DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp28

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_780456.2	Gene:	Zfp28 / 22690	MGIID:	99175	Length:	825	Species:	Mus musculus

Alignment Length:	496	Identity:	172/496 - (34%)
Similarity:	257/496 - (51%)	Gaps:	38/496 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EDTFE--EELIFISNSDFEE--------------LESEIKIENFCSYGKDLEPVKGVPSKLKTCK 66
            |.|||  |:.....|..|.|              |.|..:..:.|..||.......|..:...|.
Mouse   308 ECTFERNEQETVTPNRAFSEGRDGMCIESGRWFHLNSSDERSHNCDSGKSFSSNPVVVKETGICS 372

  Fly    67 SKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLK 131
            .|           ..|:|.:|:||||:..:|..|.|:|..|:|::|:.|.|:|...:.:.||...
Mouse   373 GK-----------KLFQCNECKKTFTQSSSLTVHQRIHTGEKPYKCNQCGKAFSDGSSFARHQRC 426

  Fly   132 HE-KRPHKCSHCSKTFTQNSSLKQH-LHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFE 194
            |. |:|::|..|.|.|.||:||.:| .:.||||:||.|..|..:|:....|..|.|.|:.|:|:.
Mouse   427 HTGKKPYECPECGKAFIQNTSLVRHWRYYHTGEKPFDCIDCGKAFSDHIGLNQHRRIHTGEKPYT 491

  Fly   195 CTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQCPKTFL 258
            |..|.|:|:..|.|..|.|.|...:|::|..|.|:|...:.|.:|...|: |:.|||.:|.|.|.
Mouse   492 CEVCHKSFRYGSSLTVHQRIHTGEKPYECEICRKAFSHHASLTQHQRVHSGEKPFKCKECGKAFR 556

  Fly   259 QNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHV 323
            ||..|..|.|:|.||.||:|..|.::|:.:|:|..|...|.|::|.:|..|...|..::....|.
Mouse   557 QNIHLASHWRIHTGEKPFECGECGKSFSISSQLATHQRIHTGEKPYECKVCRKAFTQKAHLAQHQ 621

  Fly   324 RLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDF----KCRTHLRVHMLDHIG 384
            :.||.|:.|:|.||.|:|.:.:||::||:|||||:|:||..|.|.|    .|..|.|:    |.|
Mouse   622 KTHTGEKPYECKECGKAFSQTTHLIQHQRVHTGEKPYKCLECGKAFGDNSSCTQHRRL----HTG 682

  Fly   385 EKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHC 449
            ::..:|..|.|.||..|.|:.|.:.|||:..:||..|.|:::...:|.:|.|.|:|:.|::|..|
Mouse   683 QRPYECVECGKTFKTKSSLICHRRCHTGEKPYECSACGKAFSHRQSLSVHQRIHSGKKPYECKEC 747

  Fly   450 SKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            .|.|.:.....:|.|.||||:.|........:.|.:....|
Mouse   748 RKTFIQIGHLNQHKRVHTGERTYNYKKGRRAFRQTAHFAHH 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	154/410 (38%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	9/20 (45%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	4/19 (21%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/23 (30%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	2/17 (12%)
Zfp28	NP_780456.2	C2H2 Zn finger	716..736	CDD:275368	6/19 (32%)
		zf-H2C2_2	728..753	CDD:290200	10/24 (42%)
		C2H2 Zn finger	744..764	CDD:275368	6/19 (32%)
		C2H2 Zn finger	772..792	CDD:275368	2/17 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..65
		KRAB	103..163	CDD:214630
		KRAB	103..142	CDD:279668
		KRAB	<243..281	CDD:214630
		COG5048	341..763	CDD:227381	156/436 (36%)
		C2H2 Zn finger	355..371	CDD:275368	3/15 (20%)
		zf-C2H2	377..399	CDD:278523	10/21 (48%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..415	CDD:290200	9/23 (39%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		zf-H2C2_2	419..444	CDD:290200	9/24 (38%)
		C2H2 Zn finger	435..453	CDD:275368	9/17 (53%)
		C2H2 Zn finger	464..484	CDD:275368	6/19 (32%)
		zf-H2C2_2	477..501	CDD:290200	10/23 (43%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		zf-H2C2_2	504..529	CDD:290200	9/24 (38%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		zf-H2C2_2	532..557	CDD:290200	10/24 (42%)
		C2H2 Zn finger	548..568	CDD:275368	9/19 (47%)
		zf-H2C2_2	560..584	CDD:290200	10/23 (43%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)
		zf-H2C2_2	589..613	CDD:290200	8/23 (35%)
		C2H2 Zn finger	604..624	CDD:275368	4/19 (21%)
		zf-H2C2_2	616..641	CDD:290200	10/24 (42%)
		C2H2 Zn finger	632..652	CDD:275368	9/19 (47%)
		zf-H2C2_2	644..667	CDD:290200	14/22 (64%)
		C2H2 Zn finger	660..680	CDD:275368	7/23 (30%)
		C2H2 Zn finger	688..708	CDD:275368	8/19 (42%)
		zf-H2C2_2	700..725	CDD:290200	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900