DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF485

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001305069.1	Gene:	ZNF485 / 220992	HGNCID:	23440	Length:	441	Species:	Homo sapiens

Alignment Length:	357	Identity:	127/357 - (35%)
Similarity:	177/357 - (49%)	Gaps:	55/357 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHC 198
            ::.:||..|.|.|..|||...|...||.|:|.||.:|..:|...|.|..|.:.|:.::|:.|..|
Human   127 EKNYKCKECGKVFKYNSSFISHQRNHTSEKPHKCKECGIAFMNSSSLLNHHKVHAGKQPYRCIEC 191

  Fly   199 EKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERSFKCTQCPKTFLQNDSL 263
            .|..|.:|....|.|.|...:|.||..|.|:|:..|||..
Human   192 GKFLKKHSTFINHQRIHSREKPHKCIECGKTFRKNSILLS------------------------- 231

  Fly   264 QIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTR 328
              |.|:|.|:.|:||..|.:.||:|:.|..|...|:|::|.||::|...|...|....|.::||.
Human   232 --HQRIHTGQKPYKCNDCGKAFAQNAALTRHERIHSGEKPFKCNKCGRAFRDNSTVLEHQKIHTG 294

  Fly   329 ERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYC 393
            |:.|:|.||.|:|.|.|.|:.||::||||:|:   ||.|                         |
Human   295 EKPYQCNECGKAFRKSSTLISHQRMHTGEKPY---HCSK-------------------------C 331

  Fly   394 SKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAE 458
            .|.|:.||....|.:.|:|...::|..|.|::|.||||..|.|.||||.|:.|..|.|.|..|:.
Human   332 GKSFRYSSSFAGHQKTHSGNKPYQCRDCGKAFTKSSTLTGHQRIHTGEKPYHCKKCGKAFRHSSG 396

  Fly   459 HQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            ..||.|.|||||||||:.|...:.:.|:|.:|
Human   397 LVEHQRLHTGEKPYKCNECGKAFPRSSALKQH 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	123/343 (36%)
		C2H2 Zn finger	84..104	CDD:275368
		C2H2 Zn finger	112..132	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	7/24 (29%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	2/19 (11%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	3/19 (16%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	10/19 (53%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF485	NP_001305069.1	KRAB	11..71	CDD:214630
		KRAB	11..50	CDD:279668
		COG5048	<124..361	CDD:227381	93/288 (32%)
		C2H2 Zn finger	132..152	CDD:275368	8/19 (42%)
		C2H2 Zn finger	160..180	CDD:275368	6/19 (32%)
		C2H2 Zn finger	188..208	CDD:275368	7/19 (37%)
		C2H2 Zn finger	216..236	CDD:275368	9/46 (20%)
		zf-H2C2_2	229..253	CDD:290200	10/50 (20%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		zf-H2C2_2	256..279	CDD:290200	8/22 (36%)
		C2H2 Zn finger	272..292	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..307	CDD:290200	9/19 (47%)
		C2H2 Zn finger	300..320	CDD:275368	10/19 (53%)
		zf-H2C2_2	313..337	CDD:290200	14/51 (27%)
		C2H2 Zn finger	328..348	CDD:275368	8/44 (18%)
		C2H2 Zn finger	356..376	CDD:275368	10/19 (53%)
		zf-H2C2_2	372..393	CDD:290200	11/20 (55%)
		C2H2 Zn finger	384..404	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..419	CDD:290200	13/21 (62%)
		C2H2 Zn finger	412..432	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000