DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp7

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001345745.1	Gene:	Zfp7 / 223669	MGIID:	99208	Length:	685	Species:	Mus musculus

Alignment Length:	503	Identity:	170/503 - (33%)
Similarity:	237/503 - (47%)	Gaps:	79/503 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLK 131
            ||:.:::.:....:.:.|.:|.|.|..:..|..|...|..|:.::|:.|:|.|...:...||...
Mouse   177 SKLIRRQSVPTGENRYPCEECGKAFRWRSRLNQHKLSHTGEKSYQCNKCTKVFASSSRLIRHQRA 241

  Fly   132 HE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFEC 195
            |. ::|.||..|.|.|...|.|.||...|||||||||.:|...|...:.|..|.|.|:.|:|:.|
Mouse   242 HTGEKPFKCDQCGKRFVLASVLTQHQRIHTGERPFKCAECGKGFHLSAKLVQHQRIHTGEKPYRC 306

  Fly   196 THCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQ 259
            ..|.|.|..:|.|..|.|.|...|||.|..|.|:|..||.|.:|..|| .||.:.|.:|.|.|.|
Mouse   307 EECGKTFGQSSSLVHHQRIHTGERPFICQECGKAFCQRSQLSRHRRTHTGERPYSCQECGKAFCQ 371

  Fly   260 NDSLQIHLR-VHAG-----------------------EDPFKCPHCSETFARNSRLQLHLLEHAG 300
            ..:|..|.: :|..                       |.||||..|.:.|...|||..|.:.|:|
Mouse   372 RATLAQHQKMMHTAEKSQMPRASESPSLIACQGNTTEEKPFKCEQCGKAFRWLSRLNQHQVVHSG 436

  Fly   301 KEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHC 365
            ::|.:|::||..|...|....|.|.||.|:.:||.||.|.|.:.|||::||::||||:|:.|..|
Mouse   437 EKPYQCNKCSKAFGCTSRLIRHQRTHTGEKPFKCDECGKRFVQSSHLIQHQRIHTGEKPYVCDDC 501

  Fly   366 FKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSST 430
            .:.|...:.|..|...|.|||..|||.|.|.|.:|:||..|.:.|||:..:.|..|.|::..:||
Mouse   502 GRAFTQSSSLIYHQRIHKGEKPYKCSQCGKAFSMSTQLTSHQRTHTGERPYTCNECGKTFRQNST 566

  Fly   431 LHMHLRTHTGELPFKCSHCSKLFARSA---EHQE------------------------------- 461
            |..|...|....|::|:.|.|.|:||:   |||.
Mouse   567 LFQHQIIHVRVKPYECNECGKAFSRSSYLIEHQRIHTRAQGGHEFGDTPESPTVLNHKKVHTVKK 631

  Fly   462 -------------------HLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
                               |.|.||||:||||:.|...:.|.:.|.:|
Mouse   632 LYQCDDCDKVFRWRSYLIIHQRIHTGERPYKCNACGKAFHQIAKLTQH 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	164/482 (34%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	7/20 (35%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	11/72 (15%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp7	NP_001345745.1	KRAB	4..65	CDD:214630
		C2H2 Zn finger	194..214	CDD:275368	6/19 (32%)
		C2H2 Zn finger	222..242	CDD:275368	6/19 (32%)
		COG5048	246..668	CDD:227381	150/421 (36%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..380	CDD:275368	7/17 (41%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		C2H2 Zn finger	470..490	CDD:275368	10/19 (53%)
		C2H2 Zn finger	498..518	CDD:275368	5/19 (26%)
		C2H2 Zn finger	526..546	CDD:275368	9/19 (47%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	9/19 (47%)
		C2H2 Zn finger	635..655	CDD:275368	2/19 (11%)
		C2H2 Zn finger	663..683	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000