DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF675

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_612203.2	Gene:	ZNF675 / 171392	HGNCID:	30768	Length:	568	Species:	Homo sapiens

Alignment Length:	493	Identity:	175/493 - (35%)
Similarity:	261/493 - (52%)	Gaps:	11/493 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VDQRPVKDEPP-QEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKI 69
            |.:..:.:||| ....|.:|  |....:.::...::.:..:...|.|...:||..| :..||...
Human    65 VKRHEMVNEPPVMCSHFAQE--FWPEQNIKDSFEKVTLRRYEKCGNDNFQLKGCKS-VDECKLHK 126

  Fly    70 AKKRPLRK-----QTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHL 129
            .....|.:     |:..|:|.:..|.|.:..:.:.|...|.|.:||:|..|.:||...:|..||.
Human   127 GGYNGLNQCLPTMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRSFCMLSHLTRHE 191

  Fly   130 LKHEKRPH-KCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPF 193
            ..:.|... ||..|.|...|:|.|.:|...:|.|:.:||.:|..:|.:.|:|..:.:.::.|:|:
Human   192 RNYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNLTEYKKDYAREKPY 256

  Fly   194 ECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTF 257
            :|..|.|||..:|||..|...|...:|:||..|.|:|...|.|..|...| .|:.:.|.:|.|.|
Human   257 KCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLTTHKKIHTGEQPYICEECGKAF 321

  Fly   258 LQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVH 322
            .|:.:|..|.|:|.||.|:||..|.:.|.|:|:|..|...|.|::|.||.:|...|...|....|
Human   322 TQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRSSNLTEH 386

  Fly   323 VRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKV 387
            .::||.|:.|||.||.|:|...|.|..|:::||||:|:||..|.|.|...:.|..|...|.|:|.
Human   387 RKIHTEEKPYKCKECGKAFKHSSALTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKKLHTGKKP 451

  Fly   388 PKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKL 452
            .||..|.|.|..||:|..|.:.|:|:..::|..|.|::..||:|..|.|.||||.|:||..|.|.
Human   452 YKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSSSLTTHKRIHTGEKPYKCEECGKA 516

  Fly   453 FARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            |:||::..||...|||||||||..|...:.|.::|.:|
Human   517 FSRSSKLTEHKIIHTGEKPYKCERCDKAFNQSANLTKH 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	157/410 (38%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	5/19 (26%)
		zf-H2C2_2	179..204	CDD:290200	8/24 (33%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF675	NP_612203.2	KRAB	4..62	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	169..556	CDD:227381	152/386 (39%)
		C2H2 Zn finger	174..194	CDD:275370	7/19 (37%)
		C2H2 Zn finger	202..222	CDD:275368	7/19 (37%)
		C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	258..278	CDD:275368	9/19 (47%)
		zf-H2C2_2	270..295	CDD:290200	10/24 (42%)
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	8/19 (42%)
		zf-H2C2_2	327..351	CDD:290200	11/23 (48%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		zf-H2C2_2	382..407	CDD:290200	11/24 (46%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		zf-H2C2_2	410..435	CDD:290200	12/24 (50%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	8/19 (42%)
		C2H2 Zn finger	482..502	CDD:275368	8/19 (42%)
		zf-H2C2_2	494..519	CDD:290200	13/24 (54%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	538..558	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900