DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp180

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001038951.1	Gene:	Zfp180 / 210135	MGIID:	1923701	Length:	655	Species:	Mus musculus

Alignment Length:	493	Identity:	167/493 - (33%)
Similarity:	241/493 - (48%)	Gaps:	106/493 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 FISNSDFE---ELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFK----- 83
            |:|:...|   ||...::...           :|.|..|.       :|.||..:|..||
Mouse   229 FVSSPQGEEAYELNGHVQASG-----------RGAPRNLN-------EKVPLEGKTFGFKGRGQV 275

  Fly    84 -----CTQCQKTFTRKE-----------NLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKH 132
                 ....|:....||           :|...||.::||:.|||.:|.|||.    :..||:.|
Mouse   276 LNHSVVLGGQQELLVKEGQDKCKTAPSPSLPQSLRNYSEEKRFECKYCGKSFS----WSSHLIAH 336

  Fly   133 EK-----RPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERP 192
            ::     :|:||:.|.|.||::|.:..|...||||:|::|..|..||.::..|.||.|||:.|||
Mouse   337 QRTHTGEKPYKCNLCGKFFTRSSHVVSHQRIHTGEKPYRCNLCGKSFTQRYVLVVHQRTHTGERP 401

  Fly   193 FECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERSFKCTQCPKTF 257
            :|||.|.|:|:.:..|..|.|||.                           .|:.::||||.|:|
Mouse   402 YECTQCGKSFRQSYKLIAHQRTHT---------------------------GEKPYECTQCGKSF 439

  Fly   258 LQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVH 322
            :|:..|..|.::|:||.|::|.||.::|:::.:|..|...|.|::|.:|:.|..:|:..|....|
Mouse   440 IQSYKLIAHQKIHSGEKPYECSHCGKSFSQSYKLVAHQRTHTGEKPFECNHCGKSFSWSSQLVSH 504

  Fly   323 VRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKV 387
            .|.||.|:.|:|.||.|||.:.||||.||:.||||:|:
Mouse   505 QRTHTGEKPYECNECGKSFNRSSHLVMHQRTHTGEKPY--------------------------- 542

  Fly   388 PKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKL 452
             :|..|.|.|..|..|:||.:.|||:..:||..|.|::..||....|.||||||.|::|:.|.|.
Mouse   543 -QCKQCGKSFSQSYVLVVHQRTHTGEKPYECGQCGKTFRQSSCFTQHQRTHTGEKPYECNQCGKT 606

  Fly   453 FARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            |:.||....|.|||||||||||..|...:...|...||
Mouse   607 FSLSARLIVHQRTHTGEKPYKCGQCGKAFISSSKRSRH 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	154/429 (36%)
		C2H2 Zn finger	84..104	CDD:275368	6/30 (20%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	15/24 (63%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	0/19 (0%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	12/19 (63%)
		C2H2 Zn finger	362..382	CDD:275368	0/19 (0%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp180	NP_001038951.1	COG5048	297..650	CDD:227381	150/407 (37%)
		zf-C2H2	318..340	CDD:278523	10/25 (40%)
		C2H2 Zn finger	320..340	CDD:275368	8/23 (35%)
		zf-H2C2_2	332..357	CDD:290200	9/24 (38%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		zf-H2C2_2	360..385	CDD:290200	10/24 (42%)
		C2H2 Zn finger	376..396	CDD:275368	8/19 (42%)
		zf-H2C2_2	389..413	CDD:290200	15/23 (65%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		zf-H2C2_2	420..441	CDD:290200	11/47 (23%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
		zf-H2C2_2	448..469	CDD:290200	9/20 (45%)
		C2H2 Zn finger	460..480	CDD:275368	6/19 (32%)
		zf-H2C2_2	473..496	CDD:290200	7/22 (32%)
		C2H2 Zn finger	488..508	CDD:275368	6/19 (32%)
		zf-H2C2_2	501..525	CDD:290200	12/23 (52%)
		C2H2 Zn finger	516..536	CDD:275368	12/19 (63%)
		zf-H2C2_2	528..553	CDD:290200	14/52 (27%)
		C2H2 Zn finger	544..564	CDD:275368	8/19 (42%)
		zf-H2C2_2	557..581	CDD:290200	10/23 (43%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	587..608	CDD:290200	11/20 (55%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	613..637	CDD:290200	13/23 (57%)
		C2H2 Zn finger	628..648	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000