DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp719

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001344698.1	Gene:	Zfp719 / 210105	MGIID:	2444708	Length:	735	Species:	Mus musculus

Alignment Length:	435	Identity:	172/435 - (39%)
Similarity:	244/435 - (56%)	Gaps:	4/435 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 KLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHY 125
            |:.|.::...:::.......:|.|..|.|||..|..|.||.....||.|:||..|:||....|..
Mouse   264 KVFTGETAFCQQQITNSMETSFICHTCGKTFLHKSKLTSHSETPREETPYECPDCAKSLRGTTSL 328

  Fly   126 K--RHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHS 188
            :  |.:...|| |::|..|.|:|:..|.||.||..||||:|:.|:.|..:|::||.|.:|.|.|:
Mouse   329 QVLRGVQTKEK-PYECHVCGKSFSYTSHLKVHLRTHTGEKPYACSDCGKAFSQKSVLTIHQRIHT 392

  Fly   189 EERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRS-ILQKHLLTHAERSFKCTQ 252
            .|:|:.|:.|.|.|...|.|.:|.|.|...:|::|..|.|||.::| :|..|.:..:|..:||..
Mouse   393 GEKPYTCSDCGKMFVCASDLTKHCRFHTGEKPYECPDCGKSFSIKSNLLAHHRIHTSEGPYKCFH 457

  Fly   253 CPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRS 317
            |.::|.:...|::|.::|.....|.|..|...|::.|.|..|...|:|::...||.|...|...|
Mouse   458 CGESFRKISQLKVHHQIHTDRRSFVCSDCGMAFSQKSVLTTHQRIHSGEKCYPCSDCGKLFLYAS 522

  Fly   318 LYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDH 382
            ..:.|.|.||.|:.|||.:|.||:..||||..|.::||||||:||..|.|.|:..:||::|...|
Mouse   523 DLKKHCRFHTGEKPYKCHDCGKSYSVKSHLHVHHRIHTGERPYKCDDCGKSFRRNSHLQMHQQTH 587

  Fly   383 IGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCS 447
            .|||..|||.|.|.|:.:|.|.||.:.|||:..|.|..|.|::...|.|..|.|.||||.|:.||
Mouse   588 TGEKPYKCSDCGKSFRRASHLKVHHRIHTGEKPFVCSECGKAFNDRSVLSTHQRIHTGEKPYICS 652

  Fly   448 HCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|.|..:..|..:||.|.|||||||.|:.|...::.|||..||.:
Mouse   653 DCGKAMSSKANLKEHQRIHTGEKPYVCAECGKAFSDKSSFYRHCK 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	164/406 (40%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	6/21 (29%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/20 (40%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
Zfp719	NP_001344698.1	KRAB	48..89	CDD:396083
		C2H2 Zn finger	287..307	CDD:275368	9/19 (47%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		COG5048	335..708	CDD:227381	150/364 (41%)
		C2H2 Zn finger	343..363	CDD:275368	9/19 (47%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		C2H2 Zn finger	399..419	CDD:275368	8/19 (42%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		C2H2 Zn finger	455..475	CDD:275368	5/19 (26%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	9/19 (47%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		C2H2 Zn finger	595..615	CDD:275368	9/19 (47%)
		C2H2 Zn finger	623..643	CDD:275368	7/19 (37%)
		C2H2 Zn finger	651..671	CDD:275368	8/19 (42%)
		C2H2 Zn finger	679..699	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900