DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp52

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_653098.2	Gene:	Zfp52 / 22710	MGIID:	99199	Length:	724	Species:	Mus musculus

Alignment Length:	463	Identity:	168/463 - (36%)
Similarity:	254/463 - (54%)	Gaps:	24/463 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SKLKTCKSKIAKKRPL-------------------RKQT--DTFKCTQCQKTFTRKENLESHLRL 103
            |.|||.::....|:|.                   |:.|  ..:||.||.::|....:|..|.::
Mouse   227 SSLKTDQTLHTAKKPYKCKEGGKLLVQLSALKSHQRRHTGEKPYKCQQCDRSFAHCASLRWHQKI 291

  Fly   104 HAEERPFECSHCSKSFGRRTHYKRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKC 167
            |:.|..:||..|.||....:|.|||...| .::|::...|..:.|.||:||.|...||.|:|::.
Mouse   292 HSPEIHYECKECGKSCFELSHLKRHCRIHTAEKPYRYEVCDTSITVNSTLKTHHKIHTREKPYRY 356

  Fly   168 TQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSF-K 231
            .:|..|..:.|:|:.:.|.|:.:||:.||.|:|.|..:|:|::|.:.|...:|.||..|.||| :
Mouse   357 RECDKSITKCSYLRTYQRVHTGKRPYRCTECDKFFTKHSNLRQHQKIHTGEKPPKCKDCDKSFLR 421

  Fly   232 LRSILQKHLLTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLL 296
            :.|:..:..:...||.::|.:|.::|....:|::|.|||.||.|::|..|.::|...|.|::|..
Mouse   422 ISSVRIRQKIHAGERRYRCKECGRSFTWFSNLRVHQRVHTGERPYRCKECGKSFTTGSNLRVHQK 486

  Fly   297 EHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFK 361
            .|.|::|.||..|..:|...|..|.|.::||.|:.|||.||:|||.:.|:|.:||::||||:.:|
Mouse   487 IHTGEKPYKCKDCDISFLWISNLRTHQKIHTGEKPYKCQECNKSFTRCSYLRDHQKIHTGEKLYK 551

  Fly   362 CTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYT 426
            |..|...|...:.||.|...|.|||..||..|.|.|...|.|..|.:.|||:..::|..|..|:.
Mouse   552 CKDCDISFMWISSLRRHQKIHTGEKPYKCRGCEKSFTQCSTLRDHQKIHTGEKPYKCKDCGISFL 616

  Fly   427 TSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHL 491
            ..|:|..|.:.||||.|:||..|...|...:..:.|.:.|||||||||..|:..:|:.|.|..|
Mouse   617 WISSLRRHQKIHTGEKPYKCKDCDISFLWISNLRTHQKIHTGEKPYKCQECNKSFTRCSYLRVH- 680

  Fly   492 RRTLCGTK 499
            :||..|.|
Mouse   681 QRTHSGEK 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	154/426 (36%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	8/19 (42%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	5/19 (26%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/20 (30%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	4/19 (21%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
Zfp52	NP_653098.2	KRAB	12..52	CDD:366587
		C2H2 Zn finger	134..153	CDD:275368
		COG5048	184..615	CDD:227381	136/387 (35%)
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	216..264	CDD:275368	7/36 (19%)
		C2H2 Zn finger	244..259	CDD:275368	0/14 (0%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	329..348	CDD:275368	7/18 (39%)
		C2H2 Zn finger	357..376	CDD:275368	5/18 (28%)
		C2H2 Zn finger	384..404	CDD:275368	8/19 (42%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	6/19 (32%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	10/19 (53%)
		C2H2 Zn finger	552..572	CDD:275368	6/19 (32%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..628	CDD:275368	6/19 (32%)
		zf-H2C2_2	620..643	CDD:372612	10/22 (45%)
		C2H2 Zn finger	636..656	CDD:275368	4/19 (21%)
		zf-H2C2_2	648..673	CDD:372612	11/24 (46%)
		C2H2 Zn finger	664..684	CDD:275368	7/20 (35%)
		zf-H2C2_5	690..714	CDD:372805
		C2H2 Zn finger	692..712	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900