DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp273

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_938081.2	Gene:	Zfp273 / 212569	MGIID:	3036278	Length:	501	Species:	Mus musculus

Alignment Length:	413	Identity:	167/413 - (40%)
Similarity:	225/413 - (54%)	Gaps:	4/413 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTF 146
            ||.:|.|.|.|...|..|.|:|..|||::|..|.|||...:..|:|...|. ::|:||..|.|.|
Mouse    82 KCKECGKAFDRNSVLIQHQRIHTGERPYKCEECGKSFNYSSSLKQHQRIHTGEKPYKCEVCGKAF 146

  Fly   147 TQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEH 211
            ..:|.|.:|...||||:.::|.:|...|...|.|.||.|.|:.|:|::|..|.|||...:.|.:|
Mouse   147 NCSSYLGKHQRIHTGEKRYRCEECGKPFTNCSGLIVHRRVHTGEKPYKCEECGKAFSVRTTLSKH 211

  Fly   212 LRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDP 275
            .|.|...:|:||..|.|:|.:.|.|.||...| .|:.:||.:|...|.....|..|.|.|.||.|
Mouse   212 QRIHTGEKPYKCDECGKTFNVHSTLSKHQRIHTGEKPYKCEECGMAFNVRCILSKHQRTHTGEKP 276

  Fly   276 FKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKS 340
            :||..|.:.|..:|.|..|...|.|::..||..|...|:..|....|.|:||..:.|||.||.|:
Mouse   277 YKCKECGKAFNCSSSLHQHQQIHRGEKLYKCDDCGQAFSCSSYLYKHRRIHTGMKPYKCKECGKA 341

  Fly   341 FFKKSHLVEHQQVHTGERPFKCTHCFKDFK-CRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLL 404
            |:...:|:.||::||||:|:||..|.|.|. |.|.|: |...|.|||..||..|.|.|.....|:
Mouse   342 FYCSVNLIYHQRIHTGEKPYKCNECGKAFSICSTFLK-HQRIHSGEKPYKCKECEKAFNNCYNLI 405

  Fly   405 VHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGE 469
            .|.:.|||:..::|..|.|::..:|:|..|.|.||||.|:||..|.|.|..|:..:.|.|.||||
Mouse   406 QHQRIHTGEKPYKCKDCGKAFNYTSSLAQHERIHTGEKPYKCEECGKAFNSSSNLKHHWRLHTGE 470

  Fly   470 KPYKCSHCSTRYTQKSSLGRHLR 492
            |||||..|...:...|...||.|
Mouse   471 KPYKCEQCGKAFKNCSGFTRHYR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	162/397 (41%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	8/20 (40%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp273	NP_938081.2	KRAB	5..65	CDD:214630
		KRAB	5..44	CDD:279668
		COG5048	79..463	CDD:227381	151/381 (40%)
		C2H2 Zn finger	83..103	CDD:275368	8/19 (42%)
		zf-H2C2_2	96..120	CDD:290200	12/23 (52%)
		C2H2 Zn finger	111..131	CDD:275368	7/19 (37%)
		zf-H2C2_2	123..148	CDD:290200	9/24 (38%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	180..203	CDD:290200	11/22 (50%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		zf-H2C2_2	208..231	CDD:290200	9/22 (41%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		zf-H2C2_2	236..259	CDD:290200	8/22 (36%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		zf-H2C2_2	264..288	CDD:290200	11/23 (48%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		zf-H2C2_2	319..342	CDD:290200	10/22 (45%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		zf-H2C2_2	347..371	CDD:290200	12/23 (52%)
		C2H2 Zn finger	363..383	CDD:275368	8/20 (40%)
		zf-H2C2_2	378..400	CDD:290200	10/22 (45%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..428	CDD:290200	8/24 (33%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		zf-H2C2_2	431..456	CDD:290200	13/24 (54%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900