DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp93

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001347156.1	Gene:	Zfp93 / 22755	MGIID:	107611	Length:	663	Species:	Mus musculus

Alignment Length:	418	Identity:	158/418 - (37%)
Similarity:	224/418 - (53%)	Gaps:	3/418 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 KQTDTFKCTQCQKTFTRKENLESHLR-LHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCS 140
            ::...::|::.|:.|:...:||.|.: |..::.|...:|...........:..:....|| :.|.
Mouse   243 REQKAYQCSRGQEVFSDSPSLELHQQTLLGKKSPVHSTHKDTRHSPSVPIQPSVHPGRKR-YWCH 306

  Fly   141 HCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNN 205
            .|.|.|.|:|:|:.|...||||:|::|..|...|:|.|.|.:|.|.|:.|:|::|..|.|.|...
Mouse   307 ECGKGFRQSSALQTHQRVHTGEKPYRCDSCGKGFSRSSDLNIHRRVHTGEKPYKCEVCGKGFTQW 371

  Fly   206 SHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQCPKTFLQNDSLQIHLRV 269
            :|||.|.|.|...:|:||..|.|.|...|.|..|...|. |:.::|.:|.|.|..:.:|.||.||
Mouse   372 AHLQAHERIHTGEKPYKCGDCGKRFSCSSNLHTHQRVHTEEKPYECNECGKRFSLSGNLDIHQRV 436

  Fly   270 HAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKC 334
            |.||.|:||..|.:.|:..|..|.|...|.|::|..||.|...|:..|.:..|.|:||.|:.|:|
Mouse   437 HTGEKPYKCEECGKGFSSASSFQSHQRVHTGEKPFHCSVCGKNFSRSSHFLDHQRIHTGEKPYRC 501

  Fly   335 AECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKL 399
            ..|.|.|.....|..||.||||::|:||..|.|.|...:.|:.|...|.|||..||:.|.|:|..
Mouse   502 EVCGKRFPWSLSLHSHQSVHTGKKPYKCGECGKGFSHASSLQAHHSVHTGEKPFKCNVCQKQFSK 566

  Fly   400 SSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLR 464
            :|.|..|.:.|||:..::|..|.|:::..|:|.:|.|.||||.||||..|.|.|..|.....|.|
Mouse   567 TSNLQAHQRVHTGEKPYKCDTCGKAFSQKSSLQVHQRIHTGEKPFKCEECGKEFRWSVGLSSHQR 631

  Fly   465 THTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|||||||.|..|...::|.|....|.|
Mouse   632 VHTGEKPYTCQQCGKGFSQASYFHMHQR 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	153/402 (38%)
		C2H2 Zn finger	84..104	CDD:275368	6/20 (30%)
		C2H2 Zn finger	112..132	CDD:275368	1/19 (5%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp93	NP_001347156.1	KRAB	25..66	CDD:307490
		COG5048	275..>613	CDD:227381	130/338 (38%)
		C2H2 Zn finger	305..325	CDD:275368	8/19 (42%)
		C2H2 Zn finger	333..353	CDD:275368	8/19 (42%)
		C2H2 Zn finger	361..381	CDD:275368	9/19 (47%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		C2H2 Zn finger	501..521	CDD:275368	7/19 (37%)
		C2H2 Zn finger	529..549	CDD:275368	6/19 (32%)
		C2H2 Zn finger	557..577	CDD:275368	7/19 (37%)
		C2H2 Zn finger	585..605	CDD:275368	7/19 (37%)
		C2H2 Zn finger	613..633	CDD:275368	7/19 (37%)
		C2H2 Zn finger	641..661	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900