DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp354a

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001334424.1	Gene:	Zfp354a / 21408	MGIID:	103172	Length:	573	Species:	Mus musculus

Alignment Length:	566	Identity:	184/566 - (32%)
Similarity:	268/566 - (47%)	Gaps:	107/566 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TFEEELIFISNSDFEE-------LESEIKIENFCSYGKDLEPVKGVP-SKLKTCKS--------K 68
            |||:..:..:..::::       |..|:.:||:    .:|..:.|.| :|.|....        |
Mouse    15 TFEDVAVLFTRDEWKKLVPSQRSLYREVMLENY----SNLASLAGFPFTKPKVISLLQQGEDPWK 75

  Fly    69 IAKKRP------LRKQTDTFKCTQCQKTFTRK----------------ENLESH----------- 100
            :.::.|      |:....|.|.||.|.:..|:                |||..|
Mouse    76 VEEEGPGGFSLGLKCSQRTTKSTQTQDSSFRELIMRKSKRKEPWNMKSENLSIHEGKLEEKWDVN 140

  Fly   101 --------------LRLHAEERPFEC----SHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFT 147
                          .:.|.|:|..||    |:.|...|         :..:|| :|||.|.|||.
Mouse   141 ASTIERSYKSNELSPKSHREKRSSECEKQISYLSNPLG---------ITPDKR-YKCSMCEKTFI 195

  Fly   148 QNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHL 212
            ..|||::|...|:||:.|||.:||.:|::.|.|..|..||:.|:|:.|..|.|||..::.|.:||
Mouse   196 NTSSLRKHEKNHSGEKLFKCKECSKAFSQSSALIQHQITHTGEKPYVCKECGKAFTLSTSLYKHL 260

  Fly   213 RTHQEARPFKCSHCSKSFKLRSILQKHLLTHA--------------------------ERSFKCT 251
            |||...:.::|..|.|||..||.|..|...||                          ::::.|.
Mouse   261 RTHTVEKSYRCKECGKSFGRRSGLFIHQKVHAGENPYKYNPGRKASTSLSGCQRIHSRKKTYLCN 325

  Fly   252 QCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMR 316
            :|..||..:.||:.|.|:|.||.||||..|...|::::.|..|...|.|::|.:||:|...|...
Mouse   326 ECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCSECGKGFTSI 390

  Fly   317 SLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLD 381
            |....|..:||.|:.|.|.||.|:....|.|:.|:::||||:|.||..|.|.|:..:.|..|...
Mouse   391 SRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRM 455

  Fly   382 HIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKC 446
            |.||:..||:.|.|.|:.:|.|..|.:.|||:..:.|..|..|:..||.|..|.|.||||.||||
Mouse   456 HTGERPYKCNECGKTFRCNSSLSNHQRTHTGEKPYRCQECGMSFGQSSALIQHRRIHTGEKPFKC 520

  Fly   447 SHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            :.|.|.|.:|:....|.|.|||||||:|:.|...:..:|||..|.:
Mouse   521 NTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKLFNHRSSLTNHYK 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	166/480 (35%)
		C2H2 Zn finger	84..104	CDD:275368	8/60 (13%)
		C2H2 Zn finger	112..132	CDD:275368	4/23 (17%)
		C2H2 Zn finger	139..159	CDD:275368	10/19 (53%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
Zfp354a	NP_001334424.1	KRAB	14..74	CDD:214630	12/62 (19%)
		SFP1	<128..264	CDD:227516	48/145 (33%)
		C2H2 Zn finger	187..207	CDD:275368	10/19 (53%)
		COG5048	211..568	CDD:227381	135/356 (38%)
		C2H2 Zn finger	215..235	CDD:275368	7/19 (37%)
		C2H2 Zn finger	243..263	CDD:275368	9/19 (47%)
		C2H2 Zn finger	271..291	CDD:275368	9/19 (47%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		C2H2 Zn finger	352..372	CDD:275368	5/19 (26%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000