DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF431

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_011526052.1	Gene:	ZNF431 / 170959	HGNCID:	20809	Length:	593	Species:	Homo sapiens

Alignment Length:	533	Identity:	180/533 - (33%)
Similarity:	252/533 - (47%)	Gaps:	81/533 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EPP-----QED-TFEEELIFISNSDFE-------ELESEIKIENFCSYGKDLEPVKGVPSKLKTC 65
            :||     ||. ||.:..|..|..::|       .|...:.:||:    |:|..:.||
Human    40 QPPELLGLQETLTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENY----KNLVFLAGV------- 93

  Fly    66 KSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKS------------ 118
              .::|:.|:       .|.:.:|   ...|::.|..:  :|.|..||:.:|.
Human    94 --AVSKQDPV-------TCLEQEK---EPWNMKRHEMV--DEPPAMCSYFTKDLWPEQDIKDSFQ 144

  Fly   119 ------FGRRTHYKRHLLK-----HEKRPHK-------------------CSHCSKTFTQNSSLK 153
                  :|:..|....|.|     .|.:.||                   |....|.|.:..:..
Human   145 QVILRRYGKCEHENLQLRKGSASVDEYKVHKEGYNELNQCLTTTQSKIFPCDKYVKVFHKFLNAN 209

  Fly   154 QHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEA 218
            :|...|||::||||.:|..||....||..|.|.|..|..::|..|.||||..|.|..|.|.|...
Human   210 RHKTRHTGKKPFKCKKCGKSFCMLLHLSQHKRIHIRENSYQCEECGKAFKWFSTLTRHKRIHTGE 274

  Fly   219 RPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCS 282
            :||||..|.|:||..|.|..|.:.| .|:.::|.:|.|.|.::..|..|..:|.||.|:||..|.
Human   275 KPFKCEECGKAFKQSSTLTTHKIIHTGEKPYRCEECGKAFNRSSHLTTHKIIHTGEKPYKCEECG 339

  Fly   283 ETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHL 347
            :.|.::|.|..|...|||::|.||.:|...|...|....|..:||.|:.|||.||.|.|...|.|
Human   340 KAFNQSSTLSTHKFIHAGEKPYKCEECDKAFNRFSYLTKHKIIHTGEKSYKCEECGKGFNWSSTL 404

  Fly   348 VEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTG 412
            .:|:::||||:|:||..|.|.|...::|..|.:.|.|||..||..|.|.|..|.||..|...|||
Human   405 TKHKRIHTGEKPYKCEVCGKAFNESSNLTTHKMIHTGEKPYKCEECGKAFNRSPQLTAHKIIHTG 469

  Fly   413 KNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHC 477
            :..::|..|.|:::.||.|..|.|.||||.|:||..|.|.|.||:...:|...|||||.|||..|
Human   470 EKPYKCEECGKAFSQSSILTTHKRIHTGEKPYKCEECGKAFNRSSNLTKHKIIHTGEKSYKCEEC 534

  Fly   478 STRYTQKSSLGRH 490
            ...:.|.|:|.:|
Human   535 GKAFNQSSTLTKH 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	158/446 (35%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	7/42 (17%)
		C2H2 Zn finger	139..159	CDD:275368	4/19 (21%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF431	XP_011526052.1	KRAB	51..112	CDD:214630	16/83 (19%)
		KRAB	51..90	CDD:279668	10/42 (24%)
		zf-H2C2_2	209..230	CDD:290200	9/20 (45%)
		COG5048	218..570	CDD:227381	139/330 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	10/19 (53%)
		zf-H2C2_2	264..288	CDD:290200	11/23 (48%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		zf-H2C2_2	292..316	CDD:290200	8/23 (35%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		zf-H2C2_2	319..344	CDD:290200	10/24 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..399	CDD:290200	10/23 (43%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		zf-H2C2_2	404..427	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		zf-H2C2_2	431..456	CDD:290200	11/24 (46%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		zf-H2C2_2	460..484	CDD:290200	8/23 (35%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	488..512	CDD:290200	13/23 (57%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		zf-H2C2_2	515..540	CDD:290200	10/24 (42%)
		C2H2 Zn finger	531..551	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900