408..428	CDD:275368	5/19 (26%)
		zf-H2C2_2	420..445	CDD:290200	8/24 (33%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		zf-H2C2_2	448..473	CDD:290200	13/24 (54%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		zf-H2C2_2	476..501	CDD:290200	13/24 (54%)
		C2H2 Zn finger	492..512	CDD:275368	7/17 (41%)
		zf-H2C2_2	505..529	CDD:290200	3/4 (75%)
		C2H2 Zn finger	520..540	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900