DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp184

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_898835.1	Gene:	Zfp184 / 193452	MGIID:	1922244	Length:	737	Species:	Mus musculus

Alignment Length:	487	Identity:	175/487 - (35%)
Similarity:	254/487 - (52%)	Gaps:	46/487 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PVKGVPSKLKTCKSKIAKK---------RPLRKQT--DTFKCTQCQKTFTRKENLESHLRLHAEE 107
            |||    |.|.||.....|         |..|..|  ..:||.:|.|.|:|.|||.:|.|:|..:
Mouse   194 PVK----KEKLCKCNECGKAFTYCSALIRHQRTHTGEKPYKCNECNKAFSRSENLINHQRIHTGD 254

  Fly   108 RPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCS 171
            :|::|..|.|.|.......:|...|. ::|:||..|.|.|:|.:.|.||...||||:|:.||:|.
Mouse   255 KPYKCDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCTECG 319

  Fly   172 TSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSIL 236
            .||:::.|...|.:.|:.|:||:|..|||.|..::||.:|.:.|...:.:||:.|.|:|...|..
Mouse   320 KSFSQRGHFMEHQKIHTGEKPFKCEECEKTFTRSTHLTQHQKIHTGEKTYKCNECGKAFNGPSTF 384

  Fly   237 QKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAG 300
            .:|.:.| .|:.::|.:|.|.|.|:.:|..|.:.|.||.|:.|..|.:.|:..|.|..||..|.|
Mouse   385 IRHHMIHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAECGKAFSYWSSLAQHLKIHTG 449

  Fly   301 KEPLKCSQCSATFAMRSLYRVHVRLHTR----------------------------ERQYKCAEC 337
            ::|.|||.|...|:..|....|.|:|||                            |:.|:|.||
Mouse   450 EKPYKCSDCGKAFSYCSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKEC 514

  Fly   338 SKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQ 402
            .|:|.:.|.|.:|:::||||:|::|..|.|.|...:.|..|...|.||:..||:.|.:.|.....
Mouse   515 GKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSLIQHKKIHTGERPYKCNECGRAFNQKIH 579

  Fly   403 LLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHT 467
            |..|.:.|||...:.||.|.|::...|:|..|.:|||.|.|::|:.|.|.|::::...:|.|.||
Mouse   580 LTQHKRIHTGAKPYACPKCGKTFRHCSSLAQHQKTHTEEKPYQCNKCEKTFSQNSRLTQHQRIHT 644

  Fly   468 GEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTK 499
            ||||||||.|...:|....|..| |.|..|.|
Mouse   645 GEKPYKCSECDKCFTGSVHLTEH-RSTHTGEK 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	158/435 (36%)
		C2H2 Zn finger	84..104	CDD:275368	10/19 (53%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
Zfp184	NP_898835.1	KRAB	28..88	CDD:214630
		COG5048	163..634	CDD:227381	155/443 (35%)
		C2H2 Zn finger	203..223	CDD:275368	3/19 (16%)
		C2H2 Zn finger	231..251	CDD:275368	10/19 (53%)
		C2H2 Zn finger	259..279	CDD:275368	5/19 (26%)
		C2H2 Zn finger	287..307	CDD:275368	8/19 (42%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		C2H2 Zn finger	343..363	CDD:275368	8/19 (42%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275368	0/19 (0%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		C2H2 Zn finger	567..587	CDD:275368	5/19 (26%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		zf-H2C2_2	635..659	CDD:372612	13/23 (57%)
		C2H2 Zn finger	651..671	CDD:275368	7/20 (35%)
		C2H2 Zn finger	679..698	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900